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Ravid Straussman & the Tumor Biome
We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven
cancer
types, including
breast
, lung, ovary, pancreas, melanoma, bone, and brain tumors {but not PCa}.
We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven
cancer
types, including
breast
, lung, ovary, pancreas, melanoma, bone, and brain tumors {but not PCa}.
pca2004
in
Fight Prostate Cancer
10 months ago
Recurrence after prostatectomy
I have a relative who had surgery 6.5 years ago. Pathology was very favorable, 3+3+tertiary 4 i.e. less than 5%, no pos margins, no ECE, no nodes. He remained undetectable for 6.5 years, but now is .07 verified. What would SOC be for him? Prostate bed or wide radiation, length of ADT, just Lupron or
I have a relative who had surgery 6.5 years ago. Pathology was very favorable, 3+3+tertiary 4 i.e. less than 5%, no pos margins, no ECE, no nodes. He remained undetectable for 6.5 years, but now is .07 verified. What would SOC be for him? Prostate bed or wide radiation, length of ADT, just Lupron or
Fred312
in
Advanced Prostate Cancer
5 months ago
High volume, advanced metastatic prostate cancer
Hello. I am looking for guidance. My dad (now 81) was diagnosed with metastatic prostate cancer at the initial point of diagnosis in the ER on 10/25/2022. It had spread to 8 bones and was all over his spine, hip, base of skull, etc, but also as far as the base of the skull, and shoulder. His PSA was
Hello. I am looking for guidance. My dad (now 81) was diagnosed with metastatic prostate cancer at the initial point of diagnosis in the ER on 10/25/2022. It had spread to 8 bones and was all over his spine, hip, base of skull, etc, but also as far as the base of the skull, and shoulder. His PSA was
lgutman
in
Advanced Prostate Cancer
2 months ago
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BROQ/Prostaphane
Last week I had my 3 monthly PSA check and was happy and surprised to see that it had remained unchanged at 0.07. It had previously been creeping up and I am not currently on any treatement since my Cyberknife to a lymph node in December 21 together with 6 months of bicalutamide. I take a large variety
Last week I had my 3 monthly PSA check and was happy and surprised to see that it had remained unchanged at 0.07. It had previously been creeping up and I am not currently on any treatement since my Cyberknife to a lymph node in December 21 together with 6 months of bicalutamide. I take a large variety
GreenStreet
in
Fight Prostate Cancer
5 months ago
bicalutamide no longer as effective?
After more than two years of bicalutamide monotherapy and repeated PSA<0.1 I just received a 0.6. Before the bicalutamide my PSMA scan showed activity in only the seminal vesicle region. PSA was 2.5 at that time. Lupron had ceased being effective. Bicalutamide had a terrific response. I don’t think PSMA
After more than two years of bicalutamide monotherapy and repeated PSA<0.1 I just received a 0.6. Before the bicalutamide my PSMA scan showed activity in only the seminal vesicle region. PSA was 2.5 at that time. Lupron had ceased being effective. Bicalutamide had a terrific response. I don’t think PSMA
kreg001
in
Advanced Prostate Cancer
5 months ago
Elevated PSA 8 weeks after Robotic Prostatectomy
At the age of 70 my most recent treatment was a Robotic Prostatectomy after which pathology report was Gl 3+4 prostate cancer, pT3a (EPE and bladder neck invasion), N1 (1/15 nodes positive), multiple positive margins.( Prior to that I underwent Cryotherapy for prostate cancer in Mar 2012.) My PSA level
At the age of 70 my most recent treatment was a Robotic Prostatectomy after which pathology report was Gl 3+4 prostate cancer, pT3a (EPE and bladder neck invasion), N1 (1/15 nodes positive), multiple positive margins.( Prior to that I underwent Cryotherapy for prostate cancer in Mar 2012.) My PSA level
OLDSALTY2008
in
Advanced Prostate Cancer
5 months ago
Proteolysis-Targeting Chimeras (PROTACs): targeting cancer by deleting deleterious proteins?
