4 amazing videos that change the way we look at Parkinson's.

[parkinsonshereandnow]

"The real voyage of discovery consists,

not in seeking new landscapes, but in having new eyes."

Marcel Proust

Over the last 40 years, four courageous and compassionate neurologists have investigated the use of various substances to achieve a "miraculous" improvement in patients with many years of dignosticised disease and many years of levodopa-carbidopa plus other drugs (severe iatrogenic or treatment damage added to the original Parkinson's).

It is wonderful and fascinating to see how these substances are able to "revive" people whose bodies seem to have surrendered to oxidation, inflammation, loss of energy due to malfunctioning of the mitochondria, damage caused by treatments (iatrogenesis often worse than the original disease itself) and a long etcetera of possible causes.

I am reminded of a morning in 2010 when my father, for no known reason or cause, got up from his armchair as if he did not have Parkinson's, neither in the expression on his face, which looked as it had 25 years ago, radiant with happiness, nor in his movements, perfectly coordinated and full of energy. Only to "switch off" after a few minutes and return to his Parkinson's after 16 years of diagnosis and 10 years of levodopa-benserazide and pramipexole.

I am not going to give up because I know, I intuit (intuition is a shortcut to knowledge) that we have missed many important things waiting in digital databases such as Medline and in old books (Werbach, Pfeiffer, Wurtman, Pischinger, Reckeweg, Seignalet, Birkmayer, Knoll...).

1) BIRKMAYER - NADH (VITAMIN B3 COENZYME).

In the video we can see the neurologist Walther Birkmayer, pioneer of levodopa, after administering parenterally (intravenous infusion, but drop by drop) the vitamin B3 coenzyme NADH, essential in cellular respiration and in the energy of the mitochondria, the cell's energy factories. It also stimulates the natural production of dopamine.

youtube.com/watch?v=e2dPS8c...(Not working as expected?)

2) PERLMUTTER - GLUTATHIONE.

In this one, the famous neurologist David Perlmutter accompanies several patients after administering parenteral glutathione and observing how they start to move in a surprising way. Although no such benefits were found in a later study (Hauser 2009), we now suspect that it could be because Perlmutter administered significant amounts of B vitamins to his patients before and during the tests (B1, B2, B3...).

Monti in 2019 has obtained similar results with the administration of NAC (N-acetylcysteine) orally and parenterally.

youtube.com/watch?v=wxno30s...(Not working as expected?)

3) COIMBRA - RIBOFLAVIN (VITAMIN B2).

One of the patients of the Brazilian neurologist Cicero Galli Coimbra who received in 2003 moderately high doses of riboflavin or B2 (30-30-30 mg daily) and at 6 months had achieved an average motor improvement of 44 to 71 %, with three of the 19 patients scoring 100 % according to the UPDRS scale.

The interview was conducted at three months, so the improvement continued after the video was made.

youtube.com/watch?v=TTSOHBD...(Not working as expected?)

4) COSTANTINI - THIAMINE (VITAMIN B1).

And finally, at least since 2013 the use of vitamin B1 by the Italian neurologist Antonio Costantini, recently deceased (May 2020). Vitamin B1 is vital for numerous brain processes, such as the synthesis of neurotransmitters, antioxidant mechanisms, etc. It has been known since the 1960s that B1 deficiency leads to a deficit in dopamine synthesis (Linèt 1967) and its restoration to an increase (Yamashita 1993). Luong and Nguyen already established this in 2012. Smithline clarified many doubts in his study on how it works in the body in 2012: in high oral doses, blood concentrations similar to the intramuscular and intravenous routes are reached.

The therapy produced a significant improvement in motor function measured with the UPDRS scale between 31.3% and 77.3% (Costantini 2013, 2016).

Alberto was the first patient to see the immense improvement of intravenous benfotiamine therapy, a form of vitamin B1.

before starting:

youtube.com/watch?v=AUjaLjT...(Not working as expected?)

2 weeks of therapy:

youtube.com/watch?v=CFeFIj-...(Not working as expected?)

two years of therapy:

youtube.com/watch?v=k6jyuCR...(Not working as expected?)

---

For the first time in history, a patient can take control of his or her Parkinson's disease under the essential supervision of a neurologist and pharmacist. And to cope with the disease without the terrible side effects of only symptomatic drugs. It is now possible to prevent it, slow it down and control the symptoms (vitamins B1, B2, B3, B6, B9, B12, C, D3, magnesium, zinc, selenium, melatonin, resveratrol...).

