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High bilirubin
My husband has been on Abiraterone/prednisone for 10 months and Lupron for 12 months and recently has had an increase in his bilirubin 2.5. His MO has stopped the abiraterone temporarily and has ordered a sonogram of his liver/gallbladder and weekly monitoring of bloodwork. He is also slightly anemic
My husband has been on Abiraterone/prednisone for 10 months and Lupron for 12 months and recently has had an increase in his bilirubin 2.5. His MO has stopped the abiraterone temporarily and has ordered a sonogram of his liver/gallbladder and weekly monitoring of bloodwork. He is also slightly anemic
Averagegilbert
in
Advanced Prostate Cancer
16 days ago
Radium 223 + Enzalutamide increase rPFS in castration resistante prostate cancer
As Tall Allen posted, here is the link to the numbers: https://www.onclive.com/view/addition-of-radium-223-to-enzalutamide-significantly-improves-rpfs-and-os-in-mcrpc
As Tall Allen posted, here is the link to the numbers: https://www.onclive.com/view/addition-of-radium-223-to-enzalutamide-significantly-improves-rpfs-and-os-in-mcrpc
Maxone73
in
Advanced Prostate Cancer
17 days ago
How did your Docetaxel rechallenge compare to your original chemo treatment?
Mr. Spouse 21 is starting a Docetaxel rechallenge next week--3 rounds then another PMSA-PET scan. If you did a Docetaxel rechallenge as well, can you compare your early experiences with the rechallenge in terms of side effects and effectiveness and where you are now? He developed neuropathy despite using
Mr. Spouse 21 is starting a Docetaxel rechallenge next week--3 rounds then another PMSA-PET scan. If you did a Docetaxel rechallenge as well, can you compare your early experiences with the rechallenge in terms of side effects and effectiveness and where you are now? He developed neuropathy despite using
spouse21
in
Advanced Prostate Cancer
17 days ago
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Xofigo+Xtandi beats Xtandi alone for mCRPC
Silke Gillessen presented the early results of PEACE3 at ESMO 2024. Compared to Xtandi alone, Xofigo+Xtandi: • improved radiographic progression-free survival by 31% • improved overall survival by 31% These were men who had predominantly bone metastases and all received a bone strengthening agent
Silke Gillessen presented the early results of PEACE3 at ESMO 2024. Compared to Xtandi alone, Xofigo+Xtandi: • improved radiographic progression-free survival by 31% • improved overall survival by 31% These were men who had predominantly bone metastases and all received a bone strengthening agent
Tall_Allen
in
Advanced Prostate Cancer
17 days ago
Estrogen content for bone health
I had PSA of 250 Gleason 9/10 in 2019 Mar. Was under ADT regime from Jun 19 followed by IMRT in Nov 19. It was 39 sessions of 78 Gy to prostrate, prostrate bed, pelvic nodes. Later in Sep 22 PSA started to rise indicating BCR. In Jan 22 underwent Orchidectomy followed by Nubeqa for 19 months now. I've
I had PSA of 250 Gleason 9/10 in 2019 Mar. Was under ADT regime from Jun 19 followed by IMRT in Nov 19. It was 39 sessions of 78 Gy to prostrate, prostrate bed, pelvic nodes. Later in Sep 22 PSA started to rise indicating BCR. In Jan 22 underwent Orchidectomy followed by Nubeqa for 19 months now. I've
binati
in
Advanced Prostate Cancer
18 days ago
PSA jump from 0.01 to 3.0 6 months after surgery
and path I just got my 2nd PSA result today and it showed my level at 3.0...My prosectomy was done 3/21/24 and surgeon took lymp nodes, floor tissue, margins, etc and path report showed pristine results. I also had PSMA and MRI with contrast pre-surgery and both scans showed no spread and fully contained
and path I just got my 2nd PSA result today and it showed my level at 3.0...My prosectomy was done 3/21/24 and surgeon took lymp nodes, floor tissue, margins, etc and path report showed pristine results. I also had PSMA and MRI with contrast pre-surgery and both scans showed no spread and fully contained
