Ingredients to prevent or slow progression of PD - Knox Van Dyke - Dept of Biochemistry and Molecular Pharmacology, West Virginia University

[Bolt_Upright]

I give Doctor Knox Van Dyke credit. He put his name on it and did not spare any details.

asclepiusopen.com/clinical-...

Ingredients to prevent or slow progression of PD (2018):

- Inosine - 4 g/day in divided doses inosine or sustained release inosine.

- Tocotrienol - special form of Vitamin E capsules -1 capsule every 12 h. Available from Endurance Products - Oregon.

- Fish oil with omega 3 fatty acids - DHA/EPA (500- 1000 mg/day); make sure they are coated tablets.

- Sustained release 5 hydroxytryptophan - 500 mg every 12 h. (Yikes! Might have to skip this one healthunlocked.com/cure-par... )

- L-tyrosine - at least 500 mg capsules every 8 h.

- Astrazanthin capsules 12 mg/day.

- Krill oil - 1 capsule/day.

- Tylenol - arthritis formula-sustained release 2-650 mg tablets/8 h.

- N- acetylcysteine sustained release - 600 tablet take 1/day

- Sustained release niacinamide - 500 mg tablets - take 2-3/day get from endurance products, Oregon.

- Levo-DOPA/carbidopa dose determined by the physician and best avoided because of toxicity. If Levo-DOPA alone would be available, this would be a more judicious choice.

- Chloroquine 200-300 mg every 3rd day. The dose and timing should be confirmed by a physician.

- Vitamin C - 2 g every 12 h or sustained release Vitamin C - 2 g every 12 h.

[park_bear]

>"- Inosine - 4 g/day in divided doses inosine"

OMG NO!

Inosine is for raising uric acid levels. Worse than worthless an - an invitation to disaster. Details here:

Association ≠ Causation. Do Not Be Led Astray By This Popular Health Guru

tinyurl.com/ycsr4cfu

[Bolt_Upright in reply to park_bear]

I guess he put this list together (2018) before the crash and burn study on inosine took place.

[kevowpd in reply to Bolt_Upright]

Which should tell you what you need to know.

[Bolt_Upright in reply to kevowpd]

Well 2018 is only 3 years ago. I think finding the right combination of things is kind of like drawing a royal flush. It's hard. He might have some of the pieces right.

Although his doses are really high and he did misspell Astaxanthin (that is a red flag).

[Bolt_Upright in reply to Bolt_Upright]

And Astaxanthin looks like a dead end also:

Astaxanthin is neuroprotective in an aged mouse model of Parkinson’s disease ncbi.nlm.nih.gov/pmc/articl...

We observed that AXT preserved neurons in the substantia nigra of both young and aged mice that were exposed to the MPTP neurotoxin. However, AXT was less efficacious in the aged animals, as AXT was not able to protect against the MPTP induced loss of tyrosine hydroxylase (TH) throughout the aged nigro-striatal circuit. This disparity in the neuroprotective effect of AXT suggests that aging is a critical factor to consider during the development of novel therapeutics for neurodegenerative diseases and should be more rigorously evaluated in preclinical models.

[kevowpd in reply to Bolt_Upright]

I was unnecessarily cryptic. It's not about the timing of the studies. What I mean is this:

- just because someone is willing to be prescriptive doesn't mean they have the answers.

- even if they strap a whole lot of 'evidence' to their claims, a critical failure may occur somewhere between that theory and the implementation. This is especially an issue in PD, given how many questions remain outstanding regarding the etiology and pathogenesis.

When the topic of the status of research comes up here, many posters bemoan the state of play regarding the development of a disease modifying treatment, and frequently those complaints represent a concern around the relative lack of knowledge about how PD actually works. And as a member of an unenviably long line of familial PD, I share that frustration to no end. But if we are to conclude in one breath that we don't nearly know enough, then it's very unlikely that one person is going to strike gold with their 'protocol'. Or that even one ingredient in their recipe is going to he valid.

[Bolt_Upright in reply to kevowpd]

Well said! The scientists really don't know what is cause and what is effect.

All of these protocols are shots in the dark (fortunately if you take enough shots into the dark you are bound to hit something. Most likely somebody you did not intend to shoot).

[kevowpd in reply to Bolt_Upright]

fortunately if you take enough shots into the dark you are bound to hit something

And how do you get comfortable that you won't hit something that accelerates your lewy body pathology?

[Bolt_Upright in reply to kevowpd]

Yes, that was the point of my cautionary postscript "Most likely somebody you did not intend to shoot". You make a very valid point. We could be doing harm.

[kevowpd in reply to Bolt_Upright]

Ah right, now I'm with you. Yes.

