Reading about the B1 therapy of Doc Constantini also on this forum, I ask myself (and to everybody) if the others B vitamins (in addition to B1), involved in Krebs Cycle (see pic - vit. B1, B2, B3 and B5) may have a similar/sinergic effect on Parkinson Disease.
Any ideas/info/experience/prospective on this?
I don't even know if Costantini ever tried.
Many thanks in advance
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Somic67
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You must consider that current knowledge of cell chemistry is very poor. We tend to treat the human body as a kind of test tube where adding or removing chemicals can duplicate the function of cellular life. But there is life in the cell that meant intelligence, purpose, adequate structure and direction. IMO we are in the prehistory of biology.
add a good dose of minerals and you will still have some benefits, possibly from fresh fruit and vegetables because I don't know of a good quality multimineral supplement. Maybe someone else can help us.
Of course Gioc - trace minerals are ‘on the daily menu’ along with papaya or pineapple. Coconut water - major source of electrolytes - is on the menu almost every day.
Magnesium supplement - Calm - along with probiotics and prebiotics and a touch of apple cider vinegar starts of the Monday to Friday routine.✌🏾
do you take a vit B complex supplement? if yes, is it high potency or std one (eventually the name?)
re multimineral: have you ever heard of Quinton Marine Plasma and "isotonic" sea water (or made by raw sea salt) as multi-mineral supplement (and for gut health)?
Pros: natural, very cheap (approx 4€ for 2 Lt usefull for 20 "drinks"), with full mineral spectrum at a concentration that is very close to the blood plasma. it has many uses (drinking as isotonic water (just add 3 parts of pure water), clean theets, if isotonic regulate gut and digstion, pure used to cause diarrhea, mineralization and last but not list, cooking (mainly fish but not only)
Cons: must be food grade, not easy to find
hope this helps. lt me know if you have more questions.
Gioc, personally use dr Mercola B complex, as well the rest of his organic, some biodynamic supplements : minerals, enzymes, D3&K2; C and the rest of his vitamins, here his site
I personally use B complex from dr Mercola, as well of the rest of his organic, some biodynamic supplements, including minerals, electrolytes, enzymes, D3, C and so on
I am taking all 8 B vitamins early in the AM. This makes a big difference. In a few minutes after taking them I feel relaxed, no tremor, no stiffness for a few hours. This allows me to postpone the first dose of Carb/Levo/Ent until10 AM being symptoms free.
BTW, Pyridoxal-5-Phosphate is the good kind of B6 supplement. At higher doses, you're less likely to have trouble with it in comparison to pyridoxine, which is the more common form of b6 supplement.
Hi Somic67 ! It was a trial and error approach. First I tried to take a higher doze of B6. It was 6 mg originally, but I couldn't tolerate that much, so I gradually tuned it down to 2 mg. You may have a better tolerance towards B6. I used the same approach with the rest of the vitamins. BTW, B6 dose is in mg, 1000 mcg = 1 mg (just in case you didn't take this into account).
yes, i agree. it seems a well ponderated mix. I'm wondering (actually investigating) at which level B6 can be increased without much interfering with carbidopa.
C/B6 = 1/1 didn't work for me (my current C/L ratio "was" approx. 1/20 for approx 1000/1200 mg LD in 16 hrs; then stop for 8 hrs) I had to increase (duplicate) carbidopa as therapy lost effectiveness and this makes no sense to me.
So I'm looking for another C / B6 ratio to get both benefits. I know that emivita of B6 is much longer than of C (15 days vs 15 hours), therefore this may indicate that B6 can be less than C and still have a meaningful result.
Hi GioCas, please tell me more about your experience with Niacin and which form you are taking. I added it recently and so far it didn't give me any problem. I am a bit concerned about its effect on the methylation process.
Hello Somic67 ~ I know you didn't ask for my input, but I thought I'd let you know the B Complex that we take and have been for a few years now. We (husband is the PwP) take Thorne Basic B complex. I am only mentioning this because we saw 2 different ND's that said it was a "good" one. I buy it from Amazon.
he tried........ i was one of the last contacts......krebs cycle.....how many NADH's does it take to make one ATP?........................sorry im a scientist................cheers nice citric acid cycle diagram thank you! the IM self injections are brutal for me but it definatly reduces symptoms imo. i have been approved for sub-q apomorhine for breakout suffocation issues.....
I take forms of B1, B6, B9, and B12. Haven't given much thought to 2, 3, or 5. (I was taking an expensive form B3 for awhile but I couldn't afford to keep taking that.)
I do think some caution is merited. There are correlation studies that do find some adverse health outcomes related to high doses of some B vitamins.
There was a study that found women who take high doses of B6, B12, or both, had some negative outcome (maybe something to do with bones? I'd have to find the article).
The most common form of B6 supplement is not the active form. Taken in high doses, it may actually compete with the active form of B6 and cause symptoms that are similar to B6 deficiency.
B9 can be good for you, and a deficiency is definitely bad. B9 is a supplement that can lower homocysteine (sp?) levels. This is pertinent to people with Parkinson's, because Levodopa can raise homocysteine levels, and high levels of homocysteine are connected to higher risks of getting heart disease and dementia. HOWEVER, higher levels of B9 were found in one study to be associated with a greater risk of colon cancer in some instances. (Basically they thought that if you have proto-tumors, B9 helps them grow faster.) As with other B vitamins, B9 comes in more than one form.
Hi, I‘m taking Nicotinamid-Ribosid (B3), because it showed good results in studies with mices (University of Tübingen), since 2 years, and I‘m feeling pretty fine, even augmented my 70%-job to 100 %... PD disgnosed 2013, also taking nicotin-chewing gums and Madopar.
Dear ElliotGreen, yes, it‘s about this study. I‘m taking 600mg daily. And you‘re right, it‘s quite expensive! But it‘s this Niagen they used for the studies in Tübingen...kind regards, Danielle
Hi Sonic67, I read from studies about nicotine preventing PD, so I started chewing gums. No idea whether it helps, but especially when my Madopars efficiency comes to an end and I get some kind of Dyskinesia, it helps. Or at least I believe it helps. And believing itself is helping, as we all know, don‘t we? 😀
After Dr. Constantini died I decided to try the B1 treatment myself. I want to believe his findings that it helps with constipation ( I am NEVER constipated) but most of all I want help with saliva problems at night. I have no problems during the day but around 4 am am woken up with terrible problems re the consistency and volume of "stuff" that will not be swallowed. I love my bed (I am 76 and have always slept well but not any more). I have now added B12 to my regime as it is supposed to guard against dementia! I will post my results.
I personally use dr Mercola B complex, as well the rest of his organic, some biodynamic supplements : minerals, enzymes, D3&K2; C and the rest of his vitamins, here his site I personally use B complex from dr Mercola, as well of the rest of his organic, some biodynamic supplements, including minerals, electrolytes, enzymes, D3, C and so on, here his site
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