wharr
in
Prostate Cancer Network
18 days ago
PSMA pet scan
Has anyone had a Pylarify (PSMA) pet scan showing no prostate cancer spread but knew that you had some metastasis in at least one lymph node (seen in an older scan and confirmed by biopsy). I know that there are people who are PSMA negative...not sure if my husband is one. He has had a prostatectomy,
Has anyone had a Pylarify (PSMA) pet scan showing no prostate cancer spread but knew that you had some metastasis in at least one lymph node (seen in an older scan and confirmed by biopsy). I know that there are people who are PSMA negative...not sure if my husband is one. He has had a prostatectomy,
mountain6
in
Advanced Prostate Cancer
19 days ago
FYI ... Early-Onset Colorectal Cancer
Early-onset colorectal cancer (EOCRC) is colon cancer or rectal cancer diagnosed before the age of 50. It is also known as early age onset CRC and young-onset colorectal cancer. Early-onset CRC accounts for about 10% of colon cancers and 15-20% of rectal cancers. For more info .... https://www.globalcca.org
Early-onset colorectal cancer (EOCRC) is colon cancer or rectal cancer diagnosed before the age of 50. It is also known as early age onset CRC and young-onset colorectal cancer. Early-onset CRC accounts for about 10% of colon cancers and 15-20% of rectal cancers. For more info .... https://www.globalcca.org
GCCA-Survivor
Administrator
in
Colon Cancer Connected
19 days ago
Help: Use of ODM 208 during Phase 3 clinical trials to replace Docetaxel for treatment after Abiraterone - Case Peru
Hello, my father suffers from prostate cancer with bone metastasis. He was taking Abiraterone, and because the cancer has advanced and his PSA has increased in recent months, the use of Abiraterone was cancelled. Now they have suggested chemotherapy with Docetaxel + Celendronic Acid. The hospital contacted
Hello, my father suffers from prostate cancer with bone metastasis. He was taking Abiraterone, and because the cancer has advanced and his PSA has increased in recent months, the use of Abiraterone was cancelled. Now they have suggested chemotherapy with Docetaxel + Celendronic Acid. The hospital contacted
DiegoFerruaPE
in
Advanced Prostate Cancer
19 days ago
SECuRE trial (Cu 67) advances: No dose limiting toxicities and strong preliminary efficacy data
It keeps being promising, but keep an eye also on Pb 212, which on paper should be even better for prostate cancer. After 2 cycles: "Early preliminary efficacy assessment shows a reduction in PSA levels following treatment in both participants who have completed the DLT period. In the weeks following
It keeps being promising, but keep an eye also on Pb 212, which on paper should be even better for prostate cancer. After 2 cycles: "Early preliminary efficacy assessment shows a reduction in PSA levels following treatment in both participants who have completed the DLT period. In the weeks following
Maxone73
in
Advanced Prostate Cancer
19 days ago
Two or three years of ADT?
My two-year-course if Lupron and abiraterone will be done in March 2025. My MO is saying 2 years is sufficient but I see some people suggesting 3 years. My situation. Dx in Feb 2023, PSA of 27. Gleason 4+3, BRACA2+, PSMA Pet showed three lymph nodes in pelvic area. 73 years old. Also diabetic and
My two-year-course if Lupron and abiraterone will be done in March 2025. My MO is saying 2 years is sufficient but I see some people suggesting 3 years. My situation. Dx in Feb 2023, PSA of 27. Gleason 4+3, BRACA2+, PSMA Pet showed three lymph nodes in pelvic area. 73 years old. Also diabetic and
BobC1234
in
Advanced Prostate Cancer
19 days ago
Hello! BPH here (used testosterone). Need advice and talk to someone...
