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Input on Timing of Initial ADT after RP/SRT Failed
After surgery and salvage radiation therapy (SRT) have failed, it appears I'm headed for androgen deprivation therapy. Like many things in the world of prostate cancer, the recommendations as to when to start ADT seem to be all over the place, so I'm seeking any insights folks may have based on your
After surgery and salvage radiation therapy (SRT) have failed, it appears I'm headed for androgen deprivation therapy. Like many things in the world of prostate cancer, the recommendations as to when to start ADT seem to be all over the place, so I'm seeking any insights folks may have based on your
dans_journey
in
Advanced Prostate Cancer
5 months ago
Phase 1 trial shows promising results for fractionated dose of 225Ac-J591 in PCa treatment
The fractionated dosing achieved promising results with 95% of patients experiencing any PSA decline and 71% achieving a PSA50 response. In contrast, the multiple cycles cohort saw 72% of patients with any PSA decline and 28% achieving a PSA50 response...fractionate good! https://www.urotoday.com/conference-highlights
The fractionated dosing achieved promising results with 95% of patients experiencing any PSA decline and 71% achieving a PSA50 response. In contrast, the multiple cycles cohort saw 72% of patients with any PSA decline and 28% achieving a PSA50 response...fractionate good! https://www.urotoday.com/conference-highlights
Maxone73
in
Advanced Prostate Cancer
5 months ago
177Lu-PSMA-617: Trial shows it's more effective than changing ARPIs
"Patients who enrolled in the trial were assigned to either a change in ARPI, for example from abiraterone to enzalutamide or vice versa, or 177Lu-PSMA-617, a prostate-specific antigen (PSMA)-targeted radioligand therapy. This analysis found that treatment with 177Lu-PSMA-617 prolonged radiographic progression-free
"Patients who enrolled in the trial were assigned to either a change in ARPI, for example from abiraterone to enzalutamide or vice versa, or 177Lu-PSMA-617, a prostate-specific antigen (PSMA)-targeted radioligand therapy. This analysis found that treatment with 177Lu-PSMA-617 prolonged radiographic progression-free
Maxone73
in
Advanced Prostate Cancer
5 months ago
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radiation treatment delayed
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
thansen535
in
Advanced Prostate Cancer
5 months ago
radiation treatment delayed
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
thansen535
in
Advanced Prostate Cancer
5 months ago
Advice - Surgery or Radiation?
Hi all, apologies for the long post, hoping to give as much info as possible. Background: Diagnosis: Unfavorable int-risk prostate cancer (T2a, Gleason 4+3, PSA 5.2) (I spoke to a surgeon today who said it was T3a so now I am confused) Age: 59 PSA 5.2 (H) 01/31/2024 PSA 4.4 (H) 11/06/2023 PSA
Hi all, apologies for the long post, hoping to give as much info as possible. Background: Diagnosis: Unfavorable int-risk prostate cancer (T2a, Gleason 4+3, PSA 5.2) (I spoke to a surgeon today who said it was T3a so now I am confused) Age: 59 PSA 5.2 (H) 01/31/2024 PSA 4.4 (H) 11/06/2023 PSA
Blue1320
in
Prostate Cancer Network
5 months ago
Blood
Well after tests on low red cells turned out to be a polyp which was removed and a large tumour in the bowel which was positive I am 3 weeks into recovery from bowel resection just waiting for preventative chemotherapy all is good first post in a while due to surgery etc
Well after tests on low red cells turned out to be a polyp which was removed and a large tumour in the bowel which was positive I am 3 weeks into recovery from bowel resection just waiting for preventative chemotherapy all is good first post in a while due to surgery etc
ChillyAsh34
in
MPN Voice
5 months ago
Clinical trial news
Has anyone been 'volunteered ' for this new trial from Astra Zanaca? Saruparib (AZD5305) vs Placebo in Men with Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents - EvoPAR-PR01 This is looking at whether adding a new drug on top of taking an Androgen Receptor
Has anyone been 'volunteered ' for this new trial from Astra Zanaca? Saruparib (AZD5305) vs Placebo in Men with Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents - EvoPAR-PR01 This is looking at whether adding a new drug on top of taking an Androgen Receptor
Max24
in
Advanced Prostate Cancer
5 months ago
CRISPR news: protein arginine methyltransferase 7 as a novel essential gene in prostate cancer metastasis (in vitro)
Now, tell me how to deal with it! https://pubmed.ncbi.nlm.nih.gov/38432581/
Now, tell me how to deal with it! https://pubmed.ncbi.nlm.nih.gov/38432581/
Maxone73
in
Advanced Prostate Cancer
5 months ago
CAR-T: new phase 1 trial will soon start to enroll
P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC) Promising preclinical tests, but it's a phase 1 trial https://clinicaltrials.gov/study/NCT04249947
P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC) Promising preclinical tests, but it's a phase 1 trial https://clinicaltrials.gov/study/NCT04249947
Maxone73
in
Advanced Prostate Cancer
5 months ago
Fatigue
I was diagnosed WITH MBC 5 years ago after being
cancer
free for 20 years from my
breast
cancer
diagnosis. My last CT scan a month ago shows still no spread, apparently I have the most least aggressive type of
breast
cancer
.
I was diagnosed WITH MBC 5 years ago after being
cancer
free for 20 years from my
breast
cancer
diagnosis. My last CT scan a month ago shows still no spread, apparently I have the most least aggressive type of
breast
cancer
.
