I wondered if anyone could answer a question for me?
In 2012 I was tested for Thyroid Peroxidase antibodies which came back positive, and Hashimoto's equates to the presence of antibodies to thyroid peroxidase. Previously I seem to remember that the enzyme Thyroid Peroxidase is involved in the conversion of T4 to T3, though can't quite remember where I read it.
Recently I read that there are 3 enzymes / genes involved in the conversion of T4 to T3, which are the Deiodinases (D1, D2 and D3). However, they then go on to say that deiodinase is a peroxidase enzyme which is involved in the activation or inactivation of thyroid hormones.
So I was wondering if the TPO antibodies tested for are the deiodinase enzymes that are being referred to as D1, D2 and D3?
And if it is whether it varies between them, such that they are specific to D1, D2 or D3?
Why I'm wondering is that I also read that some of the enzymes just convert T4 to T3 whilst others may convert to rT3 (inactive) so I was wondering if the presence of the antibodies / or poor functioning to one conversion path leaves you over reliant to a another less reliable pathway (as can get T3 or rT3)?
The other idea is that rT3 is like a Scottish £10 note (from cash converters) that you can't spend and £10 (T3) you can (from the bank), so it might look like you've withdrawn £20, your balance (T4) has decreased by that much but in some cases you can't use it. I was wondering if one of the pathway's is like cash converters (might be able to use but might not) and one is like the bank?
Are my hypothyroid symptoms because my metabolic currency in circulation is low (T3) or based on an unreliable pathway, such that I have a large number of Scottish £10 notes in circulation (rT3) that I can't use?
Many thanks, reading raises thousands of questions and apologies for my weird way of thinking