Experiences with
Addison's diseaseSymptoms of Addison's disease
Early-stage symptoms of Addison's disease are similar to other more common health conditions, such as clinical depression or flu.
You may experience:
- lack of energy or motivation (fatigue)
- muscle weakness
- low mood
- loss of appetite and unintentional weight loss
- increased thirst
Over time, these problems may become more severe and you may experience further symptoms, such as dizziness, fainting, cramps and exhaustion.
You may also develop small areas of darkened skin, or darkened lips or gums.
Although these symptoms are not always caused by Addison's disease, you should see a GP so they can be investigated.
Why it happens
Addison's disease is usually the result of a problem with the immune system, which causes it to attack the outer layer of the adrenal gland (the adrenal cortex), disrupting the production of the steroid hormones aldosterone and cortisol.
It's not clear why this happens, but it's responsible for 70% to 90% of cases in the UK.
Other potential causes include conditions that can damage the adrenal glands, such as tuberculosis (TB), although this is uncommon in the UK.
Treating Addison's disease
Addison's disease is treated with medicine to replace the missing hormones. You'll need to take it for the rest of your life.
With treatment, symptoms of Addison's disease can largely be controlled. Most people with the condition have a normal lifespan and are able to live an active life with few limitations.
But many people with Addison's disease also find they must learn to manage bouts of fatigue, and there may be associated health conditions, such as diabetes or an underactive thyroid (hypothyroidism).
Adrenal crisis
People with Addison's disease must be constantly aware of the risk of a sudden worsening of symptoms, called an adrenal crisis.
This can happen when the levels of cortisol in your body fall significantly.
An adrenal crisis is a medical emergency. If left untreated, it can be fatal.
If you or someone you know has Addison's disease and is experiencing severe symptoms, they will need a hydrocortisone injection immediately, either injected by themselves or by a person who is with them.
Then call 999 for an ambulance, saying it's an "adrenal crisis" or "Addisonian crisis".
SymptomsCausesMedical treatmentsEarly symptoms of Addison's disease include lack of energy, weakness, increased thirst and a low mood. The symptoms can get gradually worse over time.
Addison's disease is usually caused by a problem with your immune system.
Treatment for Addison's disease usually involves taking hormones to replace the ones not produced by your adrenal glands.
Related links
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