I asked ChatGPT to put the following drugs in order of their metastatic prostate cancer cancer fighting properties:
Metformin, statins, mebendazole, vitamin C, doxycline, Silymarin and Esomeprazole (Nexium).
Here is the answer from ChatGPT:
Determining the order of these drugs based on their potential benefit in fighting metastatic prostate cancer involves considering the available evidence, mechanisms of action, and the extent of clinical research. Here's an attempt to rank them, keeping in mind that this is not definitive and that individual responses to treatments can vary:
### 1. **Metformin**
- **Evidence**: Metformin, a diabetes drug, has shown significant promise in various cancer studies, including prostate cancer. Its potential anti-cancer effects are attributed to its ability to lower insulin levels and directly inhibit cancer cell proliferation through the AMPK/mTOR pathway.
- **Research**: There are numerous preclinical studies and ongoing clinical trials investigating metformin’s role in cancer treatment, including prostate cancer.
### 2. **Statins**
- **Evidence**: Statins, used to lower cholesterol, have shown potential anti-cancer properties through mechanisms such as inhibiting cancer cell proliferation and inducing apoptosis. Some observational studies suggest a reduced risk of advanced prostate cancer among statin users.
- **Research**: Statins have been the subject of many studies regarding cancer prevention and treatment, with some evidence indicating potential benefits for prostate cancer patients.
### 3. **Mebendazole**
- **Evidence**: Mebendazole has shown anti-cancer properties in preclinical studies, including effects on inhibiting tumor growth and metastasis in prostate cancer. Its ability to disrupt microtubule formation in cancer cells is a key mechanism.
- **Research**: While promising, clinical evidence is limited, and more research is needed to establish its efficacy in human patients.
### 4. **Vitamin C (High-Dose)**
- **Evidence**: High-dose intravenous vitamin C has shown some potential in enhancing the effects of certain chemotherapy drugs and inducing oxidative stress selectively in cancer cells.
- **Research**: There are ongoing studies and some promising preclinical results, but evidence in metastatic prostate cancer is not yet conclusive.
### 5. **Doxycycline**
- **Evidence**: Doxycycline, an antibiotic, has shown some anti-cancer properties, including inhibition of matrix metalloproteinases and induction of cancer cell apoptosis. There is some interest in its use in combination with other drugs.
- **Research**: The evidence is mainly preclinical, and more clinical trials are necessary to validate its benefits in metastatic prostate cancer.
### 6. **Silymarin**
- **Evidence**: Silymarin has antioxidant and anti-inflammatory properties, with some studies suggesting it can induce apoptosis in cancer cells. However, specific evidence for its use in metastatic prostate cancer is limited.
- **Research**: Most studies focus on its general health benefits and liver protection, with limited direct evidence for its efficacy in prostate cancer treatment.
### 7. **Nexium (Esomeprazole)**
- **Evidence**: Nexium, a proton pump inhibitor, has some emerging evidence suggesting it might influence cancer cell behavior and tumor microenvironment, but this is very preliminary.
- **Research**: Research in cancer therapy is limited, and its primary use remains in treating acid-related gastrointestinal conditions.
### Summary
1. **Metformin**
2. **Statins**
3. **Mebendazole**
4. **Vitamin C (High-Dose)**
5. **Doxycycline**
6. **Silymarin**
7. **Nexium**
It's important to note that the use of these drugs for metastatic prostate cancer should be discussed with a healthcare provider, as the evidence varies and the best treatment approach depends on individual patient factors and the latest clinical research.
Please comment if you have any opinion about this.
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I asked for the best metastatic prostate cancer cancer fighting dose recommendation for the above drugs:
Here is the answer:
Determining the best doses for the drugs listed in the context of metastatic prostate cancer treatment should be done in consultation with healthcare professionals and based on the latest clinical guidelines and research. Here are some general recommendations based on available evidence, but these should not replace professional medical advice:
- **Notes**: This dose is typically used for diabetes management but has been used in various cancer trials. Monitoring for gastrointestinal side effects and lactic acidosis is important. (I would add: definitely monitor vitamin B12 levels.)
- **Notes**: This dose is extrapolated from its use in preclinical studies and anecdotal reports. Long-term safety and efficacy data in cancer patients are limited.
