Now that I am finally recovering from the flu I am going to post what the daily regimen of supplements I am taking. Prior to listing the vitamins, minerals, amino acids....I am taking, I need to relate a little history. I have a degree in sculpture and was exposed to many chemicals including toluene. Years later I was a greens keeper and was further exposed to insecticides, herbicides, algaecides and for 1 day, large doses of Monsanto's Roundup.
“The research found that being exposed to bug or weed killers and solvents increased the risk of developing Parkinson's disease by 33 to 80 per cent.”
Parkinson's disease has a heavy association with chemicals and after my exposure I had a pre-parkinsonian symdrome which included: lost sense of smell, depression, anxiety, ED, chest tremors, back stiffness, muscular weakness, fatigue and mental confusion. Upon examining the possible causes of PD the elephant in the corner was toxic chemicals and at the time I thought I had PD as caused by pesticides, herbicides, fungacides, rotenone, MPTP, maneb, etc....so I searched for studies featuring supplements which attenuated the effects of chemicals/PD models so I started to take every supplement with affects mitochondria.
The first supplement I took was DHA/EPA omega 3 and I am currently taking 910 mg (448 EPA + 308 DHA + other omega 3s + 154 mg) x 3 meals (2,730 mg total) . Up to 7,100 mg/day of fish oil can be taken but at that high level a blood test is required. Fish oil is a blood thinning agent and can be dangerous if taken with other blood thinning agents like Warfarin.
DHA omega 3, Parkinson's disease & MPTP:
Omega-3 fatty acids protect against Parkinson's, study says
The second supplement I took was Coenzyme Q10. I read a study that stated 1,200 mg/day of ubiquinone slowed the progression of PD by 44% so I started taking 1,200 of coq10.
Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism
Interestingly, when I started taking 1,200 mg/day of ubiquinone it had a profound effect on me but at the time I was already taking large doses of fish oil and did not consider that the 2 supplements were working together for the positive effect I was experiencing. Years later I ran out of fish oil and was unconcerned about replacing the supplement. Hey I was taking CoQ10 right? After about 7-10 days of not taking fish oil my chest fasciculations (not a PD symptom) started to come back and there was some pain associated with the twitching. So I once again started taking the combo together and I felt fine (again). What might have possibly happened is the high DHA/EPA content helped to absorb the CoQ10. Most Coq10 is fat soluble and required a major source of fat to ensure its absorption.
The MJFF tested ubiquinone and abandoned it for other supplements. Considering that ubiquinone is one of three types of CoQ10, ubiquinone, ubiquinol and PQQ, I think this is rather short sighted but hey, it is the MJFF, right?
Finally, coq10 has been tested against various chemicals which have been implicated in PD and has worked well in animal modes or the lab dish. So why do most PD patients not respond to CoQ10? Perhaps the cause of the disease is not chemicals as is the generally accepted wisdom and the cause is something else. Or chemicals are a causal co-factor.
The following study features water soluble CoQ10 mitigating the effects of rotenone in a 'in vitro' model of PD:
Water-Soluble Coenzyme Q10 Reduces Rotenone-Induced Mitochondrial Fission
“Hence, water-soluble CoQ10 may have therapeutic potential in treating patients with Parkinson’s disease.”
What other supplements do I take?
600 mg/day N acetylcysteine
600 mg R-alpha lipoic acid + 1,000 acetyl l carnitine (rotenone cellular model)
100 mg thiamine/B1
100 mg riboflavin/B2
300 mg niacin/B3 (flushing form)
1,500 mg niacinamide/B3 (non-flushing form)
400 mcg methyltetrahydrofolic acid/B9
5 mg methylcobalamin/B12
10 mg/day piperine
200 mcg selenomethionine
250 baicalin from Scultellaria baicalensis + 400 mg Full Sprectrum - Scutellaria baicalensis
1,000 mg Milk thistle
200 mg L-theanine
500 mg magnesium threonate + magnesium chloride
3,000 mg/day vitamin C
22mg/day of zinc piccolinate
I take 5 ibuprofen a week.
OTHER SUPPLEMENTS I USED:
Polygonum multiflorum (MAO-b inhibitor)
Ling Zhi mushroom
Supplements used on a rotational basis.
50% levodopa from mucuna puriens
99% pure levodopa from mucuna pruriens
94%+ pure EGCG