The good news is that all substances are now available by liposomal and sublingual routes. In addition, there is the possibility with specific forms or powerful oral doses to bypass the body's mechanisms for limiting the absorption of certain substances (digestive tract, protective barrier of the brain).

1) Nicotidamide is better than niacin. Sublingual NADH.

2) N-acetylcysteine amide (NAC a), a precursor of cysteine (the hard-to-get part of glutathione) and able to cross the protective brain barrier without problems, as well as reaching neurons from astrocytes using glutamate transporters in the neuronal membrane (Aoyama 2011).

3) Oral doses of thiamine hydrochloride of 1.5 to 2 grams increase uptake to levels similar to the intramuscular and parenteral routes (Smithline 2012).

Two aspects are observed in the use of natural substances in high or very high doses (always under medical supervision):

- When a nutrient is used in very high doses, it must be accompanied in parallel by an increase in its cofactors. This is well known with the various B vitamins among themselves and with magnesium;

- The use of very high doses can bypass the body's mechanisms for limiting their oral assimilation. This also occurs when these high doses are repeated several times. For example, the 2000 mcg dose of B12 is effective even if there is no intrinsic factor in the stomach (Albadal 2005); the 1500 mg dose of thiamine hydroxyclohydrate reaches concentrations similar to the intramuscular route (Smithline 2012); until 2004 it was believed that the maximum concentration of vitamin C in the blood by the oral route was 80 micromoles per litre, and in 2004, studies by Polidori and Padayatti found that it could be three times as high; etc.).

And a question: why has no one tried using B1, B2, NADH and NAC amide in perhaps lower doses but adding or pooling the benefits of all the substances? Is it crazy to think that it would bring about a revolution in the world of Parkinson's?

(by Jesus Marquez Rivera. Parkinsons here and now)

[park_bear]

N-acetylcysteine amide is available from chemical suppliers at hundreds of dollars for tens of milligrams. Not exactly a therapeutic option.

[parkinsonshereandnow in reply to park_bear]

Thanks for your comment, park_bear. Then NAC orally, intravenously and nasally (with nebuliser as for asthma, COPD...). Or any way to raise the glutathione level (undenatured whey, alpha lipoic acid, turmeric, milk thistle, selenium, vitamin C, etc.).

[park_bear in reply to parkinsonshereandnow]

I do take NAC orally, 600 mg 3 times daily. As far as I can tell it has not helped my PD. I take it for other reasons.

For a while I tried nebulized glutathione, which likewise had no effect.

[Oceanwind]

Thanks for your post. I will save this for future reference because it is very informative! Are you a researcher? Are you a PWP?

[parkinsonshereandnow in reply to Oceanwind]

Thanks to you, Oceanwind. I took care of my father until he passed away in 2012. I promised him that I would help patients and relatives and since then I search and spread what I find. I have a blog in Spanish and English since summer 2012, with free books and booklets (Parkinson's here and now).

[chartist]

These are some of the supplements that are used frequently on this forum or discussed at length along with others such as mucuna pruriens, vinpocetine, very low dose lithium orotate and mannitol with multiple supplements that boost glutathione such as melatonin which also reduces neuroinflammation and elevated oxidative stress levels in the body and brain. More recently a broccoli seeds/sulforaphane protocol is under testing. While Dr. Costantini was still alive, he communicated often with this forum and had multiple patients here.

All require testing because of individual variations in PwP as far as results/benefits. What has shown one benefit for one person may show multiple benefits in another person or no benefits at all. Overall, what you have mentioned are among some of the better ones discussed on this forum.

Art

[parkinsonshereandnow in reply to chartist]

I am thrilled with the quality and variety of this forum. Until now I only found the information I needed in books, studies (PubMed) and some blogs.

The 58 questions to Dr. Costantini and colleagues seem to me to be a model to follow in order to provide the majority of patients and their families with everything they need to know about a supplement.

I am learning a lot here.

And I want to share with the community some of the things I have found in the last 8 years.

[LAJ12345]

My husband is taking all of these!

[Hidden]

What an excellent post. I have learned so much. I am so grateful for your advocating as a legacy to your father. What a wonderful son you are.

[Hidden]

I tried to find your blog. May I have the address? Is it blogger?

[parkinsonshereandnow in reply to Hidden]

Thank you very much, cclemmonade.

The blog is parkinsonhereandnow.blogspo...