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Updating my husband's journey, hoping it helps others - any words of encouragement are welcome, but please only positive comments
The first part is in my profile. It makes me feel vulnerable to share, but we have benefited enormously from reading others' stories, so I'm sharing. UPDATE: 8/18/21 PSA =0.45 9/6/21 last dose Orgovyx 9/7/21 First Eligard 3 month shot 9/17/21 PSA =0.78 10/18/21 PSA =1.28 Nov not tested 12
The first part is in my profile. It makes me feel vulnerable to share, but we have benefited enormously from reading others' stories, so I'm sharing. UPDATE: 8/18/21 PSA =0.45 9/6/21 last dose Orgovyx 9/7/21 First Eligard 3 month shot 9/17/21 PSA =0.78 10/18/21 PSA =1.28 Nov not tested 12
SuppWife
in
Advanced Prostate Cancer
4 months ago
Relugolix/Orgovyx or Enzalutamide/Xtandi?
Good morning, all. I have updated my profile with my husband's history. But, long story short, he has been on ADT vacation for 13 months following succesful treatment of metastatic disease with Triplet Therapy (six rounds of Docetaxel, Lupron, and first Abieraterone plus Prednisone and then he switched
Good morning, all. I have updated my profile with my husband's history. But, long story short, he has been on ADT vacation for 13 months following succesful treatment of metastatic disease with Triplet Therapy (six rounds of Docetaxel, Lupron, and first Abieraterone plus Prednisone and then he switched
FaithOverFear104
in
Advanced Prostate Cancer
4 months ago
Pet Scan = "disease not detected"
Ok folks, has anyone come across something like this?...early 2018, PSA in the 50's, biopsy came back negative, a few months later PSA in the 60's, again, another biopsy and a negative finding, 3rd time in the 80's with yet another negative biopsy, then nuclear imaging and bam...stage 4 metastatic, this
Ok folks, has anyone come across something like this?...early 2018, PSA in the 50's, biopsy came back negative, a few months later PSA in the 60's, again, another biopsy and a negative finding, 3rd time in the 80's with yet another negative biopsy, then nuclear imaging and bam...stage 4 metastatic, this
GreyDragon55
in
Advanced Prostate Cancer
4 months ago
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Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Advanced Prostate Cancer
4 months ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Prostate Cancer Network
4 months ago
Doubling Times and PSA acceleration - Part II
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
janebob99
in
Prostate Cancer Network
5 months ago
Baseline PSMA-Pet scan?
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
duxlubber
in
Advanced Prostate Cancer
5 months ago
Revised Plot of PSA vs Testosterone: Estrogen vs Lupron ADT
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
janebob99
in
Advanced Prostate Cancer
5 months ago
Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
5 months ago
Enzalutamide vs Lupron Survival
This shows the main results of the EMBARK trial, comparing Metatasis Free Survival and PSA Recurrence Free Survival for three groups: Enzalutamide only, Lupron only, or combined Enzalutamide + Lupron. The best survivals were for the combination of Enzalutamide + Lupron. Enzalutamide is a 2nd generation
This shows the main results of the EMBARK trial, comparing Metatasis Free Survival and PSA Recurrence Free Survival for three groups: Enzalutamide only, Lupron only, or combined Enzalutamide + Lupron. The best survivals were for the combination of Enzalutamide + Lupron. Enzalutamide is a 2nd generation
janebob99
in
Prostate Cancer Network
5 months ago
Do testosterone supplements help raise testosterone levels after use of Lupron with radiation?
trying to decide to decide between surgery and radiation w/Lupron as a treatment for prostate cancer. I’m particularly concerned with how long it takes to restore testerone levels after 6 months on Lupron. Does the use of testerone supplements help restore T levels more quickly?
trying to decide to decide between surgery and radiation w/Lupron as a treatment for prostate cancer. I’m particularly concerned with how long it takes to restore testerone levels after 6 months on Lupron. Does the use of testerone supplements help restore T levels more quickly?
Godfather2
in
Prostate Cancer Network
5 months ago
Gummie relief for degarelix shots?
DH has so much pain with each monthly shot and can't take nsaids. Is there anything that won't make him loopy to use after shots for a few days? He is ready to go back to lupron, it hurts so much. Mail order preferred.Thanks!
DH has so much pain with each monthly shot and can't take nsaids. Is there anything that won't make him loopy to use after shots for a few days? He is ready to go back to lupron, it hurts so much. Mail order preferred.Thanks!
Chipnick
in
Advanced Prostate Cancer
5 months ago
PSA now undetectable with 2 of 35 radiation treatments left.
PSA now undetectable with 2 of 35 radiation treatments left to complete. I will start Abiraterone next week, in addition to the Lupron I’m currently on. I’m celebrating today’s victory and wanted to share here. Of course, many days have been consumed with worry over the unknown. This group has been
PSA now undetectable with 2 of 35 radiation treatments left to complete. I will start Abiraterone next week, in addition to the Lupron I’m currently on. I’m celebrating today’s victory and wanted to share here. Of course, many days have been consumed with worry over the unknown. This group has been
Stereo1
in
Advanced Prostate Cancer
5 months ago
Docxtel triple therapy?