### 4. **Vitamin C (High-Dose)**
- **Typical Dose**: 10-100 grams intravenously, 2-3 times per week.
- **Notes**: High-dose intravenous vitamin C is often administered in a clinical setting under medical supervision to monitor for side effects and ensure proper administration.
### 5. **Doxycycline**
- **Typical Dose**: 100 mg twice daily (oral).
- **Notes**: Commonly used in combination with other therapies. Long-term use requires monitoring for side effects like photosensitivity and gastrointestinal disturbances.
### 6. **Silymarin**
- **Typical Dose**: 420-600 mg daily (oral).
- **Notes**: Doses used for liver protection and general health benefits. Specific anti-cancer dosing needs more research.
### 7. **Nexium (Esomeprazole)**
- **Typical Dose**: 20-40 mg daily (oral).
- **Notes**: Primarily used for managing gastrointestinal symptoms. Any potential anti-cancer effects are still under investigation and not well-established.
### Important Considerations
1. **Consultation with Healthcare Providers**: Always discuss with oncologists or other healthcare providers before starting any new treatment. They can provide personalized recommendations based on your specific medical history and current treatment plan.
2. **Monitoring and Side Effects**: Regular monitoring for side effects and interactions with other medications is crucial. Adjustments to dosing may be necessary based on tolerability and response.
3. **Clinical Trials**: Participating in clinical trials can provide access to new treatments and contribute to the body of research on these drugs' efficacy and safety in metastatic prostate cancer.
These recommendations provide a general starting point, but personalized treatment plans and dosages should always be determined by healthcare professionals.
Nexium (esomeprazole) is indeed a proton pump inhibitor (PPI). Here are some key points about it:
1. **Purpose**: Nexium reduces stomach acid production, which can help treat conditions like gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and erosive esophagitis. It’s also used to prevent stomach ulcers, especially in people taking NSAIDs (nonsteroidal anti-inflammatory drugs).
2. **Duration of Use**: While some over-the-counter versions of Nexium are intended for short-term use (typically 14 days), the duration can vary based on the condition being treated. For chronic conditions, a healthcare provider might prescribe it for longer periods.
3. **Mechanism of Action**: Nexium works by blocking the proton pump in the stomach lining, which significantly reduces the production of stomach acid.
4. **Potential Side Effects**: Common side effects include headache, diarrhea, nausea, and stomach pain. Long-term use can lead to more serious effects like vitamin B12 deficiency, magnesium deficiency, and increased risk of bone fractures.
5. **Considerations for Use**: It's important to follow your healthcare provider's guidance regarding the duration and dosage. Stopping PPIs suddenly can lead to rebound acid production.
If you have any specific concerns or need detailed information about its interaction with other medications or conditions, let me know!
Balancing Metformin use and controlling Homocysteine levels can indeed be tricky. Here are a few suggestions that might help you achieve that balance:
1. **Regular Monitoring**: Keep regular checks on your Homocysteine levels and adjust your supplementation as needed.
2. **Dietary Adjustments**: Consider dietary changes that can help reduce Homocysteine levels, such as increasing intake of B vitamins (B6, B12, and folate) through foods like leafy greens, beans, and fortified cereals.
3. **Consult Healthcare Provider**: Regularly discuss your treatment plan with your healthcare provider. They might adjust your Metformin dosage or recommend other medications that don’t affect Homocysteine levels as much.
4. **Balanced Supplementation**: Ensure your Homocysteine-lowering supplements are balanced and not overly reliant on phosphorylation processes. This might involve a mix of vitamins and other compounds.
5. **Lifestyle Factors**: Regular exercise, quitting smoking, and reducing alcohol intake can also help manage Homocysteine levels.
Would you like more detailed information on any of these suggestions or any other related topic?
I am adding this for people who are considering the use of berberine instead of Metformin in order to avoid vitamin B12 deficiency.:
Berberine is a natural compound that has shown some similar benefits to Metformin, including improving blood sugar control and potentially having anti-cancer properties. However, there are important considerations:
1. **Effectiveness**: While berberine can help with blood sugar control, its efficacy compared to Metformin can vary from person to person. Metformin is a well-studied medication with a proven track record, whereas the clinical evidence for berberine, although promising, is less extensive.
