Early Results of Estrogen PATCH trial - 1

[janebob99]

Here are some Early Results from the first year of the Transdermal Estrogen PATCH trial. References are available on their website at: patch.mrcctu.ucl.ac.uk.

The cohort was men with High or Very High Risk prostate cancer. Stage T3 (73%) and Stage T4 (14%), baseline PSA = 35 ng/mL.

The upper chart shows the % change in a given measurement after 12 months of treatment, comparing Lupron ADT to high-dose transdermal estrogen (TDE) patch. The biggest improvements with using TDE are reductions in: blood glucose, cholesterol, and blood pressure, and increases in HDL. No increases in adverse Cardio Vascular Events (CVE) were observed in the TDE arm, supporting the safety of doing Transdermal Estrogen versus the older Oral Estrogen treatment (from 1950 to 1980), which had problems with blood clots.

The lower chart shows significantly reduced Hot Flashes with TDE therapy. Unfortunately, the incidence of gynecomastia (enlarged breasts) was significantly higher with TDE therapy.

Bob