There seem to be a kind of superiority of PROTACs over conventional inhibitors in treating prostate cancer. The article examines various targets for PROTACs in prostate cancer, including the androgen receptor and other critical oncoproteins, while addressing future prospects and challenges in this
There seem to be a kind of superiority of PROTACs over conventional inhibitors in treating prostate cancer. The article examines various targets for PROTACs in prostate cancer, including the androgen receptor and other critical oncoproteins, while addressing future prospects and challenges in this
Maxone73
in
Advanced Prostate Cancer
5 months ago
My trajectory after a "vacation" and a new metastasis
My backgound briefly (full details in Profile): aggressive form, BRCA2 mutation, RP in 2017, then 39 sessions of radiation, and 3 yrs of Lupron. All at Smilow Cancer Hospital. As a result, my PSA was undetectable for 2.5 years, and in 9/21 I was put on a "vacation" from treatment. Then PSA started
My backgound briefly (full details in Profile): aggressive form, BRCA2 mutation, RP in 2017, then 39 sessions of radiation, and 3 yrs of Lupron. All at Smilow Cancer Hospital. As a result, my PSA was undetectable for 2.5 years, and in 9/21 I was put on a "vacation" from treatment. Then PSA started
Istomin
in
Advanced Prostate Cancer
5 months ago
What's next after Xeloda?
Hi all, just got disappointing CT scan results showing strong progression after only 7 months on Xeloda. I've messaged my oncologist to find out what the next options may be so I can research them before our appointment. Would love to hear from anyone who has gone to the next step after Xeloda - what
Hi all, just got disappointing CT scan results showing strong progression after only 7 months on Xeloda. I've messaged my oncologist to find out what the next options may be so I can research them before our appointment. Would love to hear from anyone who has gone to the next step after Xeloda - what
LDR1
in
SHARE Metastatic Breast Cancer
10 months ago
Steroids and Radium 223
Hi Hopefully my husband will start Radium 223 in 4-6 weeks. He recently stopped abiraterone after 5 months as his PSA was doubling every month. While he was on abiraterone he was taking 2mgs of dexamethasone, although 1mg for the last month. He’s currently taking 6mgs of prednisilone but our question
Hi Hopefully my husband will start Radium 223 in 4-6 weeks. He recently stopped abiraterone after 5 months as his PSA was doubling every month. While he was on abiraterone he was taking 2mgs of dexamethasone, although 1mg for the last month. He’s currently taking 6mgs of prednisilone but our question
NLondon43
in
Advanced Prostate Cancer
5 months ago
Signatera tumor dna test
Has anyone heard of using the Signatera test from Natera to detect the presence of prostate cancer recurrence when PSA is rising but the PSMA PET scan is negative?
Has anyone heard of using the Signatera test from Natera to detect the presence of prostate cancer recurrence when PSA is rising but the PSMA PET scan is negative?
shihtzu124
in
Advanced Prostate Cancer
5 months ago
PSA Dropped after 22 days of Zytiga
On Nov 1, my cancer was diagnosed as castrate resistant. Abiraterone and Prednisone was added to Lupron. On November 3 I had a Lupron shot and started Abiraterone and Prednisone on November 10. Today I had a PSA test. My PSA dropped from 0.8 on November 1 to 0.44 today. I was not expecting such dramatic
On Nov 1, my cancer was diagnosed as castrate resistant. Abiraterone and Prednisone was added to Lupron. On November 3 I had a Lupron shot and started Abiraterone and Prednisone on November 10. Today I had a PSA test. My PSA dropped from 0.8 on November 1 to 0.44 today. I was not expecting such dramatic
dac500
in
Advanced Prostate Cancer
5 months ago
Here we go again
I was doing better, now the stomach pain is back worse than before. I guess its my own fault for eating McDonald's I was reading that unexplained weight loss could be colon cancer. I'm not sure it is unexplained as I have cut a lot of foods out. Processed foods . I'm just so scared to go to the
I was doing better, now the stomach pain is back worse than before. I guess its my own fault for eating McDonald's I was reading that unexplained weight loss could be colon cancer. I'm not sure it is unexplained as I have cut a lot of foods out. Processed foods . I'm just so scared to go to the
Ceasersalad
in
IBS Network
5 months ago
What category of Intermediate Risk Am I?