2. **Safety and Interactions**: Berberine is generally considered safe, but it can interact with other medications and may have side effects. It's important to discuss this with your healthcare provider to ensure it won't interfere with your current treatment regimen.
3. **B-12 Deficiency**: Berberine is less likely to cause B-12 deficiency compared to Metformin. However, it is not entirely free of potential side effects, and its long-term impact on B-12 levels hasn't been as extensively studied as Metformin's.
4. **Prostate Cancer**: Berberine has some reported anticancer properties, but its effects on prostate cancer specifically are not as well-documented as Metformin's. It's crucial to consider the overall impact on your cancer treatment.
Given these points, switching to berberine could potentially help with avoiding B-12 deficiency, but it should be done under the guidance of your healthcare provider. They can help monitor your blood sugar levels and overall health to ensure the switch is beneficial and safe for you.
Interesting List... I'm glad the conversation in Oncology is beginning to include the potential introduction and use of "off-label" medicines with SOC 🙏 ChatpGPT is cool 😎
Start using ChatGPT in your whole life not just with off label drugs. I am successfully translating ChatGPT answers into Hungarian in order to send it to my sisters. They don't speak English. I asked questions about banking etc.
This reminds me of the phony Hungarian dictionary sketch in Monty Python ( possibly available on Youtube?). Have you been able to get the results checked?
No, but I checked with the ChatGPT what I was told and that is also a big going forward. I am behind watching Monty python's as you see I have other forms of entertainment here.
from that conclusion “Studies have reported conflicting results regarding the association of metformin use and the risk of PCa incidence and survival outcome. ”
in other words until there is a good study correctly done, showing efficacy, adding metformin is as random as adding a random vitamin especially for stage 4 patients. Which is probably why oncologists and urologists do not say, as you leave the office, “dont forget to take your metformin”.
chat gpt is pretty good if you already kind of know enough of the answer to vet it, because it can just hallucinate an order an arrangement of a list but with great confidence.
We agree that we should not trust ChatGPT but myself I would not trust to anyone fully whit our diagnosis. I stopped Metformin and statins after I was diagnosed with dry eyes, blepharitis and corneal edema just for short time and my PSA rocketed up. I started again an now the PSA stabilised. I am still watching carefully what is happening.
The reason I stopped Metformin after my corneal edema diagnosis was because I have also sleep Apnoea and I was afraid that as a result I had lactic acidosis as a side effects of the Metformin use. Lactic acidosis could produce at least temporarily corneal edema therefore it can result in pseudo Fux disease as it was observed by one marathon runner. After clearing the lactic acid the corneal edema disappeared.
Plus I don't like Metformin because my vitamin B12 levels are very low and I don't want to supplement the vitamin B12 because it is not recommended if you have a prostate cancer.
My understanding was that if you have an aggressive prostate cancer Metformin could help you and that is important. If you don't have that form of aggressive prostate cancer than I wouldn't care if Metformin is not helping me.
Therefore again: Metformin is effective if you have an aggressive form of prostate cancer and that is the most important what I wish to avoid.
Thank you for posting. I take 4 of the top 5 (so not the Vitamin C high dose) as these 4 are prescribed by the care oncology clinic (COC). I have zero idea on if any of them actually make a difference but they are all in the mix. I am also on quarterly Lupron injections (Prostap and daily Enzalutamide 160mg as my standard of care.
Basically with the care oncology clinic protocol you take Metformin 500mg X2 daily and Atorvastatin 40mg X1 daily. You then do 4 weeks of Mebendazole 100mg tablets X1 daily before switching to 4 weeks of Doxycycline 100mg capsules X1 daily, then back to 4 weeks on Mebendazole etc. The only one I do not seem to tolerate is the Doxycycline which has a photosensitivity issue when it is sunny for me at least.
The Care Oncology Clinic needs your blood results before prescribing and I would say to anyone who is looking at these to discuss with your medical oncology team.
Thanks for the information. I tolerate everything well except Metformin. I would be happy to stop but when I stopped because of my dry eyes, blepharitis and corneal edema diagnosis my PSA rocketed up and I wasn't sure if it is because of the effects of the drug on the PSA or also on the cancer.
I have to take Metformin because it is beneficial for the cancer fight and also because it reducing the possibility to bread out resistant strains of the bacterias as a result of the use of the doxycycline.
