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BAT therapy - NIH article
Efficacy and safety of bipolar androgen therapy in castration-resistant prostate cancer following abiraterone or enzalutamide resistance: A systematic review. You X, Huang S, Wang X, Yi C, Gong N, Yu J, Xu C, Xiang Z. Front Endocrinol (Lausanne). 2023 Apr 11;13:1125838. doi: 10.3389/fendo.2022.1125838
Efficacy and safety of bipolar androgen therapy in castration-resistant prostate cancer following abiraterone or enzalutamide resistance: A systematic review. You X, Huang S, Wang X, Yi C, Gong N, Yu J, Xu C, Xiang Z. Front Endocrinol (Lausanne). 2023 Apr 11;13:1125838. doi: 10.3389/fendo.2022.1125838
Magnus1964
in
Advanced Prostate Cancer
1 year ago
steroid inhalers and oral thrush
hi I am really struggling with my steroid inhaler as I am constantly getting thrush at the back of my mouth ( I have it constantly under my top lip ) I have ME / CFS and have seen an immunologist ( some abnormal bloods but nothing specific found ! ) I take vits/ minerals : good diet I use a spacer
hi I am really struggling with my steroid inhaler as I am constantly getting thrush at the back of my mouth ( I have it constantly under my top lip ) I have ME / CFS and have seen an immunologist ( some abnormal bloods but nothing specific found ! ) I take vits/ minerals : good diet I use a spacer
Skydog70
in
Asthma Community Forum
1 year ago
10 Year Anniversary
A few weeks ago I realized this is the ten-year anniversary of when I started dialysis. I started in August of 2013 in the days after I had a knee surgery. I was 14 years old. I'm now 24 years old. In the time since I started dialysis I started and finished high school, started and finished college,
A few weeks ago I realized this is the ten-year anniversary of when I started dialysis. I started in August of 2013 in the days after I had a knee surgery. I was 14 years old. I'm now 24 years old. In the time since I started dialysis I started and finished high school, started and finished college,
StormCl0ud
in
Kidney Dialysis
1 year ago
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Root canal and teeth Implants
Hi all, I have an infected tooth, went to see d dentist n he said he will do a root canal for me, but I ve heard that Root canals are bad for lupus. Do anyone know about this? Thanks.
Hi all, I have an infected tooth, went to see d dentist n he said he will do a root canal for me, but I ve heard that Root canals are bad for lupus. Do anyone know about this? Thanks.
Knowledgeispower1
in
LUPUS UK
1 year ago
Aplautamide, enzalutamide: low dose opinions
Hi Officially mcrpc. Can't get darolutamide so faced with choice of zytiga, xtandi or aplautamide in the coming weeks. Faced with the first two I would have opted for xtandi and hopefully worked towards taking two tablets. Maybe one but have seen a few progress at one and wonder if two would be an
Hi Officially mcrpc. Can't get darolutamide so faced with choice of zytiga, xtandi or aplautamide in the coming weeks. Faced with the first two I would have opted for xtandi and hopefully worked towards taking two tablets. Maybe one but have seen a few progress at one and wonder if two would be an
Rickytarr
in
Fight Prostate Cancer
1 year ago
Aging: Papers on diet, exercise, and caloric restriction effects on microbiome and epigenome
The following two articles were included in post by a member over at the HU CLLSupport site. (Thanks, Kwenda.) Both are review papers that look at the effects of diet and exercise on health outcomes. The second paper is much more technical in nature and is from researchers in Portugal. I'm including
The following two articles were included in post by a member over at the HU CLLSupport site. (Thanks, Kwenda.) Both are review papers that look at the effects of diet and exercise on health outcomes. The second paper is much more technical in nature and is from researchers in Portugal. I'm including
cujoe
in
Fight Prostate Cancer
1 year ago
THRUSH
I am an old man. For the last 2 years I have had thrush as diagnosed by my doc. I have tried Canesten and Lexerma they work temporarily but are otherwise useless, . A special (expensive) shower gel- is equally useless. It is no big deal and does not affect my life really but won't go away mildly painful
I am an old man. For the last 2 years I have had thrush as diagnosed by my doc. I have tried Canesten and Lexerma they work temporarily but are otherwise useless, . A special (expensive) shower gel- is equally useless. It is no big deal and does not affect my life really but won't go away mildly painful
VictorMc
in
Men's Health Forum
1 year ago
Ongoing unknown sickness. 26F. 49.5kg and 5ft 8. Non-smoker. Only medication is oral contraception.
