Thank you for your reply. Yes sure, see pic.Then also Cortisol Range is 73.8 - 507.0
I'm on 100mg Thyroxine at mo.
I've been really struggling with weight, emotions and waking most mornings with a pain on right side of throat at top which when I trace the pain it leads to my thyroid, sometimes worse than others, also it does wear off after half hour or so...this is the reason for my test too...would you know of any explanation? So appreciate your help regards this.
So your results show you are on slightly to much levo and not converting it well to fT3 which is the active hormone, conversion does tend to suffer when fT4 is too high, I'd suggest lowering your dose a little as above range fT4 is not good long term
Worth alternating 75/100 or if you can 87.5mcg daily whichever is easier to achieve, if you only have 100mcg pills then splitting in half and taking 100mcg 5 days a week and 50mcg 2 days is an option
TSH 0.4 mIU/L (0.27 - 4.2) 3.3%
Free T4 (fT4) 23.3 pmol/L (12 - 22) 113.0%
Free T3 (fT3) 4.9 pmol/L (3.1 - 6.8) 48.6%
T4:T3 Ratio 4.755
Do you have any results for folate, ferritin, Vit D and B12 as these are important to aid conversion
Your raised antibodies confirm that you have autoimmune hypothyroidism and your thyroid is under attack, many find it beneficial to take gluten and or dairy out of their diet
Looking at your blood results and that you left out your levothyroxine med prior to your test I’d say you need to reduce your T4 levo dose. Too much T4 can give all sorts of symptoms. Instead of 100mcg a day try alternating 100 one day then 75 the next and so on. See how you feel after 10 days or so when the level drops. Then retest a month later. You might need to get lower strength tablets to help you do it if you’ve only got 100mcg ones. Or get a scalpel and cut your 100 mcg’s up.
I suggested approx 6 weeks. I said see how you feel after 10 days or so then retest a month after that. I think 6 weeks is plenty of time to see where your levels drop to with levothyroxine myself. And if it’s T3 your changing 2 weeks is enough to see where that level changes to. I’ve been testing my bloods routinely now for 6 years. Mostly I do every 12 weeks without fail by the NHS but there has been times when my med doses have altered and my private Endo suggested 6 weekly.
You definitely needed that increase! My NHS GP will test 6 weekly after a dose change but at a push. He is brilliant though and checks my thyroid levels every 12 weeks without fail along with vitamins and others too. I think I’m lucky reading others posts.
These blood test would appear to be saying that you have Hashimoto's - which is a thyroid Auto Immune disease and presumably the cause of your hypothyroidism.
We generally feel best when the T4 is up in the top quadrant at around 80% through its range with the T3 tracking just behind at around 70% through its range.
Currently your T4 is a little too high at 113% with your T3 at just 48.60 % - and you are not converting well the T4 into T3 - which is the active hormone that runs all your body and brain functionality.
Put another way - once the T4 is up in the top quadrant -
the accepted conversion ratio is said to be 1 / 3.50 - 4.50 - T3/T4 - with most people feeling at their best when they come in this ratio at 4 or under -
so if I divide your T4 result of 23.30 by your T3 result of 4.90 I'm getting your conversion coming in at 4.75 - so a little wide of the centre - showing your body struggling to convert the T4 into T3.
Conversion of T4 into T3 can be compromised by low low core strength vitamins and minerals, but this doesn't look to be an issue -
Conversion can also be down regulated by inflammation, antibodies, any physiological stress ( physical or emotional ) depression, dieting and ageing. - so I think we may have a few issues here -
your inflammation and antibodies are over range showing your body at a level of stress -
and just wondering if the introduction of this new drug Ramipril might be upsetting your body since you are experiencing these new side effects - though I can't see a direct contraindication with thyroid hormone replacement - it has more than its fair share of potential side effects -
How long have you been diagnosed with Hashimoto's Auto Immune thyroid disease and on this dose of T4 - and do you have T3/T4 readings from before starting this new drug ?
The logical first step is to suggest a dose reduction in T4 to get this back to around 80% through the range but this may reduce your already too low a level of T3 ?
With Hashimoto's it is suggested that you get checked out for food sensitivities such as gluten, dairy, wheat - whilst eating your preferred foods as there tends to be stomach and gut intolerance to certain foods which can cause poor gut function and stomach issues which in turn can compound the absorption and utilisation of thyroid hormone replacement.
and if new to Hashimoto's you might like to read around on the website of Dr Izabella Wentz who writes as thyroidpharmacist.com
Thank you very much. I haven't been diagnosed with Hashimoto, must admit I had an inkling I could have it. It's such a job balancing everything with all the ailments I have and the other auto immune diseases. I've been on 100mg for about 6 years now.Will definitely read Dr Izabella
I like to go ‘low and slow’ when making adjustments with thyroid medication, either when increasing or decreasing. Rather than reduce from 100mcg to 75mcg in one go, try alternate days of 100/ 75 first, or use a pill cutter and reduce by 12.5mcg daily.
Some members like to have a coeliac test before commencing a GF trial- you need to be eating gluten if you have the test. Whilst I’m not coeliac, like many on the forum, I’m certainly gluten intolerant and found a 3 month GF trial so useful that I won’t touch it again!
I wouldn’t eliminate both gluten and milk at the same time…. Otherwise it’s hard to work out which (if any) is beneficial to you.
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