Docxtel triple therapy?

[lgutman]

Thank you for sharing your thoughts.

My dad--81, advanced metastatic castrate resistant

Diagnosed at 79 with stage 4 met 8 bones, including skull, no Gleason, never even saw a urologist. Diagnosed in ER and sent straight to the oncologist and palliative care doctor. PSA initially at 137

Lupron every six months

Bicalutamide worked for about 8-9 months

Moved to Xtandi to avoid steriods due to severe glacoma stopped working at 4 months

Radiation to the back.

Xtandi just failed, PSA has been doubled over 8 weeks and then over the next 4 weeks. He had severe pain in his shoulders and neck and was hospitalized. We start radiation the week of March 11 and are currently waiting on the PETSCAN to change meds.

The oncologist pharmacist called and talked to him, will most likely switch to Zytiga + steriod can consider Docxtell.

I read that when the above three are combined it normally gives the best results, versus starting the chemo after? My dad was against chemo but I am thinking he might change his mind.

He has a lot of comorbidities as well as his RBC is like 3.8

What are the blood requirements that are needed for docxtell?

The initial CT scans on this most recent trip to hospital showed the cancer spread both where it was before and to new areas and new mets on the skull. I am hoping the petscan shows still no liver involvment. My dad is really frail these days and the pharmacist said swithing from Xtandi may help a little with this.

I would love your thoughts. Thanks!

[Tall_Allen]

Consider enzalutamide+ docetaxel:

prostatecancer.news/2022/10...

Ask his oncologist if his blood work is good enough for docetaxel.