This is my first post, but having been reading lots of posts both here and on the pernicious anaemia group. I've had a lot of tests and I unsure how to proceed. Apologies in advance for the long post.
I'm 38, female, BMI 31 and my health seems to be getting progressively worse. Up until September I was working in a senior/board level position, but was signed off by GP for 2 months with stress-induced depression. I was already on 20mg of citalopram, and have been since the birth of my son 7 years ago. This was increased to 40mg. After suffering from horrendous insomnia for 2 months on this dose despite trialling different times of day, I cut this down myself to 30mg. I have subsequently told my employer that I will not be returning to work as I don't feel able to and thankfully my husband is in a position to support us financially.
My mood has improved (relatively), but my other symptoms are getting a lot worse: extreme tiredness, lack of energy, breathlessness, weight gain (size 8 to 16 in 2 years), almost constant heartburn, restless leg, eye twitching, no periods for 6+ months, difficulty concentrating, very poor memory (for example, this morning I put on toast for breakfast then completely forgot about it), irritability, light and sound sensitivity. I think there are more, but I'm struggling to think straight right now.
My GPs diagnosis: Depression and PCOS (due to hirsutism). Sex hormones have been tested and menopause ruled out.
My initial suspicion was hypothyroidism, so I purchased test from Blue Horizon:
5/12/16 / 10.15am / Finger prick
Ferritin 30.1 ug/L (20 - 150)
TSH 2.71 mIU/L (0.27 - 4.5)
Free T4 13.91 pmol/L (12 - 22)
Free T3 4.85 pmol/L (3.1 - 6.8)
Anti-Thyroidperoxidase abs 16.9 kIU/L (< 34)
Anti-Thyroglobulin abs 10.3 kU/L (< 110)
Vitamin D (25 OH) 32 nmol/L (insufficient 25 - 50)
Vitamin B12 149 pmol/L (insufficient 140 - 250)
Serum Folate 4.4 nmol/L (8.83 - 60.8)
The sample I provide was insufficient to test CRP and Total T4, so I provided another sample a couple of days later:
CRP 15.7 mg/L (< 5)
Total T4 106.4 nmol/L (64.5 - 142)
My GP says thyroid is normal and is very dismissive of the B12/Folate/CRP values. He says he's "seen much worse" and that "B12 deficiency would not cause extreme tiredness". His only advice at this stage was to supplement vit D, although he did agree to do more blood tests.
5/12/16 / 11:48am / Venous sample
Bone profile - normal
Urea & Electrolytes - normal
Liver function - normal
I can provide specific values for the above if you think it would help?
TSH 2.07 mU/L (0.35 - 5.0)
Free T4 pmol/L (9.0 - 21.0)
Vit D (25 OH) 33 nmol/L (insufficient 25 - 50)
My GP 'forgot' to tick the boxes for B12, folate and Ferritin, so I had another sample taken on 14/12 at 17:31pm:
Serum B12 240 ng/l (200 - 900)
Serum Ferritin 25 ug/L (15 - 200)
Serum Folate 3.1 ug/L (3.1 - 20)
CRP 19 mg/L (0 - 10)
Prolactin 177 (<<630)
I also had a full blood count, with the only figure not in range being:
MCH 26.9 pg (27.0 - 32.0)
MCV was 86.8 fl (80.0 - 100.0). No blood film taken.
If you've made it this far, thank you! I would really appreciate your thoughts on how to proceed. I am not at all opposed to self-treating if necessary, but want to ensure that I'm doing the right thing. I'd really like to get well and have another child if at all possible. Sudden, severe pre-eclampsia and premature delivery at 31 weeks with my son has convinced me that I need to be in the best possible health before I even think of trying to conceive!