My Stack - Need Suggestions

[JayPwP]

I have:

Vitamin D3 600 IU+K2 55mcg plant based

Vitamin D3 5000 IU

Vitamin B1 HCL 500 mg capsule

Vitamin B1 HCL 100 mg capsule

Vitamin B3 Nicotinic Acid 100 mg capsule

Methyl B Complex

Melatonin 10 mg

Magnesium L-Threonate

Vinpocetine 10 mg

Probiotics 50 billion CFU 16 strain blend

PS128 and PS128+K21

Ginkgo Biloba 120 mg + Bacopa 380 mg

Turmeric 500 mg

Lithium Orotate 5 mg

Ambroxol 75 mg

Ashwagandha 250 mg tab

Badam Rogan Shirin Almond oil

Vitamin C 1000 mg tab

MCT oil

Omega 3 Algae oil 500 mg DHA

Currently only taking L/C 200/50 mg twice a day. All the above stopped.

Any suggestions welcome on how and what to take... Thanks.

[CaseyInsights]

Jay, this is an impossible ask!

Start here:

What problems are you trying to resolve and do you have a definite diagnosis of Parkinkinson?

Then pick the substances that bring relief, and the others you sense would be helpful.

There is no other way, where supplements are concerned. Never mind the research papers: at an individual level it is all guess work. 🌹

P.S: Maybe you can take some of the guess work out of this with extensive testing. But it sure as hell is expensive.

[JayPwP in reply to CaseyInsights]

Thanks

[CaseyInsights in reply to JayPwP]

Here are some lab test that may be useful in trying to determine what supplements might bring the most benefit. The list is by no means exhaustive.

‌1. Homocysteine

* B6, B12 & Folate status (You can test for these individually also)

2. Insulin Resistance

Fasting Insulin. HbA1c. Fasting Glucose

3.Inflammation

hs-CRP (high-sensitivity C-Reactive Protein) |

The ratio of albumin to globulin in your blood (A/G ratio)

ESR - Erythrocyte Sedimentation Rate

4. Vitamin D (Immunology)

5. Thyroid

TSH. Free T3. Free T4. Reverse T3

6. Uric Acid - Serum

7. Iron/TIBC/Ferritin

8. Electrolytes (Na, K, Cl)

>>>>>

Your doctor may suggest

(1) Liver Function Test

(2) Complete Blood Profile

(3) Renal Function Test

(4) Lipid Profile / (Cholesterol Test)

Hang tuff!

[JayPwP in reply to CaseyInsights]

Thanks again. Let me check these parameters.

[CaseyInsights]

Finally Jay you can use what I call ‘frameworks’ to put together a stack.

A ‘framework’ involves an explanation of disease evolution and a stack of supplements and lifestyle modifications, that hopefully work in synergy to alleviate symptoms and address root causes of the problem.

Here are three ‘frameworks’.

1. The first was used extensively when my spouse was first diagnosed. Never reach the dosage levels suggested, but it did give me a starting point to put together a stack in the early days.

chiro.org/Graphics_Box_NUTR...

2. Here is one from Frank Church - a retired Professor (Pathology and Laboratory Medicine) with PD

pdfs.journals.lww.com/topic...

3. And this one I find interesting. I have incorporated some ideas, may do more in the future.( Do note the suggested use of Inosine is a no-no)

ncbi.nlm.nih.gov/pmc/articl...

So there we are my friend. All frameworks - and I have a few more in my library - are just guidepost. Frameworks do help you in ‘systems thinking’ and I find these frameworks guide my thought processes in putting together a stack.

You can of course adopt any one of them wholesale, but for me this remains a do it yourself exercise.

Hang tuff!

P.S: None of these frameworks include Niacin or Lithium which I consider vital to improve the QOL of my spouse. Framework one does have NADH, which comes close. 🌺

[ghoegap in reply to CaseyInsights]

Thanks for the input! Much there that is new to me!

[JewelryGal in reply to CaseyInsights]

Thank you for these links Great reading!

[Bolt_Upright]

You can see my stack here (I need to update it so show 1000 mg of Mireva curcumin twice a day): rbd-pd-protocols.blogspot.c...

[JayPwP in reply to Bolt_Upright]

Thanks

[Bolt_Upright]

I have concerns about Ashwagandha. I think it is a super antigen (boosts your immune system) and I think PD is an autoimmune disease. Not a good combination (in my opinion). I wrote about it: What I've learned about Ashwagandha healthunlocked.com/cure-par...

[Sydney75 in reply to Bolt_Upright]

In an earlier post this week "ways to increase dopamine" ashwaganda was listed as may reduce dopamine but protects dopamine neurons and levels from stress. I was surprised at some of the supplements on the list that reportedly decrease dopamine. DHEA, GABA, Berberine, Magnoia, Vitamin C? and magnesium which is been reported to be very beneficial. It gets very confusing, I just don't want to give my HWP the wrong supplements thinking I am doing the right thing. For instance for magnesium the link is to PUBMED citing a study that "magnesium ion augmentation of inhibitory effects of adenosine on dopamine release in the rat striatum" Yeah right whatever that means.

[JayPwP in reply to Sydney75]

healthunlocked.com/cure-par...

[JayPwP in reply to Bolt_Upright]

It's too confusing 😂

[Despe in reply to Bolt_Upright]

I have to disagree with you, Bolt. Ashwagandha is a good supplement for PwP, according to my compounding pharmacist.

[JayPwP in reply to Despe]

ncbi.nlm.nih.gov/pmc/articl...

A good read

[JayPwP]

Updated MCT oil and Omega 3 DHA in the list

[JustJeff]

Posted a few weeks ago with Gingko Biloba top of the list

Parkinsons supplements

[JayPwP in reply to JustJeff]

Thanks. I have gone through your post earlier.

[beehive23]

your kidneys and or liver still need to process all that...

hang tough.....

[JayPwP in reply to beehive23]

Thanks. I also do a series of Pranayam and deep breathing exercises hoping that it will help my body and brain to recover or minimise the damage from the onslaught of medicines and nutraceutical chemicals.

[Despe]

Recycle. Take a break on weekends. If you follow Ambroxol's trial, 75mg is not enough.

[JayPwP in reply to Despe]

Thanks. 75 mg is the capsule strength. I will have to take 8 caps for 600 mg a day instead of 20 tabs of 30 mg each

Discussed here

healthunlocked.com/cure-par...

[Despe in reply to JayPwP]

I order hubby's Ambroxol on Amazon.de. Capsules are 75mg ea and he takes four in the morning and four in the evening.

amazon.de/s?k=ambroxol+75+r...

[dangilio in reply to Despe]

hi despe, i check the link but i can't find any ambroxol avaible. where do you buy it besides amazon?

[Despe in reply to dangilio]

Dangilio,

That is the only place I find it, Amazon.de.com.

[Despe in reply to dangilio]

If you have a US Amazon account, you may use the same credentials to sign in to the German Amazon.