One more think. At the earlier stages of my prostate cancer treatment I was taking only rosuvastatin 40 mg per day plus a baby aspirin. I didn't take anything else. After about four years into my prostate cancer treatment after my fdg pet scan I decided to stop a baby aspirin. The reason was that I was getting older and I didn't want to fall and possibly have bleeding as a result of the fall etc. Taking aspirin was always dangerous because of the bleeding possibility.
I apologize for that. I thought that it is a common knowledge on this site that everyone starts with the ADT at least and ones you are deeply castrated than you add early docetaxel chemotherapy 6 cycles at least for de novo metastatic prostate cancer treatment.
Good point. You could also download the ChatGPT app and try it out for yourself. I am very impressed with the artificial intelligence. I could also add melatonin plus Resveratrol but it cost lots of money.
- **Standard of Care Therapies**: Well-established with robust evidence for improving survival and quality of life, but come with significant side effects.
- **Alternative Therapies**: Show potential in preliminary studies, but lack extensive clinical evidence. They are generally well-tolerated but should not replace standard therapies without further research and clinical validation.
### Clinical Guidance
It's crucial for patients to discuss any potential use of these alternative therapies with their healthcare providers to ensure safety and compatibility with their existing treatment plans.
I would definitely not recommend off label drugs instead of standard of care drugs. I am still alive more than 6 years after my initial de novo polimetastatic prostate cancer with distant metastasis because of early docetaxel chemotherapy plus degarelix ADT, but I believe that the early use (after my early docetaxel chemotherapy) of rosuvastatin plus aspirin (I don't like to much to talk about Aspirin because some people can have bleeding even after the first Aspirin and I know that fist hand from the gastroenterologist from 40 years ago),
I believe that maybe lowering cholesterol stopped the cancer hoarding cholesterol and deprived it from fuel to use later ones it mutates (switched) to produce own testosterone from that hoarded cholesterol and now I have no visible metastases on any scan yet.
Therefore I am not talking here to replace standard of care drugs but rather to add at least statins. I decided to use crestor (rosuvastatin) because it was recommended by my GP long time ago being the most effective statin and I didn't have known side effects only maybe dry eyes what is just a hypothesis.
If you have an aggressive cancer you may also benefit from Metformin. Plus Metformin and doxycline could have effects on the cancer stem cells while maybe chemotherapy and radiation don't have effects on prostate cancer stem cells. I am not a doctor but if I can reduce the likelihood of the development of further metastasis with proven drugs which are relatively safe and in common use than why not try especially if as result of the standard of care drugs we are 30 % likely to develop heart disease.
I just recently added mebendazole and most recently after extensive research Silymarin which maybe act as natural PARP inhibitor according to some Indian study which is not pear reviewed yet.
Lot of people I know are using Silymarin for liver health and if it is produced exclusively from the seeds of the plant and don't contain phytoestrogens than why not try it?
My father was using Silymarin. I don't drink alcohol therefore I never used it and my last liver fibroscan result was 3.7. but now I started to consider Silymarin after my liver ultrasound did show some changes on my liver.
The best use of PARP inhibitors would be with chemotherapy and radiation but when I asked for that they refused. Therefore now you could just use Silymarin for liver health at least with radiation. With the SBRT of my prostate we successfully bread out to the radiation most resistant strains. I am not impressed but unfortunately radiation can fail therefore why not try something what could have natural PARP inhibitor properties and kill the cancer?
Excellent point. However, cheap alternative OTC off-label meds will never be subjected to the type of FDA trials required for new Rx drug approval; it simply won't happen.
And they are different. New Rx drugs are engineered to stop raging cancer in its tracks. Damn the side effects, at least to a far point. If the drug fails after 2-3 years, it is still a success.
Repurposed OTC drugs and supplements, to the extent they work at all, work much more slowly, over years sometimes. And no one knows for certain due to those and other limitations.
So we are, and always will be, comparing apples to oranges when we discuss this subject.
But I think your point is very valid; it's just that I don't think the two can be directly compared.
1) Several years ago, I was communicating with a researcher who was experimenting with Silymarin and prostate cancer. At that time, he found that the Silymarin molecules were "too large to be effective." However, since then, the Life Extension people. and others, have come up with a product that is lipophilic and contains A & B forms of milk thistle. This relatively new formula seems to have solved the researcher's problems with absorbability.
