PSA Bounce After Radiation Therapy

[kainasar]

I am trying to understand PSA bounce or change in PSA levels after RT and have found two studies useful.

ncbi.nlm.nih.gov/pmc/articl...

nature.com/articles/s41391-...

Some analysts distinguish between PSA bounce and biological recurrence, and see a possibility of an immune response related variance.

[anyone know how to get the program to change links from text to hyperlink? ]

[Tall_Allen]

This may help:

prostatecancer.news/2018/03...

[kainasar in reply to Tall_Allen]

Thanks. Very helpful information. Curious how does one distinguish between the bounce, and biological rec, or missed cancer that needs to be zapped?

[Tall_Allen in reply to kainasar]

One does not even suspect a recurrence until PSA goes up to nadir+2.

[kainasar in reply to Tall_Allen]

Thank you. Need to research that. I wonder if slope says anything.

[Tall_Allen in reply to kainasar]

No. Prostatitis causes rapid increases in PSA.

[kainasar in reply to Tall_Allen]

Interesting. Thanks!

[kainasar]

Update (if you hv a minute) PSA jumped again w slope .8 a mo. MO sent me to PSMA scan. Looks like Im headed toward AART. Thanks.

[kainasar]

PSMA showed new lymph node uptake in region previously radiated, and another directly across, near the other leg.

[Xavier10 in reply to kainasar]

what was the SUV level of the uptake?

[kainasar]

Thanks but dont know the lingo. SUV?

[Xavier10 in reply to kainasar]

I think it's usually called SUV-max and can be about any number but lower numbers can be something else sometimes whereas "avid" numbers (an MO told me 12 is he would say definitely, but can be less also). So your report should have those numbers. Also, will they be biopsying this? I have a PSMA coming up myself, so naturally I'm interested.

[kainasar]

The uptake is shown in colors on the photos from the PSMA. The interpretation analysis report that came with it had some numbers.

MO just put me on an ARAT, along with lupron. and left it at that.