F 26 undiagnosed sickness on and off for 4 months - night sweats, sore throat, diarrhoea, general fatigue, oral thrush I have been getting sick on and off since December. I work as a primary school teacher so exposure to viruses is the norm but this has been really excessive. I've been diagnosed with
F 26 undiagnosed sickness on and off for 4 months - night sweats, sore throat, diarrhoea, general fatigue, oral thrush I have been getting sick on and off since December. I work as a primary school teacher so exposure to viruses is the norm but this has been really excessive. I've been diagnosed with
catcat333
in
Thyroid UK
1 year ago
new here and looking for help and advice
so 8 weeks ago I started feeling this strange feeling in my back upper teeth on the right side I thought it might be sensitive teeth and bought some sensodyne toothpaste as it was like tingling. I booked a dentist appointment and other than a professional clean my teeth are healthy. I’ve felt this sensation
so 8 weeks ago I started feeling this strange feeling in my back upper teeth on the right side I thought it might be sensitive teeth and bought some sensodyne toothpaste as it was like tingling. I booked a dentist appointment and other than a professional clean my teeth are healthy. I’ve felt this sensation
Lau575
in
Anxiety Support
1 year ago
Caffeic acid phenethyl ester [CAPE]
New study [1]. "
Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells
" There have been 2 dozen CAPE papers these last 20 years. Ten of these specifically mention Akt inhibition. CAPE is found in propolis, which bees use to seal
New study [1]. "
Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells
" There have been 2 dozen CAPE papers these last 20 years. Ten of these specifically mention Akt inhibition. CAPE is found in propolis, which bees use to seal
pca2004
in
Fight Prostate Cancer
1 year ago
Ivermectin on Pub Med
{From a related web site} In summary, our results indicate that ivermectin suppressed the AR and E2F signaling pathways and DNA damage repair capacity by targeting FOXA1 and Ku70/Ku80 to inhibit cell proliferation and promote cell apoptosis in prostate cancer. These findings provide insight into both
{From a related web site} In summary, our results indicate that ivermectin suppressed the AR and E2F signaling pathways and DNA damage repair capacity by targeting FOXA1 and Ku70/Ku80 to inhibit cell proliferation and promote cell apoptosis in prostate cancer. These findings provide insight into both
cigafred
in
Fight Prostate Cancer
1 year ago
Strategies to Re-Sensitize Castration-Resistant Prostate Cancer to Antiandrogen Therapy
New paper from Spain [1]. "... we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of "hinge" treatments with the objective of obtaining an oncological benefit. "
Some examples are:
[i]
bipolar androgen therapy (
New paper from Spain [1]. "... we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of "hinge" treatments with the objective of obtaining an oncological benefit. "
Some examples are:
[i]
bipolar androgen therapy (
pca2004
in
Fight Prostate Cancer
1 year ago
Dry mouth!
I suffer from dry mouth and my dentist prescribed me some toothpaste and a mouth spray but the effect of the spray is not lasting. Can anyone suggest any supplements that might help at all? When my mouth is really dry is cracks at the sides which is quite painful too
I suffer from dry mouth and my dentist prescribed me some toothpaste and a mouth spray but the effect of the spray is not lasting. Can anyone suggest any supplements that might help at all? When my mouth is really dry is cracks at the sides which is quite painful too
Gilliancheche
in
NRAS
1 year ago
Your 'teeth and gums' could be CAUSING your PD!