2) Several years ago I discovered that Metformin raises Homocysteine levels. My levels of H have gone beyond the normal range. In order to bring the levels down, I have been taking Homocysteine Supreme that contains a formula designed to do this. I am aware of the problem with phosphorylation which, when over done, may increase PCa activity. The trick is to achieve a balance between using Metformin and controlling Homocysteine.
Balancing Metformin use and controlling Homocysteine levels can indeed be tricky. Here are a few suggestions that might help you achieve that balance:
1. **Regular Monitoring**: Keep regular checks on your Homocysteine levels and adjust your supplementation as needed.
2. **Dietary Adjustments**: Consider dietary changes that can help reduce Homocysteine levels, such as increasing intake of B vitamins (B6, B12, and folate) through foods like leafy greens, beans, and fortified cereals.
3. **Consult Healthcare Provider**: Regularly discuss your treatment plan with your healthcare provider. They might adjust your Metformin dosage or recommend other medications that don’t affect Homocysteine levels as much.
4. **Balanced Supplementation**: Ensure your Homocysteine-lowering supplements are balanced and not overly reliant on phosphorylation processes. This might involve a mix of vitamins and other compounds.
5. **Lifestyle Factors**: Regular exercise, quitting smoking, and reducing alcohol intake can also help manage Homocysteine levels.
Would you like more detailed information on any of these suggestions or any other related topic?
Intersting topic, but I really hope you are still seeing an Oncologist who has prescribed the stanard therapy drugs such as Zytiga and or Enzalutimide(xtandi). You should not depend on anything that Dr Google has posted.
web.archive.org/web/2024041... archive shows April 16, 2024 this page. Which has apparently there is an open dataset available. According to this page last scrape done by archive.
"Search our AI curated corpus of 2,044 supplements, 2,866 drugs and 59,096 interactions and explore the related research. Our work is not influenced by third parties. Supp.AI is a free service of the non-profit Allen Institute for AI."
"Data & API
Our dataset is public and available for download here. (<--- outbound link on archive below- goes to a 502 error, however the archive.org link has the dataset) An API is also available here for automated data access."
Once you sign off on the boilerplate you get redirected to the stored page. I didn't download it, so see if that works.
FYI anyone looking for alternative information that was scrubbed, removed, censored, covered up- there are ton's of old web sites and pages available on archive.org. Great research resource for those are not aware of such.
Good point. I am really not a doctor only using the AI to help me with my options and as we all know we can't fully rely on AI to make a decision for us. Actually we can't unfortunately rely on anybody else only on ourselves.
I listed the above medications mainly because I am using them or because I am familiar with them or because I wish to try them.
i think that asking the AI is a good first step.
As an example:
I heard about natural PARP inhibitors on this site and become interested. My next step was a Google search and I digged up an interesting research paper from India which states that Silymarin is the most effective PARP inhibitor better than any other PARP inhibitor currently available.
The Indian study was not peer reviewed but it looked with potential because Silymarin is used for centuries and it is considered safe.
After that first step I was looking for information about silymarin and digged up that for us cancer patients only the Silymarin produced from the seeds of the plant is safe because it doesn't contain phytoestrogens.
I found a Milk thistle seeds product from NZ which contains Silymarin from minimum 45 g dry seeds per capsule and it is clearly stated on the bottle. That is sold for liver health therefore maybe sending this product to the laboratory for further analysis would be necessary in order to avoid estrogenic effects associated with Silymarin which is not sourced exclusively from seeds of the plant.
As you see it is like a detective work. Very slow and time consuming. You should spend lots of time.
Even if you ask the AI to list all the products you should go a level above and analysis it for failure modes and effects
You should really have a medical degree in order to do that work or at least you should closely work together with a medical oncologist or pharmacist.
Always do your own research and consult with your oncologist before doing anything. I came to the point that only trust myself. Not because I amore educated but because I can assure that all the steps are done to my satisfaction and I do have a terminal illness therefore I should fil comfortable with my own decisions.
Phytochemicals have been studied for their potential to target prostate cancer stem cells (CSCs), which are believed to play a role in cancer initiation, progression, metastasis, and recurrence. Some notable phytochemicals that have shown promise in targeting prostate cancer stem cells include:
1. **Curcumin**: Found in turmeric, curcumin has anti-inflammatory and anti-cancer properties. It can inhibit prostate CSC proliferation and induce apoptosis.