Thank you for sharing your thoughts. My dad--81, advanced metastatic castrate resistant Diagnosed at 79 with stage 4 met 8 bones, including skull, no Gleason, never even saw a urologist. Diagnosed in ER and sent straight to the oncologist and palliative care doctor. PSA initially at 137 Lupron
Thank you for sharing your thoughts. My dad--81, advanced metastatic castrate resistant Diagnosed at 79 with stage 4 met 8 bones, including skull, no Gleason, never even saw a urologist. Diagnosed in ER and sent straight to the oncologist and palliative care doctor. PSA initially at 137 Lupron
lgutman
in
Advanced Prostate Cancer
5 months ago
Triplet and now Radiation?
Hi all - just wanting your thoughts on this. In my profile you would see full details but I will summarize here. 50yr old diagnosed Aug 2nd with PCA with spread to L5 and pubic bone. Original PSA was around 9 and put on Casodex for month, then Lupron every 3 months, plus Darolutamide. Just completed
Hi all - just wanting your thoughts on this. In my profile you would see full details but I will summarize here. 50yr old diagnosed Aug 2nd with PCA with spread to L5 and pubic bone. Original PSA was around 9 and put on Casodex for month, then Lupron every 3 months, plus Darolutamide. Just completed
Yzinger
in
Advanced Prostate Cancer
5 months ago
Removal of contralateral testicle
To further reduce risk of recurrence of NHL DLBCL the contralateral testicle was removed as well. Surgery was successful. Now waiting two months and then check PSA and Testosterone. Still hormone sensitive, but no further Lupron required. Looking forward.
To further reduce risk of recurrence of NHL DLBCL the contralateral testicle was removed as well. Surgery was successful. Now waiting two months and then check PSA and Testosterone. Still hormone sensitive, but no further Lupron required. Looking forward.
Nusch
in
Advanced Prostate Cancer
5 months ago
Early Results from Transdermal Estrogen PATCH trial - 2
Here's some charts comparing Lupron ADT to transdermal estrogen (TDE) therapy for High Risk and Very High Risk men with prostate cancer. The upper chart shows the percentage of men that have been castrated to a testosterone level < 50 ng/dL after 1 month of treatment. For Lupron, only 65% of HR/VHR
Here's some charts comparing Lupron ADT to transdermal estrogen (TDE) therapy for High Risk and Very High Risk men with prostate cancer. The upper chart shows the percentage of men that have been castrated to a testosterone level < 50 ng/dL after 1 month of treatment. For Lupron, only 65% of HR/VHR
janebob99
in
Prostate Cancer Network
5 months ago
Early Results from Transdermal Estrogen PATCH trial - 2
Here's some charts comparing Lupron ADT to transdermal estrogen (TDE) patch therapy for High Risk and Very High Risk men with prostate cancer. The upper chart shows the percentage of men that have been castrated to a testosterone level < 50 ng/dL after 1 month of treatment. For Lupron, 65% of HR/
Here's some charts comparing Lupron ADT to transdermal estrogen (TDE) patch therapy for High Risk and Very High Risk men with prostate cancer. The upper chart shows the percentage of men that have been castrated to a testosterone level < 50 ng/dL after 1 month of treatment. For Lupron, 65% of HR/
janebob99
in
Advanced Prostate Cancer
5 months ago
Early Results from Transdermal Estrogen PATCH trial
Here are some Early Results from the first year of the Transdermal Estrogen PATCH trial. References are available on their website at: http://patch.mrcctu.ucl.ac.uk. The cohort was men with High or Very High Risk prostate cancer. Stage T3 (73%) and Stage T4 (14%), baseline PSA = 35 ng/mL. The upper
Here are some Early Results from the first year of the Transdermal Estrogen PATCH trial. References are available on their website at: http://patch.mrcctu.ucl.ac.uk. The cohort was men with High or Very High Risk prostate cancer. Stage T3 (73%) and Stage T4 (14%), baseline PSA = 35 ng/mL. The upper
janebob99
in
Advanced Prostate Cancer
5 months ago
Early Results of Estrogen PATCH trial - 1
Here are some Early Results from the first year of the Transdermal Estrogen PATCH trial. References are available on their website at: http://patch.mrcctu.ucl.ac.uk. The cohort was men with High or Very High Risk prostate cancer. Stage T3 (73%) and Stage T4 (14%), baseline PSA = 35 ng/mL. The upper
Here are some Early Results from the first year of the Transdermal Estrogen PATCH trial. References are available on their website at: http://patch.mrcctu.ucl.ac.uk. The cohort was men with High or Very High Risk prostate cancer. Stage T3 (73%) and Stage T4 (14%), baseline PSA = 35 ng/mL. The upper
janebob99
in
Prostate Cancer Network
5 months ago
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