PSA Bounce After Radiation Therapy

[kainasar]

I am trying to understand PSA bounce or change in PSA levels after RT and have found two studies useful.

ncbi.nlm.nih.gov/pmc/articl...

nature.com/articles/s41391-...

Some analysts distinguish between PSA bounce and biological recurrence, and see a possibility of an immune response related variance.

[anyone know how to get the program to change links from text to hyperlink? ]

[Tall_Allen]

This may help:

prostatecancer.news/2018/03...

[kainasar in reply to Tall_Allen]

Thanks. Very helpful information. Curious how does one distinguish between the bounce, and biological rec, or missed cancer that needs to be zapped?

[Tall_Allen in reply to kainasar]

One does not even suspect a recurrence until PSA goes up to nadir+2.

[kainasar in reply to Tall_Allen]

Thank you. Need to research that. I wonder if slope says anything.

[Tall_Allen in reply to kainasar]

No. Prostatitis causes rapid increases in PSA.

[kainasar in reply to Tall_Allen]

Interesting. Thanks!

[kainasar]

Update (if you hv a minute) PSA jumped again w slope .8 a mo. MO sent me to PSMA scan. Looks like Im headed toward AART. Thanks.

[kainasar]

PSMA showed new lymph node uptake in region previously radiated, and another directly across, near the other leg.