2. **Resveratrol**: Present in grapes and red wine, resveratrol has been shown to inhibit the growth and self-renewal of prostate CSCs by affecting various signaling pathways.
3. **Epigallocatechin gallate (EGCG)**: A major component of green tea, EGCG has been demonstrated to reduce prostate CSC viability and hinder their ability to form tumors.
4. **Sulforaphane**: Found in cruciferous vegetables like broccoli, sulforaphane targets prostate CSCs and has been shown to inhibit their self-renewal and tumorigenic potential.
5. **Lycopene**: Abundant in tomatoes, lycopene has been associated with a reduced risk of prostate cancer and may interfere with CSC signaling pathways.
6. **Genistein**: An isoflavone found in soy products, genistein can inhibit the proliferation of prostate CSCs and promote their differentiation.
These phytochemicals can exert their effects through various mechanisms, such as modulating signaling pathways (e.g., Wnt/β-catenin, Notch, Hedgehog), inducing apoptosis, inhibiting angiogenesis, and reducing inflammation. While these compounds show promise in preclinical studies, further clinical research is needed to establish their efficacy and safety in targeting prostate cancer stem cells in humans.
Considering your interest in minimizing phytoestrogen intake, it's worth noting that compounds like genistein are phytoestrogens. Balancing the potential benefits and risks of such compounds is essential in the context of your overall treatment plan.
Do you have visible bone metastasis on scans? Where do you have them? It is also ok if the bone Mets are not visible anymore on the scan. Could you showers them with warm water? chatgpt.com/share/d6afd843-...
Hyperthermia in cancer treatment does not act as a vaccination. Hyperthermia involves heating body tissues to damage and kill cancer cells or to make them more susceptible to other treatments like radiation therapy and chemotherapy. It works by increasing the temperature of the tumor cells, which can enhance the effects of these treatments and potentially improve their outcomes.
In contrast, a vaccination works by stimulating the body's immune system to recognize and fight specific pathogens or disease-causing agents. While hyperthermia can sometimes stimulate an immune response against cancer cells, it does not create the same lasting immunity that a vaccine does.
However, some research is exploring the use of hyperthermia in combination with immunotherapies to boost the immune system's response to cancer, potentially leading to more effective treatments.
Yes, chemotherapy and radiation therapy can release antigens and stimulate the immune system against cancer. This process is known as immunogenic cell death. When cancer cells are killed by these treatments, they can release tumor antigens and other molecules that signal the immune system to recognize and attack the remaining cancer cells.
Here’s how it works:
1. **Antigen Release**: As cancer cells die due to chemotherapy or radiation, they release antigens specific to the tumor.
2. **Immune Activation**: These antigens are taken up by antigen-presenting cells, like dendritic cells, which then present them to T-cells.
3. **T-cell Response**: The T-cells become activated and can target and destroy remaining cancer cells that express the same antigens.
This process can enhance the body's natural immune response to cancer, potentially leading to better outcomes. Combining traditional therapies with immunotherapies is an area of active research, aiming to improve the effectiveness of cancer treatments by leveraging this immune activation.
Yes, hyperthermia can affect cancer cells in a way that promotes the release of antigens and stimulates an immune response. The heat stress induced by hyperthermia can cause cancer cells to undergo a form of cell death that is more immunogenic. Here’s how this process works:
1. **Heat Stress**: Hyperthermia exposes cancer cells to elevated temperatures, causing them to become stressed and eventually die.
2. **Antigen Release**: As cancer cells die from heat stress, they release tumor antigens into the surrounding tissue.
3. **Immune System Activation**: These antigens can be taken up by dendritic cells and other antigen-presenting cells, which then migrate to lymph nodes and present the antigens to T-cells.
4. **T-cell Response**: The activated T-cells can then seek out and destroy other cancer cells that express the same antigens.
In addition to antigen release, hyperthermia can increase the permeability of the tumor vasculature, enhance the infiltration of immune cells into the tumor, and improve the effectiveness of other treatments such as radiation and chemotherapy. This makes hyperthermia a promising adjuvant therapy that can potentially boost the overall immune response against cancer.
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