47 years old, fit and healthy... Started last month with BPH symptoms. My prostate is almost 50g (the limit is 30g for my age). That is too much or nah??? I've only taken 02 pills of dutasteride + tamsulosin hydrochloride, and already no sperm during orgasm. Pretty fast, right? I'm very worried about
47 years old, fit and healthy... Started last month with BPH symptoms. My prostate is almost 50g (the limit is 30g for my age). That is too much or nah??? I've only taken 02 pills of dutasteride + tamsulosin hydrochloride, and already no sperm during orgasm. Pretty fast, right? I'm very worried about
Kayo47
in
Prostate Cancer Network
19 days ago
Sad & Scared
My husband began Docetaxel in July. At the time he PSA was 47. After treatments began his PSA progression was 47—32—18 We were so encouraged. After his 3rd Infusion today, his PSA went up to 19.2 I know it is only slight but yet not going downward. Does this mean he has potentially reached nadir
My husband began Docetaxel in July. At the time he PSA was 47. After treatments began his PSA progression was 47—32—18 We were so encouraged. After his 3rd Infusion today, his PSA went up to 19.2 I know it is only slight but yet not going downward. Does this mean he has potentially reached nadir
JolleySprings
in
Advanced Prostate Cancer
19 days ago
Hemin may be useful as prodrug for prostate cancer. It strongly induced caspase-3 activation, PARP degradation, and apoptosis in PC-3 cells
Only an invitro study but Hemin is already used to treat acute porphyria. “Given that hemin has been safely administered as a daily infusion at doses ranging from 1 to 4 mg/kg for 3 to 14 days in the treatment of porphyria [32], it holds significant promise for drug development.” Anticancer Effect of
Only an invitro study but Hemin is already used to treat acute porphyria. “Given that hemin has been safely administered as a daily infusion at doses ranging from 1 to 4 mg/kg for 3 to 14 days in the treatment of porphyria [32], it holds significant promise for drug development.” Anticancer Effect of
Graham49
in
Fight Prostate Cancer
20 days ago
Another one of many
PSA tested in June 2023 due to a friend who had an issue and encouraged testing. PSA at 43, second test at 40. Biopsy ordered which came in at 4 +5. Moved treatment to UCLA where a PET scan was ordered. Metastatic cancer in 8 locations with 1 lymph node effected, remaining locations spread through different
PSA tested in June 2023 due to a friend who had an issue and encouraged testing. PSA at 43, second test at 40. Biopsy ordered which came in at 4 +5. Moved treatment to UCLA where a PET scan was ordered. Metastatic cancer in 8 locations with 1 lymph node effected, remaining locations spread through different
Wave-Runner
in
Advanced Prostate Cancer
20 days ago
Switched from Lupron to Orgovyx, back to Lupron
I was on Lupron for approximately 7 years. I decided to switch to Orgovyx 6 months ago. I seem to have difficulty with the discipline to take pills at the same time every day. I am switching back to Lupron, but my Urologist wants me to stop Orgovyx and take Bicalutamide for 14 days before getting the
I was on Lupron for approximately 7 years. I decided to switch to Orgovyx 6 months ago. I seem to have difficulty with the discipline to take pills at the same time every day. I am switching back to Lupron, but my Urologist wants me to stop Orgovyx and take Bicalutamide for 14 days before getting the
SF22
in
Advanced Prostate Cancer
20 days ago
WTF!! Something escaped my lens: phase 1 trial for solid tumors
From 2011...I must investigate where they are now, I thought HP90 inhibition through alvespimycin was something new (from one of the articles I have posted today), but it has been around at least since 2011...and look at the results (ok, single patient) on prostate cancer. https://aacrjournals.org/clincancerres
From 2011...I must investigate where they are now, I thought HP90 inhibition through alvespimycin was something new (from one of the articles I have posted today), but it has been around at least since 2011...and look at the results (ok, single patient) on prostate cancer. https://aacrjournals.org/clincancerres
Maxone73
in
Fight Prostate Cancer
20 days ago
kieran2018
hi everyone, I was diagnosed with stage 4b ovarian cancer in 2020. I underwent surgery had chemo paclitaxel and carboplatin. I commenced on olaparib for two years and my cancer had spread . I then underwent another six cycles of chemo carboplatin and calyx with a partial response. I haven’t been on
hi everyone, I was diagnosed with stage 4b ovarian cancer in 2020. I underwent surgery had chemo paclitaxel and carboplatin. I commenced on olaparib for two years and my cancer had spread . I then underwent another six cycles of chemo carboplatin and calyx with a partial response. I haven’t been on
Kieran2018
in
My Ovacome
20 days ago
Genomics
https://www.biospace.com/article/releases/epic-sciences-unveils-definembc-a-novel-blood-based-test-designed-to-improve-care-for-metastatic-
breast
-
cancer
-patients/ 🙏🏻
https://www.biospace.com/article/releases/epic-sciences-unveils-definembc-a-novel-blood-based-test-designed-to-improve-care-for-metastatic-
breast
-
cancer
-patients/ 🙏🏻
muzzatron
in
SHARE Metastatic Breast Cancer
1 year ago
TV show: This Morning
Hi there. At my Pilates class this morning, a lady told me that This Morning had done a piece on abdominal surgery and how this can have a longterm effect on your shoulders. I don't know whether this was part of Gynae Cancer Awareness Month. Tried to find it online with no success. Did anyone see it
Hi there. At my Pilates class this morning, a lady told me that This Morning had done a piece on abdominal surgery and how this can have a longterm effect on your shoulders. I don't know whether this was part of Gynae Cancer Awareness Month. Tried to find it online with no success. Did anyone see it
candyapplegrey
in
My Ovacome
22 days ago
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