Clinical trial news

[Max24]

Has anyone been 'volunteered ' for this new trial from Astra Zanaca?

Saruparib (AZD5305) vs Placebo in Men with Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents - EvoPAR-PR01

This is looking at whether adding a new drug on top of taking an Androgen Receptor Target Therapy (ARAT; such as abiraterone, darolutamide, enzalutamide) results in better outcomes (getting the cancer until control longer) than just taking an ARAT alone.

As this is a North American trial, would love to hear from others...

[j-o-h-n]

Sgt. says to his platoon.......... I want 4 volunteers...... you, you, you and you.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Seasid in reply to j-o-h-n]

I am a soldier

[j-o-h-n in reply to Seasid]

I guess Sarge meant you...

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 01/04/2025 11:46 AM EST

[Seasid in reply to j-o-h-n]

They also wanted to regrut me as a "volonter" to a same Astra zeneca parp inhibitor trial but for toxicity study. The inclusion criteria asked for a visible metastasis on a scan and my MO sent me to get a PSMA pet scan. The PSMA pet scan came out as no visible metastasis therefore I am not eligible but my MO said that because I am "vololontering" to a toxicity study first in human phase I clinical trial he will talk to Astra zeneca to take me because it is not really relevant if you have or not a visible metastasis on a scan. Otherwise I was de Novo polymetastatic prostate cancer at the diagnosis. I dogged a bullet and I am still having an easy ride on bicalutamide plus ADT. Parp inhibitor are usually very toxic and I would only use them when I run out of other options because it looks to me (I am not a doctor) that you could develop resistance therefore it is better to save these bulets for the end. I was diagnosed in April 2018 and started ADT in June 2018. It is more than 6.5 years ago.

[j-o-h-n in reply to Seasid]

Platoon Sargent's command was "Men take that hill".

Platoon Sargent's command now "Men take that pill".

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 01/04/2025 2:10 PM EST

[God_Loves_Me]

In absence of mutation can we add with xtandi ?

[Maxone73]

what I have found online (October last year) was very good, and I hope so as I have an atm mutation!