Hi, I’m new and I’m hopi g you can offer some advice and help interpreting these results.
I’m 44F and generally healthy but have been struggling with what I thought were perimenopause symptoms. Heavy periods, cystic acne, anxiety and depression, fatigue, joint and muscle pain and weight gain. In addition I have had dry skin, constipation, cold intolerance and hair thinning for a number of years. I’ve had blood tests a few times over the last 3 years and they came back normal until now. After these results the gp wants to see me and wants me to be checked for antibodies. I have an appointment next week but in the mean time would really appreciate your thoughts and advice interpreting these results and figuring out what I need to ask the gp. I include only the ‘abnormal’ results below.
Your GP is testing TPO & TG antibodies to check if you have an autoimmune condition damaging your thyroid. Most hypothyroidism is cause by this, (known as autoimmune thyroiditis or Hashimoto’s) but all hypothyroidism what ever the cause is treated the same.
Your results show you are very hypothyroid. The TSH is a pituitary hormone & It signals the thyroid to lower or increase production. Most have a TSH around 1. at 10 it is considered overt & yours is very high.
Symptoms are caused by low thyroid hormones (FT4 & FT3) not the TSH & your FT4 is currently under range. There’s no question you will need replacement thyroxine (this is called levothyoxine or LT4).
Usual starting dose is 50mcg, sometimes doctors can start on a higher dose using a calculation of 1.6mcg Levo per 1kg body weight, but some find it a shock to the system.
You might want to start on a 50mcg but increase at a gradual pace. Often this is 6 weekly - retesting and increase by 25mcg per day after each test. If you tolerate increases well you can push for faster / greater dose increase.
What shouldn’t happen is doctor says here’s a 25mcg starting dose we’ll check you again in a few months.
Cholesterol is high but this is caused by low thyroid levels, once you are replaced adequately this should improve. Should the doctor suggest treating the cholesterol there are references advising treatment should be delayed until thyroid treated.
Nutrients are often low when hypothyroid. As stomach acid is often low and absorption is affected. Was folate & B12 tested?
Ask to be tested for gluten allergy as this is common with thyroid autoimmune.
Nutrients need to be optimal for Levo to work well, not just anywhere in range.
Your iron & vitamin D are also very low & you’ll need supplements. Doctor should prescribe this, but often NHS treatment are insufficient dose to improve a deficiency and doctors do not also recheck after course prescribed. It might be something you’ll need to monitor and supplement yourself.
There is another thyroid hormone called FT3 (free Triiodothyronine) this is the active thyroid hormone. NHS do not often tests it, but many test privately to ensure T4 is converting to T3.
At this stage starting on replacement & improving nutrient level is the main aim.
Recommended that future tests should be arranged for first thing in morning, fast overnight & delay levo dose until after draw. This shows the highest TSH & Lowest FT4.
If you take any supplements containing biotin you should stop it 3 days before test there potential for biotin to skew the testing process.
Read lots of posts on here & information from thyroiduk.org this will help you learn how doctor is treating you & you can track & guide treatment to what’s is best for you.
Folate is too low, look at taking a B complex with methylfolate. (Not folic acid which is synthetic)
Hypothyroid can contribute to anaemia (hypo can cause the heavy periods).
As you been anemic for a long time has doctor thought to refer you?
Almost certainly autoimmune - Over 90% of hypo due to autoimmune (even on occasions when antibodies are not positive, an ultrasound scan confirms autoimmune damage)
Rarer causes are:
- congenital mal-development of thyroid (which is detected at birth)
- a pituitary issue (your TSH is responding as expected)
- Severe iodine deficiency (exceptionally rare in UK)
- Several specific Medications causing complications (patients are warned of potential)
- previous radioactive treatment (for either cancer / overactive thyroid)
As you have a long-standing history of anaemia and significantly low iron levels despite supplementation, I would personally see an iron specialist for further advice. I can pass on info if you want to go down that route. The key tests are ferritin and transferrin saturation %. Mine was 18%, which was a significant deficiency.
You may still be B12 deficient or have pernicious anaemia regardless of test results. Tests for these are a good idea before supplementing, if only to rule this out.
Anaemia that doesn’t respond to iron supplement should be further investigated by haematologist. I think GPs focus on haemoglobin levels. Unless this is low they’ll just keep prescribing iron, but not question why it not resolving the issue.
I feel you should be starting levothyroxine immediately with a TSH that high and T4 so low. Your Dr needs to act swiftly. You could do witn some Ferris Fumetate for your low ferritin and vit D supplement too. Often people with thyroid conditions have low vitamin levels. You must be feeling pretty bad. Your symptoms remind me of mine when my GP refused to check my thyroid bloods when I was in my early 40’s. He kept saying i was depressed when I wasn’t I was in lots of pain and symptoms you’re describing. after ages they agreed and my TSH was 36. I was prescribed levothyroxine immediately 100mcg a day. Remember not to take iron meds close to levothyroxine med. take iron at least 4 hours after as they are contraindicated. If T4 levothyroxine doesn’t relieve your symptoms get your T3 checked also. Levo T4 sits in your body waiting to be converted to the most important hormone T3. Lots of people have trouble converting T4 levo to T3. With low T3 you will always struggle. One step at a time though for now. I do hope you get the levothyroxine quickly and importantly start feeling better soon which may take a few months.
Thank you for the advice and for sharing your experience too. I do feel really awful, I have done for a while. Sad thing is I saw it as a personal failing that I couldn’t function the way I thought I should be able to.I really hope the medication will help and that it doesn’t take too long.
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Doctors order a new blood test. 
Results help please
Back with test results, please advise!
Blood test results in full. Can anyone find a cause in there for my continued fatigue etc?