I am trying to make a decision regarding HT with RT. I am 78. I have CKD 3b, and a solitary kidney. I am 6.5 years in remission from UTUC kidney cancer. A number of papers indicate that HT could be detrimental to my kidney. Those with FIR PCa could avoid HT with little risk. The following is defined
I am trying to make a decision regarding HT with RT. I am 78. I have CKD 3b, and a solitary kidney. I am 6.5 years in remission from UTUC kidney cancer. A number of papers indicate that HT could be detrimental to my kidney. Those with FIR PCa could avoid HT with little risk. The following is defined
Nordman
in
Advanced Prostate Cancer
2 months ago
Oncolytic Virotherapy Platform Designed to Target All Tumor Sites: we will have some news soon, oncolytics are very promising (CLD-201)
– Preclinical models have demonstrated the ability to resist oncolytic virus inactivation by human serum and target diverse tumor types – Novel therapeutic approach allows for ease of administration, increased cost-effectiveness, and the ability to reach a broad patient population Enough for me to
– Preclinical models have demonstrated the ability to resist oncolytic virus inactivation by human serum and target diverse tumor types – Novel therapeutic approach allows for ease of administration, increased cost-effectiveness, and the ability to reach a broad patient population Enough for me to
Maxone73
in
Advanced Prostate Cancer
2 months ago
Combine standard care with alternative care
The University of Maryland reported two cases of terminated PCs by combining standard care treatment with an alternative treatment. By reducing the PSAs to less than 3, the clioquinol + zinc killed more cancer than testosterone could renew, therefore termination. My PSA in three months went from 58
The University of Maryland reported two cases of terminated PCs by combining standard care treatment with an alternative treatment. By reducing the PSAs to less than 3, the clioquinol + zinc killed more cancer than testosterone could renew, therefore termination. My PSA in three months went from 58
agnut
in
Fight Prostate Cancer
5 months ago
Swallowing difficulties 5 months post-op
Hi everyone. I’m 46 and had keyhole oesohagectomy surgery 5 months ago for T3N1M0 adenocarcinoma. I’ve recovered really well in most ways. No reflux and sleeping well. I’ve gained 2 stone (12.7kg) since my post-op weight (having lost 4 stone since my symptoms began) and I feel fit and healthy BUT I
Hi everyone. I’m 46 and had keyhole oesohagectomy surgery 5 months ago for T3N1M0 adenocarcinoma. I’ve recovered really well in most ways. No reflux and sleeping well. I’ve gained 2 stone (12.7kg) since my post-op weight (having lost 4 stone since my symptoms began) and I feel fit and healthy BUT I
ScottishLondoner
in
Oesophageal & Gastric Cancer
5 months ago
Repeat Lutetium/ Pluvicto treatment
Hello all, I am just curious if anyone has experience doing additional lutetium treatments. I did three lutetium treatments from September 2021 to January 2022. My Denver oncologist is concerned about bone marrow toxicity , but he does not have enough experience with this treatment to say for sure.
Hello all, I am just curious if anyone has experience doing additional lutetium treatments. I did three lutetium treatments from September 2021 to January 2022. My Denver oncologist is concerned about bone marrow toxicity , but he does not have enough experience with this treatment to say for sure.
Eugmn
in
Advanced Prostate Cancer
3 months ago
24 Year Old Female
GRAPHIC PICTURE - BLOOD 🩸 hello, would love some advice. I’ve been having rectal bleeding for a year now, but recently it got worse and it’s been filling up the toilet. I’ve ignored it because I’ve had no other pain anywhere and I’ve felt relatively normal, but revelry I’ve had stomach pains and major
GRAPHIC PICTURE - BLOOD 🩸 hello, would love some advice. I’ve been having rectal bleeding for a year now, but recently it got worse and it’s been filling up the toilet. I’ve ignored it because I’ve had no other pain anywhere and I’ve felt relatively normal, but revelry I’ve had stomach pains and major
muffinismycatsname
in
Colon Cancer Connected
5 months ago
Low Volume Low PSA Metastatic PC.
When my Oncologist refers to Low volume, Low PSA Oglimetastic PC, what is he saying about my disease? I’ve been oo Abiraterone followed by Xtandi with Lupron every 3 months and Zometa every 6.
When my Oncologist refers to Low volume, Low PSA Oglimetastic PC, what is he saying about my disease? I’ve been oo Abiraterone followed by Xtandi with Lupron every 3 months and Zometa every 6.
NDJIM
in
Advanced Prostate Cancer
5 months ago
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