This shows the main results of the EMBARK trial, comparing Metatasis Free Survival and PSA Recurrence Free Survival for three groups: Enzalutamide only, Lupron only, or combined Enzalutamide + Lupron.
The best survivals were for the combination of Enzalutamide + Lupron.
Enzalutamide is a 2nd generation Anti-Androgen, and Lupron is an anti-testosterone agent.
Thank you.I always look forward to your posts
it’s a great tandem no doubt. Side effects often much tougher though and definitely not for everyone.
What are the main side effects?
From the study..... " The safety profile of enzalutamide was consistent with that shown in previous clinical studies, with no apparent detrimental effect on quality of life." If adding enzalutamide does not add significantly to QOL problems, that is one thing. If the combo actually has a more concerning QOL profile, then, to me, The enzalutamide monotherapy provides just slightly less desirable results than the combo, and I would be tempted to go that route?
Thanks for everything you are providing to folks here!!!
By metastasis-free, does it mean patients had no Mets at beginning of trial, or simply that the Mets they did have didn't grow?
Good question. I think "Metatasis-Free" means free from Mets at the beginning of the trial.
The summary of the paper says: "In this phase 3 trial, we enrolled patients with prostate cancer who had high-risk biochemical recurrence with a prostate-specific antigen doubling time of 9 months or less." It doesn't say, but I'm assuming that there are no mets at the beginning. But, the short PSA doubling time (DT) means that they have active prostate cancer growing.
Bob thanks for the info but after looking at your graphs I was left with one burning question.
Are the the results statically significant? Those numbers are pretty close on casual observation except for the Lupron only leg.
Good point.
I went back to the source document to see how many men were studied, and n = 1068 total. So, good statistics.
One main takeaway is that there isn't much difference between Enzulatimide Alone and Enzulatimide + Lupron. The difference is in the noise.
I don't know if the side effects of Enzulatime Alone are less than Lupron. I would think so. Maybe someone could weigh in on this?
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