Embryo glue thoughts?

[Hope76]

So had my appt today to discuss my upcoming protocol.

On an ultra short protocol starting with Norethisterone 30/06. Baseline scan 15/07 and start Buserelin for 3 days plus Gonal F for FSH injections.

So hoping now am back on gonal f after a failed cycle 3 months ago with Menopur this is going to give me better response than last time. My consultant is not as hopeful though and feels both FSH drugs do pretty much the same and as am 43 this is now age factor. However last year got pregnant (miscarried 7 weeks) am just so sure I was a poor responder to Menopur but only time will tell....

Anyway today I wanted to know if anything else I can take to help (already taking 200mg ubiquinol daily plus vitamin d/folic acid) I asked about baby aspirin as seen it on here so many times. Was told that would only be prescribed If I had blood clotting which I don’t. They say if I took that and don’t need it can have a detrimental effect. They feel same about DHEA and I took it last time but not risking it this time in case it added to the results of only 2 responding follicles.

The Nurse today was surprised I have never been offered IUI as usually offered to poor responders.... feel they should’ve offered it that last time and another thing just found out about despite being patient there for 5 years.

I also asked about embryo glue as despite asking previously was always told didn’t need it and case studies show makes no difference. However 2 patients I know at the clinic recently had successful frozen transfers with the glue. I have had 2 failed FETs ....so felt quite annoyed they always put me off it saying lots of risks for eg ‘embryo disintigrating’ in the glue. However Nurse I seen today was very pro - embryo glue and said if I want it can have it. Really feel it depends who you speak to....wish pushed for it for my second FET.

Anyone got any advise regarding the glue any success or unsuccessful stories to help me decide ?

Thanks, so glad for this forum x

[Drives]

My friend (an embryologist) gave me this advice when I asked her if we should use glue:

"We use it routinely for all our transfers. There’s no strong evidence it improves rates but might benefit certain patients. It’s just a slightly more viscous solution that the embryos are put in to transfer. Haven’t heard of any negative effects & vitrolife the company who make are excellent with their research & development. A lot of private companies do charge quite a bit to use it but I think it’s worth it. It won’t harm your chances. Hope that helps."

We used it and got our BFP 😍

[Hope76 in reply to Drives]

Thank you, that is a great help. Makes me so annoyed that been told in past don’t need it despite a failed FET then another. Just feel if it will help why not have it. It’s £200 at my clinic which is nothing compared to the rest of the bill 🙈

Congratulations on getting your BFP. Best feeling in the world. 😀

[Drives in reply to Hope76]

Aww thank you 😊😊

We thought the same...what's a couple of hundred pound compared to the cost of everything else 😂

Good luck with your next cycle 🍀🤞x x

[Hope76 in reply to Drives]

Exactly, trust me I will be insisting on it this time.

Thanks so much x

[Drives in reply to Hope76]

No worries 😘 all the best x x

[Olivia1980xxx]

Hi hun that great to hear they changing your meds .

My second cycle I had we use embryo glue ...I have 25 months old baby girl.

With my last 3rd cycle we use glue as well ....but this time didn’t work .

Just go with your intuition...do what will make u feel better ...

Even though my last cycle didn’t work I didn’t left my self with questions “what if”....or “maybe we should and why we didn’t “...

I have my appointment on Wednesday coming to discuss with doctor what FET is best for me so we can start in July.

Knowing me I will go again for glue .

Keep us updating hun xx

[Hope76 in reply to Olivia1980xxx]

Hi thanks Olivia that’s really helpful.

Think am just pissed that I did ask for in past and was always basically told not necessary. Given fact I know financially and emotionally this could be last go obviously feel if there is something that can maybe help well hell yeah I want it 😀.

I get what you are saying though no guarantees it is a bloody lottery this IVF. We hit jackpot first time (no glue but double transfer and one stuck). I just need that jackpot one more time please 🙏🏻🤞🏼

Wishing you all the luck in the world with your FET 🍀

[Dotty224]

I used the glue on my second cycle as it was included in the package we paid for. I now 13 weeks pregnant but we did use a different clinic and different protocol so not sure what factor helped us this time. We were told there was no evidence either way if it did help or not. We also used time lapse which I would recommend as they monitor your embryos 24/7 so they pick they best one to transfer. We weren’t offered this on our first cycle so not sure if they transferred poor embryos.

Good luck with your cycle xx

[savido1]

Hi hope76

Thank you for sharing your story. I will probably say rather than focusing on whether you need embryo blue I would invest your money in testing any of your embryos to see if they are normal or abnormal. Majority of embryos that have a high grading are still abnormal. It’s such a shame because mentally think if your embryo is of a higher grade that it’s a better quality but that unfortunately is not true. Our first frozen embryo transfer was unsuccessful even though we had Transferred 2 emb. We decided to get the remaining 6 emb tested for abnormalities (btw all were top grade embs ) and only 1 came back normal!!!!!!. Now I’m in a situation that this has a better chance of working but it’s also my last chance .