Second blood test - subclinical? Please help! - Thyroid UK

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Second blood test - subclinical? Please help!

littlebluegnome profile image
8 Replies

Hello,

I posted here a while ago with results from a Monitor My Health blood test and got some really helpful replies. It was also suggested that I do a full test to get a better picture so I did the Medichecks Advanced Thyroid Function Blood Test and have just got the results - they are saying I may have 'subclinical' hypothyroid, but it also looks like my results have changed quite a bit since the Monitor My Health test I did about 6 months ago. I also had a blood test at the doctor's around 10 years ago where the doctor throught my results were slightly abnormal but not at a point where she thought treatment was needed but I was sure I had symptoms then and still have loads of symptoms now as well as a family history of it.

I would really appreciate any help interpreting what my results mean and any suggestions on what to do next, my last post is also on my profile. Thank you!!

Monitor My Health - July 2023

TSH levels normal (normal range 0.27 - 4.2 mU/L) - Your result is 2.74

FT3 levels normal (normal range 3.1 - 6.8 pmol/L) - Your result is 4.6

FT4 levels normal (normal range 12 - 22 pmol/L) - Your result is 13.2

Medichecks - Jan 2024 (done at 9am after only water)

Thyroid Hormones

TSH X 5.640 mIU/L (Range: 0.27 - 4.2)

Free T3 6.0 pmol/L (Range: 3.1 - 6.8)

Free Thyroxine 14.0 pmol/L (Range: 12 - 22)

Inflammation

CRP HS 2.360 mg/L (Range: < 3)

Iron Status

Ferritin 54.60 ug/L (Range: 30 - 180)

Vitamins

Folate - Serum 12.3 nmol/L (Range: > 7)

Vitamin B12 - Active 63.8 pmol/L

Please note change of reference range 23 Oct 2022

(Range: 37.5 - 188)

Vitamin D X 20.2 nmol/L

Total 25(OH) vitamin D < 25 nmol/L is deficient.

Total 25(OH)D of 25-50 nmol/L may be inadequate in some people.

Total 25(OH)D > 50 nmol/L is sufficient in most individuals.

Total Vitamin D level >250 nmol/L - indicates potential for toxiPlease note change of reference range 23 Oct 2022

(Range: 50 - 250)

Autoimmunity

Thyroglobulin Antibodies 14.90 kIU/L (Range: 0 - 115)

Thyroid Peroxidase Antibodies <9 kIU/L (Range: 0 - 34)

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8 Replies
Jaydee1507 profile image
Jaydee1507Administrator

Your latest results show that your TSH has risen above the range showing that you are hypothyroid.

Have you had positive antibody results on the past? Currently your result is negative.

You should show these reults to your GP andhopefully they will repeat the thyroid tests on the NHS. You need 2 above range TSH results 3 months apart on the NHS to get a diagnosis and begin treatment.

Again with your vit D result it is very low. Show this to your GP who may want to repeat the test and should offer loading doses of D3. Once you have finished those you should buy a vit D3 + K2 supplement and continue supplementing yourself.

B12 & folate are a little on the low side. You would benefit from taking a good methyl/active type B complex to help keep all the B's in balance.

Slightly cheaper options with inactive B6:

amazon.co.uk/Liposomal-Soft...

Contains B6 as P5P an active form:

bigvits.co.uk/thorne-resear...

healf.com/products/basic-b-...

Explanation about the different forms of B6:

helvella.blogspot.com/p/hel...

B complex comparison spreadsheet:

healthunlocked.com/thyroidu...

Ferritin should be around 90 - 100 for best use of thyroid hormone. Suggest increasing iron rich foods in diet and eating them often. Chicken livers, pate, red meat etc

littlebluegnome profile image
littlebluegnome in reply to Jaydee1507

Thank you for all the information! I don't think I've had antibody tests before, would positive give a better idea what the problem could be?

Jaydee1507 profile image
Jaydee1507Administrator in reply to littlebluegnome

Positive antibodies would say for sure you have autoimmune thyroid issues also known as Hashimoto's. That said a small percentage of people with Hashi's never have positive antibodies, known as seronegative.

Do retest them from time to time as you never know they might be positive at some point.