[kevowpd in reply to Bolt_Upright]

Herein lies my own difficulty with all of this. If I thought supplements and vitamins had no possible downsides, I'd drop 10k on Amazon or Iherb in a heartbeat and I'd chug the entire spectrum every day. But I'm far from convinced that each of the supplements that are mentioned here fairly frequently are free of risk regarding the possibly acceleration of my PD. We just don't know enough, especially given how poorly stratified the PD population is into subtypes.

[Bolt_Upright in reply to kevowpd]

Yes. The one I take that worries me the most is NAC. I think that is the most aggressive one on my list.

A lot of my effort is fixing the microbiome. So I feel pretty safe that the Specific Carbohydrate Diet, resistant starches, and Zeolite Pure is not going to make things worse (and judging using the Bristol Scale, these steps are working!).

I'm not worried about the B1, B3 and B12 or the amino acids (Taurine, Glycine, and Inositol). The Selenium might cause me other issues, but not PD issues.

Not worried about Butyric Acid, Lion's Mane, or Magnesium. I don't take huge doses.

And feel Cinnamon, Mannitol, and Bee Pollen and Royal Jelly are not going to cause much of an issue.

Also started up with MSM. Kind of a wild card, but basically sulfur.

And everybody knows Melatonin is safe.

[Hidden in reply to Bolt_Upright]

In addition to reservations about NAC, Vinpocetine leaves me with some apprehensions. I continue to be surprised you are not taking Citicoline.

Zeolite Pure is for cleansing but cleansing what specifically?

[Bolt_Upright in reply to Hidden]

I should stop acting like a Zeolite salesman. It just intrigues me. Besides iron chelation, which I just discovered could be useful, here are notes from my previous posts:

healthunlocked.com/cure-par...

healthunlocked.com/cure-par...

these are all the things I have heard need to be address with PD:

1: Inflamation - ZC is anti-inflamatory.

2: It is speculated there is/was a pathogen in our gut - ZC seems to take out heavy metals, molds, viruses, mycotoxins, and fungus. I'm not saying it is the best at this, but it seems to be pretty broad in its range of targets.

3: It has been speculated that intestinal permeability is an issue for us - ZC tightens up the intestinal permeability (leaky gut).

4: ZC is an anti-oxidant.

5: ZC boosts Gutathione.

6: ZC is able to reduce stress and improve sleep, producing a soothing effect in humans.

7: PMA-ZC (tribomechanically activated zeolite clinoptilolite) is capable of improving the ecosystem of intestinal microbial flora.

"Based on the data collected on animal models and on a few clinical trials, it can be speculated that the general state of wellbeing generated by ZC, and in particular by TMAZ and PMA-ZC, is due to its detoxifying, anti-inflammatory and antioxidant action in the intestine. Indeed, recent findings of the importance of the gut microbiome in the regulation of immunity and its interconnection with the central nervous system could at least partially explain the results obtained using animal models treated with PMA-ZC. ZC could purify the internal environment of our body, maintain gut microbiota homeostasis for healthy brain activity, improve the antioxidant and endogenous anti-inflammatory activities thereby improving the overall wellbeing of the patient."

Am I desperate? Yes.

[Hidden in reply to Bolt_Upright]

Where did the segment in quotes come from? Quote from who?

[Bolt_Upright in reply to Hidden]

It's from this 2019 article: Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral ncbi.nlm.nih.gov/pmc/articl...

I included more of the quote this time as it does also have questions:

Due to the binding capacities, ZC has been generally used in the zootechnical field for water purification and decontamination, contributing to the improvement of livestock health. Furthermore, environmental contaminants accumulate throughout the food chain and are therefore part of foodstuff. For this reason, PMA-ZC is studied and used for oral supplementation to bind toxic substances such as ammonia or heavy metals in the milieu of the gastro-intestinal tract. Furthermore, PMA-ZC is capable of improving the ecosystem of intestinal microbial flora. Based on the data collected on animal models and on a few clinical trials, it can be speculated that the general state of wellbeing generated by ZC, and in particular by TMAZ and PMA-ZC, is due to its detoxifying, anti-inflammatory and antioxidant action in the intestine. Indeed, recent findings of the importance of the gut microbiome in the regulation of immunity and its interconnection with the central nervous system could at least partially explain the results obtained using animal models treated with PMA-ZC. ZC could purify the internal environment of our body, maintain gut microbiota homeostasis for healthy brain activity, improve the antioxidant and endogenous anti-inflammatory activities thereby improving the overall wellbeing of the patient. Despite all this, still, only a few studies have defined the molecular mechanisms underlying the positive effects of all ZC.

Furthermore, several important questions are still unanswered: What is the molecular mechanism that increases the antioxidant activity of SOD and GSH in experimental models treated with ZC? What is the translational value of the action of ZC on β-amyloid levels? Is there risk of reducing the contribution of mineral salts due to the ion exchange action of ZC? Finally, is there remote danger of ZC crossing the intestinal wall?