Alnmouth
in
SHARE Metastatic Breast Cancer
1 year ago
Surgery or radiation, looking for some advices
Hi everyone, I’m looking for some advices for my father. He was recently diagnosed with prostate cancer. He probably already had it for a long time. Quite high PSA (way over 20), and spread to multiple lymph nodes. The surgeon said surgery is still doable, followed by radiation. Radiation oncologist
Hi everyone, I’m looking for some advices for my father. He was recently diagnosed with prostate cancer. He probably already had it for a long time. Quite high PSA (way over 20), and spread to multiple lymph nodes. The surgeon said surgery is still doable, followed by radiation. Radiation oncologist
Healing1826
in
Advanced Prostate Cancer
5 months ago
Free Download - Prostate Cancer Comic Book about stage IV
Our wonderful community member James Burns has created a full-length comic book about his experiences with stage IV prostate cancer. Get your free download here: https://malecare.org/prostate-cancer-comic-book
Our wonderful community member James Burns has created a full-length comic book about his experiences with stage IV prostate cancer. Get your free download here: https://malecare.org/prostate-cancer-comic-book
Darryl
Partner
in
Advanced Prostate Cancer
5 months ago
GRATEFUL
Went to appointment with Radiation Oncologist at Emory St. Joseph's Winship Cancer Center - Dr. Bruce Hershatter. Good guy, no BS, straight shooter. He actually drew it out on a sheet of paper (front & back, back was worse) for me and talked me and my friend through the options (1) and pretty much
Went to appointment with Radiation Oncologist at Emory St. Joseph's Winship Cancer Center - Dr. Bruce Hershatter. Good guy, no BS, straight shooter. He actually drew it out on a sheet of paper (front & back, back was worse) for me and talked me and my friend through the options (1) and pretty much
BCPC
in
Advanced Prostate Cancer
3 months ago
A promising adjuvant for immunotherapy in multiple cancers: PVP-037
Hopefully it will help with prostate as well! https://www.drugtargetreview.com/news/151463/discovery-of-a-promising-agonist-adjuvant/
Hopefully it will help with prostate as well! https://www.drugtargetreview.com/news/151463/discovery-of-a-promising-agonist-adjuvant/
Maxone73
in
Advanced Prostate Cancer
3 months ago
Xofigo anyone?
So my PSA is rising after Chemo, Lupron and NUBEQA (Darolutamide). It rose from 0.04 in June 2023 to 0.84 at the end on April 2024 with latest time of doubling about 5 weeks, 2.3 years after diagnosis. I don't have organ on lymph node metastasis yet. My oncologists team suggests Xofigo/Ra-223 as a next
So my PSA is rising after Chemo, Lupron and NUBEQA (Darolutamide). It rose from 0.04 in June 2023 to 0.84 at the end on April 2024 with latest time of doubling about 5 weeks, 2.3 years after diagnosis. I don't have organ on lymph node metastasis yet. My oncologists team suggests Xofigo/Ra-223 as a next
Oldie68
in
Advanced Prostate Cancer
5 months ago
List of drugs by their metastatic prostate cancer cancer fighting properties
I asked ChatGPT to put the following drugs in order of their metastatic prostate cancer cancer fighting properties: Metformin, statins, mebendazole, vitamin C, doxycline, Silymarin and Esomeprazole (Nexium). Here is the answer from ChatGPT: Determining the order of these drugs based on their potential
I asked ChatGPT to put the following drugs in order of their metastatic prostate cancer cancer fighting properties: Metformin, statins, mebendazole, vitamin C, doxycline, Silymarin and Esomeprazole (Nexium). Here is the answer from ChatGPT: Determining the order of these drugs based on their potential
Seasid
in
Advanced Prostate Cancer
3 months ago
Unusual case
Short summary. 79 years old. Surgery 12 years ago on G4+3. Recurrence 3 years later. IMRT and second recurrence 3 years later. No ADT. PSADT 1.5 years and now it's 2.3. Two PSMA scans. First showed nothing. Second showed ill defined area in prostate bed that might be positive. Never had ADT.
Short summary. 79 years old. Surgery 12 years ago on G4+3. Recurrence 3 years later. IMRT and second recurrence 3 years later. No ADT. PSADT 1.5 years and now it's 2.3. Two PSMA scans. First showed nothing. Second showed ill defined area in prostate bed that might be positive. Never had ADT.
npac
in
Advanced Prostate Cancer
3 months ago
PSA down with Enzalutamide 160 and Wysolone 5 mg
My father has had a relapse of long controlled PSA in 2022 and his PSA levels went upto 10.58; abieraterone didn't work ; he was also put on Docetaxal, he could tolerate one dose of it only and was stopped on this...he is on Enzalutamide 160 along with Wysolone 5 mg for the last 4 months...with his
My father has had a relapse of long controlled PSA in 2022 and his PSA levels went upto 10.58; abieraterone didn't work ; he was also put on Docetaxal, he could tolerate one dose of it only and was stopped on this...he is on Enzalutamide 160 along with Wysolone 5 mg for the last 4 months...with his
Ij2023
in
Advanced Prostate Cancer
5 months ago
Prolia shots
After 4+ years of Actonel is Prolia a good choice for continued treatment of osteoporosis? I will be asking my rheumatologist the same question next time I see her. I am due for another bone scan so she will most likely want to see that first but based on the first 2 tests I am going downhill bone-wise
After 4+ years of Actonel is Prolia a good choice for continued treatment of osteoporosis? I will be asking my rheumatologist the same question next time I see her. I am due for another bone scan so she will most likely want to see that first but based on the first 2 tests I am going downhill bone-wise
Alebeau
in
PMRGCAuk
5 months ago
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