SlowDragon profile image
SlowDragonAdministrator

Low vitamin levels tend to lower TSH

So it’s essential to improve low vitamin levels

Low vitamin levels are a direct result of being hypothyroid…so it’s chicken and egg

Vitamin D X 20.2 nmol/L

GP should prescribe 300,000iu in total over 6-8 weeks

NHS Guidelines on dose vitamin D required

ouh.nhs.uk/osteoporosis/use...

GP will often only prescribe to bring vitamin D levels to 50nmol.

Some areas will prescribe to bring levels to 75nmol or even 80nmol

leedsformulary.nhs.uk/docs/...

GP should advise on self supplementing if over 50nmol, but under 75nmol (but they rarely do)

mm.wirral.nhs.uk/document_u...

But with Hashimoto’s, improving to around 80nmol or 100nmol by self supplementing may be better

pubmed.ncbi.nlm.nih.gov/218...

vitamindsociety.org/pdf/Vit...

Once you Improve level, very likely you will need on going maintenance dose to keep it there.

Test twice yearly via NHS private testing service when supplementing

vitamindtest.org.uk

Vitamin D mouth spray by Better You is very effective as it avoids poor gut function.

There’s a version made that also contains vitamin K2 Mk7.

One spray = 1000iu

amazon.co.uk/BetterYou-Dlux...

It’s trial and error what dose we need, with thyroid issues we frequently need higher dose than average

Vitamin D and thyroid disease

grassrootshealth.net/blog/t...

Vitamin D may prevent Autoimmune disease

newscientist.com/article/23...

Web links about taking important cofactors - magnesium and Vit K2-MK7

Magnesium best taken in the afternoon or evening, but must be four hours away from levothyroxine

betterbones.com/bone-nutrit...

medicalnewstoday.com/articl...

livescience.com/61866-magne...

sciencedaily.com/releases/2...

Interesting article by Dr Malcolm Kendrick on magnesium

drmalcolmkendrick.org/categ...

Vitamin K2 mk7

betterbones.com/bone-nutrit...

healthline.com/nutrition/vi...

SlowDragon profile image
SlowDragonAdministrator

Low B12 symptoms

b12deficiency.info/signs-an...

methyl-life.com/blogs/defic...

With serum B12 result below 500, (Or active B12 below 70) recommended to be taking a separate B12 supplement and a week later add a separate vitamin B Complex 

Then once your serum B12 is over 500 (or Active B12 level has reached 70), you may be able to reduce then stop the B12 and just carry on with the B Complex.

If Vegetarian or vegan likely to need ongoing separate B12 few times a week

Highly effective B12 drops

natureprovides.com/products...

Or

B12 sublingual lozenges

uk.iherb.com/pr/jarrow-form...

cytoplan.co.uk/shop-by-prod...

B12 range in U.K. is too wide

Interesting that in this research B12 below 400 is considered inadequate

healthunlocked.com/thyroidu...

Low folate

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid)

This can help keep all B vitamins in balance and will help improve B12 levels too

Difference between folate and folic acid

healthline.com/nutrition/fo...

B vitamins best taken after breakfast

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule)

Thorne currently difficult to find at reasonable price, should be around £20-£25. iherb.com often have in stock. Or try ebay

Igennus B complex popular option too. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose

Post discussing different B complex

healthunlocked.com/thyroidu...

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg) and continue separate B12 until over 70

Post discussing how biotin can affect test results

healthunlocked.com/thyroidu...

helvella.blogspot.com/p/hel...

SlowDragon profile image
SlowDragonAdministrator

Starting levothyroxine - flow chart

gps.northcentrallondonccg.n...

you need two blood tests with TSH over 5

all thyroid blood tests early morning, ideally just before 9am, only drink water between waking and test

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

SlowDragon profile image
SlowDragonAdministrator

also 20% of Hashimoto's patients never have raised antibodies

healthunlocked.com/thyroidu...

Paul Robson on atrophied thyroid - especially if no TPO antibodies

paulrobinsonthyroid.com/cou...

Gluten intolerance is often a hidden issue too.

Request coeliac blood test BEFORE considering trial on strictly gluten free diet

littlebluegnome profile image
littlebluegnome in reply to SlowDragon

Thank you for such an incredible amount of information! I'll work my way through all the links today 😀

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