In conclusion, preclinical research on zeolites was not aimed at finding a new drug, but a food supplement that can improve lifestyle and be combined with traditional pharmacological treatment. In fact, recent evidenced suggested a promising detoxifying role of ZC in the removal of toxic metabolites produced by drugs chronically administered during chemotherapy, diabetes, or cardiovascular diseases. However, new and extensive research will be needed to explore all the potential benefits that ZC and other specific modified ZC can produce on human health.

[glenandgerry in reply to Hidden]

CC, are you taking Citicoline? If so, what made you decide to take it & do you derive any benefit? Thanks

Gerry

[Hidden in reply to glenandgerry]

Dr. Dale Bredeson recommends it for ALZ So I researched it months ago for neuro protection

[park_bear in reply to Bolt_Upright]

I set forth the safety considerations for the use of NAC here:

NAC May Reduce the Severity of Coronavirus Respiratory Illness

tinyurl.com/y2yl65sh

It has been used extensively in humans with no serious adverse effects reported at moderate doses. It is used at high dosages intravenously for recovery from liver toxicity, with some reports of anaphylactoid reactions. It has caused some serious adverse effects in animals, but those adverse effects have not been reported in humans. It has not done anything for my Parkinson's but I did take it for other reasons.

[LindaP50 in reply to park_bear]

Integrative doctors (and others) stress that NAC is a precursor for Glutathione and subscribe both in treatment for Lyme Disease.

[glenandgerry in reply to LindaP50]

I didn't know NAC is used as a treatment for Lyme.

[Sydney75 in reply to park_bear]

NAC has to been taken on an empty stomach to increase bioavailability.

[Bolt_Upright in reply to Sydney75]

And I read NAC should be taken at night as overnight is when it does its thing. And it is more effective if taken with Glycine.

[Hidden in reply to Bolt_Upright]

My (unschooled) thought is that anything taken in a large amount all at once has a higher likelihood of being excreted rather than utilized. But I can attest to getting noticeable benefit when taken on an empty stomach in divided doses throughout the day.

[Hidden in reply to Hidden]

meh... of course I do not mean it would ALL be excreted.

[Hidden in reply to Bolt_Upright]

Also started up with MSM. Kind of a wild card, but basically sulfur.

I just saw something in chartist's post about making magnesium oil that says why he isn't recommending MSM anymore.

[Hidden in reply to Bolt_Upright]

It's in this post: healthunlocked.com/cure-par...

Something about side effects he'd never heard of before.

Conclusion was that he wasn't going to recommend it anymore.

[parkie13 in reply to Hidden]

Art was taking a huge amount of it.

Our soil is deficient in Sulfur, we are all deficient in Sulfur mineral.

[LAJ12345 in reply to park_bear]

Probably means inositol?

[Bolt_Upright in reply to LAJ12345]

Inosine? There was a time when people thought increasing uric acid would be good for PD. Inosine boosts uric acid. Not a good idea.

[Hidden]

Interesting distinction about the CL

[Bolt_Upright in reply to Hidden]

Yes, the main point of his article is he does not believe in CL.

I found him looking for Hydroxichloroquine as a PD treatment.

[Parkinsonjisung in reply to Bolt_Upright]

To me, if a doctor is against levodopa, they're not worth listening to.. its a sign they've never worked directly with a parkinson patient

[Hidden in reply to Parkinsonjisung]

You are not distinguishing between Levodopa and Carbidopa.

[Parkinsonjisung in reply to Hidden]

Ya, but levodopa generally comes with carbidopa or a similar drug because its much more efficacies with it so the overall point the author is making is stupid. You can get levodopa by itself from mucuca beans but you're essentially guessing the dosage and its completely unregulated

[Psalm1 in reply to Parkinsonjisung]

Carbidopa enhances the absorption of Levodopa, thus the combination.

[gwendolinej]

Have you added these to your stack 😆

[Coling]

My interest was peeked when the article said that death rates increased with introduction of combined Levadopa with Cabidopa (or Benserazide). He cites 'Hinz M, Cole T. The Parkinson's disease death rate: Carbidopa and vitamin B6. Clin Pharmacol Adv Appl 2014. DOI:10.20147/cpaa.570707."

I looked up the article and it says "Carbidopa is postulated to contribute to the increasing Parkinson's disease death rate and to the classification of Parkinson's as a progressive neurodegenerative disease. It may contribute to L-dopa tachyphylaxis."

My poor brain finds this difficult to unravel. Is there anyone out there that has asked this question of their neurologist?

[Bolt_Upright in reply to Coling]

I see that article was retracted. I'm not sure why, but a number of Marty Hinz articles have been retracted.

[Sydney75]

I read carbidopa can deplete B6 but that can be corrected by low dose B vitamins taken a few hours away from last C/L dose.