Phase 1 trial shows promising results for fractionated dose of 225Ac-J591 in PCa treatment

[Maxone73]

The fractionated dosing achieved promising results with 95% of patients experiencing any PSA decline and 71% achieving a PSA50 response. In contrast, the multiple cycles cohort saw 72% of patients with any PSA decline and 28% achieving a PSA50 response...fractionate good!

urotoday.com/conference-hig...

[Islandboy2021]

So what is the take away here. It’s a higher dose every 8 weeks. I am not a research scientist.

[Maxone73 in reply to Islandboy2021]

Smaller dose more often produced way better results than big doses more sparse as for pluvicto from what I understood

[TeleGuy]

Would someone please explain to me the use of the term "fractionated" in this case? From my reading, the trial gave a single dose of 225AC-J591, so how can they say that it was fractionated?

[Maxone73 in reply to TeleGuy]

They talk about a complete dose every 6 weeks or a smaller dose every 2 or 3 weeks, I don it remember exactly. But at the beginning they talk about a single dose because they start summarizing the finding from phase 1a that was dose escalation only.

[TeleGuy in reply to Maxone73]

Thanks. I'll look at it again.