Even though I had the last of my mercury fillings removed a few months ago... and a root canal on another tooth... I know I need additional dental work that I've been putting off... until I read this:
"Two Cases of Parkinson’s Disease for Which Dental Treatment Was Effective"
https://www.scirp.org
Even though I had the last of my mercury fillings removed a few months ago... and a root canal on another tooth... I know I need additional dental work that I've been putting off... until I read this:
"Two Cases of Parkinson’s Disease for Which Dental Treatment Was Effective"
https://www.scirp.org
PDWarrior1900
in
Cure Parkinson's
2 years ago
Valium RLS
Is anyone using Valium/diazepam or any other benzo to treat RLS? The Horizant that I’ve been using for the last year and a half isn’t working as well as it used to.
Is anyone using Valium/diazepam or any other benzo to treat RLS? The Horizant that I’ve been using for the last year and a half isn’t working as well as it used to.
tagaxel
in
Restless Legs Syndrome
1 year ago
Ughh piles again
Why when I Google internal piles does it tell me they are painless?? The consequence of a flare up of IBS/D is usually some constipation and a struggle to go. This leaves me with piles and makes my bottom feel almost bruised, and like it's got something hot in there! In no way can they be considered
Why when I Google internal piles does it tell me they are painless?? The consequence of a flare up of IBS/D is usually some constipation and a struggle to go. This leaves me with piles and makes my bottom feel almost bruised, and like it's got something hot in there! In no way can they be considered
binks
in
IBS Network
1 year ago
Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition
New paper below [1]. I have always been interested in ways in which a treatment might be enhanced by supplements or dietary changes. (or repurposed drugs) In this case, "depletion of L-cysteine/cystine" was via "an engineered human enzyme, Cyst(e)inase". "PCa cells treated with Cyst(e)inase lead
New paper below [1]. I have always been interested in ways in which a treatment might be enhanced by supplements or dietary changes. (or repurposed drugs) In this case, "depletion of L-cysteine/cystine" was via "an engineered human enzyme, Cyst(e)inase". "PCa cells treated with Cyst(e)inase lead
pca2004
in
Fight Prostate Cancer
1 year ago
Fistula + Stage 4 Endo
Hi, I have ended up in urgent care due to a lump that keeps bleeding in my belly button. I had surgery in 2020 to help remove some of the endometriosis however since then I have always had a slight lump. I thought it was just healing however last couple of months its got bigger, darker and more painful
Hi, I have ended up in urgent care due to a lump that keeps bleeding in my belly button. I had surgery in 2020 to help remove some of the endometriosis however since then I have always had a slight lump. I thought it was just healing however last couple of months its got bigger, darker and more painful
MsTMP
in
Endometriosis UK
1 year ago
Navage?
Many of us (most?) suffer from sinus issues and we have our own tools to deal with these issues. My weapons of choice are Saline spray followed by Flonase before I go to bed. Works pretty well except for right now during allergy season. However, I've been hearing many advertisements for the Navage
Many of us (most?) suffer from sinus issues and we have our own tools to deal with these issues. My weapons of choice are Saline spray followed by Flonase before I go to bed. Works pretty well except for right now during allergy season. However, I've been hearing many advertisements for the Navage
hhk50
in
CLL Support
1 year ago
possible to improve C Telopeptide Serum blood test for risk of osteonecrosis?
Hi, about 5 months ago I took myself off the Xgeva bone drug after being on it about 2 years or so. This was after learning I couldn’t be on it and also have the dental work done that I need to have done (cavitations etc). My personal feeling after doing research over the years is that I’m not able
Hi, about 5 months ago I took myself off the Xgeva bone drug after being on it about 2 years or so. This was after learning I couldn’t be on it and also have the dental work done that I need to have done (cavitations etc). My personal feeling after doing research over the years is that I’m not able
Verbena1
in
Bone Health and Osteoporosis UK
2 years ago
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