From the beginning of the difficulties I had after thyroidectomy, I told myself that if I ever found out the cause of the problem, I would share it with everyone. Now, after 8 months of extensive research, I have come to the following results, which I think are the most complete for those of us who had thyroidectomy:
I assume that you have reached the appropriate dose of Levo and Liothyronine for yourself.
We have three deiodinase enzymes:
D1, which supplies T3 to the blood
D2, which supplies T3 to the cells
D3, which produces reverse T3
By taking T3, we only support D1, but by taking Levo, we get the raw material for the three enzymes
With the above conditions, our entire focus should be on D2 and D3, as follows:
1. Inhibit D3 by consuming antioxidants such as omega-3, vitamin C, and selenium
2. Strengthening D2 with substances such as selenium, zinc, magnesium, iron and ferritin, vitamin A and vitamin D
I have a number of things that the kidneys, such as lack of hunger, lack of stress, light activity, etc.
I hope this post will help all people like me who were once hopeless and came back to life with the help of this site.
Thanks
Written by
amin1376
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Yes, I can say that since I started T3, I feel much better, but I am still a long way from where I was before, when I realized through research that I needed to work on D2 and D3 enzymes
But I can say that thanks to you, my dear friends, the dark path ahead of me has become completely clear
The only thing I need to add to the above is that high doses of T4 completely disrupt the function of the two enzymes D1 and D2, just when my doctor was only increasing my levothyroxine every time
Just out of curiosity: how will you know that your work on D2 and D3 enzymes is successful? I know of no method to measure T3 in cells. Is this really something we can affect ourselves? My impression is the three Ds were introduced by Tania Smith, the Canadian thyroid patient advocate, and before that rT3 was the problem. I could be wrong, of course, but I have been reading about thyroid disease for the past 25 years and D1-D3 seem to be pretty recent concepts. My impression is Tania introduced them, and then others started quoting her (like Paul Robinson).
tania smith quotes (and usually explains quite well) facts taken from multiple sources of scientific research on deiodinases, and she always includes the references.
research on deiodinases has been around since at least the 1980/90's ~ see the list of reference papers used for this paper : academic.oup.com/endo/artic... Deiodinases: How Nonmammalian Research Helped Shape Our Present View
Veerle M Darras , Endocrinology, Volume 162, Issue 6, June 2021
I must confess I’m extremely confused by this post, too. If I’ve understood anything I think that you’re saying that your difficulties since your thyroidectomy are due to poor conversion. That bit I get. That is a common problem.
But then you seem to go on to say that the cause of your poor conversion is some sort of problem with the deiodinase. And there you totally lose me…
We have three deiodinase enzymes:
D1, which supplies T3 to the blood
D2, which supplies T3 to the cells
Well, I wouldn’t exactly call it ‘supplying’. It converts T4 to T3 by removing on atom of iodine. The resulting T3 goes into the blood. OK.
D3, which produces reverse T3
By removing a different atom of iodine. OK.
By taking T3, we only support D1, but by taking Levo, we get the raw material for the three enzymes
But what on earth do you mean ‘supporting’ D1? How does taking any form of thyroid hormone replacement ‘support’ the deiodinase? And how does taking levo give you the raw materials for them? That doesn’t make any sense.
With the above conditions, our entire focus should be on D2 and D3, as follows:
1. Inhibit D3 by consuming antioxidants such as omega-3, vitamin C, and selenium
But why on earth would you want to inhibit D3? It has an important role to play in the scheme of things. If your FT4, for whatever reason, goes too high, D3 will convert most of it to rT3 to stop you ‘going hyper’. That is a built-in safety valve which is very necessary for you well-being.
2. Strengthening D2 with substances such as selenium, zinc, magnesium, iron and ferritin, vitamin A and vitamin D
One would take those, if necessary, anyway. But one has to be very careful not to over-dose on vit A. It can be toxic.
I have a number of things that the kidneys, such as lack of hunger, lack of stress, light activity, etc.
I think there’s something missing from that sentence, it doesn’t make sense.
I hope this post will help all people like me who were once hopeless and came back to life with the help of this site.
Well, it might if you gave a little more explanation about what you think deiodinase are and what they do. As it is, this is all too vague, and I suspect incorrect. We need more information.
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Is it OK to take B vitamins and D3 at same time?
Size of Thyroid and T3 Levels
Six months after Thyroidectomy and blood results
daughters bloods just received - underactive Hashi's
