results and now not sure where I am .. central hypothyroidism?

[lauriegraham]

hello, i posted before, low t3, and 4 and also tsh lowish, high ldl, low ferritin, new to all this. It was suggested i get more tests eg cortisol etc , My initial post is here healthunlocked.com/thyroidu...

@slowdragon and @jimh111 both gave helpful responses then

below are a large range of new results but i have posted cortisol, thyroid and ferritin /iron first, not sure of relevance of others

a few suggested possible central hypothyroidism and i am guessing this might fit the picture? if so, or not, any advice on next steps gratefully received

cortisol .. this seems low ..

Cortisol AM30 11 nmol/L 14.0 – 25.0 (optimal) 7.0 – 30.0 (reference)

Cortisol Noon 6.2 nmol/ L 5.0 – 10.0 2.1 – 14.0

Cortisol Evening 3.2 nmol/ L 2.0 – 5.0 1.5 – 8.0

Cortisol Night 4.2 nmol/ L 1.0 – 4.0 0.33 – 7.0

DHEA* 25 pg/mL 137 – 336TSH 1.90 mIU/L 0.27 - 4.20 m0.27 - 4.20 mIU/L

Free t4 12.3 pmol/L 12.0 - 22.0 pmol/L12.0 - 22.0 pmol/L

Thyroid Peroxidase Abs (TPO)Your Value<9 IU/mLStandard Range0 - 34 IU/mL

Free T3Your Value3.6 pmol/LStandard Range4.0 - 6.8 pmol/L

Thyroid Peroxidase Abs (TPO)Your Value<9 IU/mLStandard Range0 - 34 IU/mL

25-hydroxy Vitamin D (total)Your Value180 nmol/LStandard Range25 - 120 nmol/L

IronYour Value20.2 umol/LStandard Range10.6 - 28.3 umol/

LUnsaturated iron bindingYour Value45.2 umol/LStandard Range20 - 66 umol/

LTotal iron binding capacityYour Value65 umol/LStandard Range41 - 77 umol/L

Ferritin 56 30-400g/L

Sex hormone binding globulinYour Value67 nmol/LStandard Range19 - 83 nmol/L

TestosteroneYour Value22.7 nmol/LStandard Range7.6 - 31.4 nmol/L

SodiumYour Value138 mmol/LStandard Range135 - 145 mmol/L

PotassiumYour Value4.7 mmol/LStandard Range3.5 - 5.1 mmol/L

CreatinineYour Value109 umol/LStandard Range66 - 112 umol/L

Estimated GFRYour Value62 .Standard Range

ProlactinYour Value182 mIU/LStandard Range86 - 324 mIU/L

Luteinising hormoneYour Value7.5 IU/LStandard Range1.7 - 8.6 IU/L

Growth hormoneYour Value4.0 ug/LStandard Rangeug/L

Follicle stimulating hormoneYour Value10.2 IU/LStandard Range1.5 - 12.4 IU/L

CortisolYour Value274 nmol/lStandard Rangenmol/l

Reference range 6-10 am: 133 - 537 nmol/L

Insulin-like growth factor 1Your Value19.2 nmol/LStandard Range3.5 - 32.0 nmol/L

Liver

Bilirubin (total)Your Value7 umol/LStandard Range0 - 20 umol/L

Alkaline phosphataseYour Value66 IU/LStandard Range40 - 129 IU/L

Alanine transaminaseYour Value15 IU/LStandard Range10 - 50 IU/L

AlbuminYour Value46 g/LStandard Range34 - 50 g/L

Haemoglobin A1c (%)Your Value5.4 % total HbStandard Range4.0 - 6.0 % total Hb

Haemoglobin A1c (mmol/mol)Your Value35 mmol/molStandard Range20 - 42 mmol/mol

CholesterolYour Value9.2 mmol/LStandard Range2.5 - 5.0 mmol/L

Cholesterol > 8 mmol/L. If secondary causes

TriglycerideYour Value0.5 mmol/LStandard Range0.4 - 2.3 mmol/L

HDL CholesterolYour Value2.3 mmol/LStandard Range0.9 - 1.5 mmol/L

Non-HDL CholesterolYour Value6.9 mmol/LStandard Rangemmol/L

LDL Cholesterol (Calculated)Your Value6.7 mmol/LStandard Range0 - 3.5 mmol/L

Cholesterol:HDL ratioYour Value4.0

Creatine kinase 125 IU/L 38 - 204 IU/L

Glucose 5.7 3.9 to 5.8

Haemoglobin a1c 5.4 4-6

Haemoglobin a1c 35 mmol/mol 20-42

[SlowDragon Administrator]

TSH 1.90 (0.27 - 4.20)

Free t4 12.3 (12.0 - 22.0)

Thyroid Peroxidase Abs (TPO)9

Free T3 3.6 (4.0 - 6.8)

Vitamin D 180

Iron 20.2. (10.6 - 28.3)

Ferritin 56 (30-400g/)

Estimated GFR 62

Who did these tests Ft3 range isn’t Medichecks or Blue horizon

Ft4 is obviously very very low

Ferritin low for a chap

No folate or B12

No thyroglobulin antibodies tested

GFR looks low. Hypothyroidism can cause low GFR

High cholesterol linked to being hypothyroid

Looking like central hypothyroidism

Hidden may pop along and comment on cortisol and DHEA

[lauriegraham in reply to SlowDragon]

Thanks. @slowdragon Cortisol via regenerus, rest via nhs Grateful for any popping along !

[SlowDragon Administrator in reply to lauriegraham]

Ft4 is only 3% through range

Ft3 is BELOW RANGE

High cholesterol and hypothyroidism

nhs.uk/conditions/statins/c...

If you have an underactive thyroid (hypothyroidism), treatment may be delayed until this problem is treated. This is because having an underactive thyroid can lead to an increased cholesterol level, and treating hypothyroidism may cause your cholesterol level to decrease, without the need for statins. Statins are also more likely to cause muscle damage in people with an underactive thyroid.

Low GFR and hypothyroidism

journals.lww.com/md-journal...

What’s your diet like

Are you vegetarian or vegan?

Suggest you see adrenal pituitary and thyroid specialist endocrinologist

Roughly where in the U.K. are you

Email Thyroid UK for list of recommend thyroid specialist endocrinologists...

NHS and Private

[e-mail]

[lauriegraham in reply to SlowDragon]

Thanks. I am in London. I eat a good diet, lowish carb, no processed food, a good amount of iron rich animal products. Re endo, Do I contact someone backhanded to get suggestions?

Also what is significance of such low dhea anyone?

Thanks again

[SlowDragon Administrator in reply to lauriegraham]

There’s number of endocrinologists on that list in London

You can put up a post asking members about a particular doctor, by private message

Low DHEA suggests adrenals are struggling

Could be thyroid related or pituitary related

mayoclinic.org/diseases-con...