New here, can someone help with my results please.

[vinnieboy]

Hi

I am new here, I have been looking at a lot of posts for a while now but this is my first post.

I was diagnosed hypo a few years ago and take 125mcg. levothyroxine.

I had problems getting my dose increased, but have felt pretty settled on 125mcg. until recently. Feeling more tired, headaches, aches and pains, really bad indigestion, anxious and feeling a bit low.

I decided to get some private blood tests and find although my thyroid levels look O.K. some other levels are out of range.

Could anyone offer advice please.

Many thanks.

Advanced iron profile

ALL RESULTS NORMAL

Total iron-binding capacity (TIBC)

Result 66 umol/L

Normal

Range 41 - 77

Unsaturated iron binding capacity (UIBC)

Result 41.8 umol/L

Normal

Range 24.2 - 70.1

Ferritin

Result 88 ug/L

Range 13 - 150

Iron

Result 24.2 umol/L

Normal

Range 5.8 - 34.5

Transferrin saturation

Result 37%

Normal

Range 20 - 45

Thyroid advanced profile

Triiodothyronine (FT3)

Result 5.2 pmol/L

Normal

Range 3.1 - 6.8

Thyroid-stimulating hormone (TSH)

There wasn’t enough blood for the lab to process

Thyroglobulin antibodies (TgAB)

There wasn’t enough blood for the lab to process

Thyroid peroxidase antibodies (TPOAb)

Result 18.4 kIU/L

Range 0 - 34

Thyroxine (T4)

Result 103 nmol/L

Normal

Range 66 - 181

Free thyroxine (FT4)

Result 21.1 pmol/L

Normal

Range 12 - 22

Vitamin B12 (Active)

Active B12

Result 73 pmol/L

Normal

Range 37.5 - 188

SOME ABNORMAL RESULTS

Total B12

Result 296 pmol/L

Under range

Range 300 - 569

Folate

Result 7.5 nmol/L

Under range

Range 8.83 - 60.8

Cholesterol (Lipid profile)

SOME ABNORMAL RESULTS

Triglyceride/HDL ratio

Result 1.32:1 Ratio

Normal

Ratio 0 - 1.75

LDL cholesterol

Result 4.2 mmol/L

High

Range 0 - 34

Non-HDL Cholesterol

Result 5.15 mmol/L

High

Range 0 - 4

HDL cholesterol

Result 1.65 mmol/L

Optimal

Range 1.3 - 3.88

Cholesterol

Result 6.8 mmol/L

High

Range 0 - 5.2

HDL/Total cholesterol ratio

Result 24%

Normal

Ratio 20 - 100

See details

Triglycerides

Result 2.17 mmol/L

Abnormal

Range 0 - 2

Liver function

SOME ABNORMAL RESULTS

Gamma-GT

Result 56 IU/L

High

Range 0 - 42

Alanine transferase

Result 44 IU/L

High

Range 10 - 35

Albumin

Result 43 g/L

Normal

Range 34 - 52

Alkaline phosphatase

Result 102 IU/L

Normal

Range 0 - 130

Globulin

Result 29 g/L

Normal

Range 19 - 35

Bilirubin

Result 11 umol/L

Optimal

Range 0 - 15

Total protein

Result 72 g/L

Normal

Range 63 - 87

Vitamin D

SOME ABNORMAL RESULTS

Vitamin D

Result 49 nmol/L

Insufficient

Range 50 - 175

[SlowDragon Administrator]

Vitamin D 49 nmol/L Range 50 - 175

Insufficient

Folate 7.5 nmol/L Range 8.83 - 60.8

Deficient

Total B12 296 pmol/L Range 300 - 569

Under range

If you read posts on here regularly, you will know these are too low and need improving by supplementing

What vitamin supplements are you currently taking?

Have you ever had high thyroid antibodies in past

Were thyroid tests done as early as possible in morning before eating or drinking anything other than water and last dose levothyroxine 24 hours before test

Do you always get same brand of levothyroxine

[vinnieboy in reply to SlowDragon]

Hi

thank you for your reply.

Yes I always get the same brand of levothyroxine, also did test 24 hours after last levo, and fasted.

I have not been taking any supplements.

Other anti body tests were borderline so not sure if I have hashimotos or not.

Which supplements should I supplement first.

[SlowDragon Administrator in reply to vinnieboy]

Only ever add one supplement at a time

Suggest you start with vitamin D (recommend getting Vitamin D with K2 included by Better you)

A few weeks after starting vitamin D supplements...consider adding magnesium.

All magnesium supplements must be four hours away from levothyroxine

A few weeks later consider adding daily vitamin B complex

Retest thyroid and vitamins again 6-8 weeks after adding last supplement

[SlowDragon Administrator in reply to vinnieboy]

Vitamin D

GP will often only prescribe to bring levels to 50nmol.

Some areas will prescribe to bring levels to 75nmol

leedsformulary.nhs.uk/docs/...

GP should advise on self supplementing if over 50nmol, but under 75nmol (but they rarely do)

mm.wirral.nhs.uk/document_u...

NHS Guidelines on dose vitamin D required

ouh.nhs.uk/osteoporosis/use...

But with Hashimoto’s, improving to around 80nmol or 100nmol by self supplementing may be better

ncbi.nlm.nih.gov/pubmed/218...

vitamindsociety.org/pdf/Vit...

Once you Improve level, very likely you will need on going maintenance dose to keep it there.

Test twice yearly via vitamindtest.org.uk

Vitamin D mouth spray by Better You is very effective as it avoids poor gut function. There’s a version made that also contains vitamin K2 Mk7

It’s trial and error what dose we need, with hashimoto’s we frequently need higher dose than average

Calculator for working out dose you may need to bring level to

40ng/ml = 100nmol

grassrootshealth.net/projec...

Government recommends everyone supplement October to April

gov.uk/government/news/phe-...

With your Vit D, are you also taking it's important cofactors - magnesium and Vit K2-MK7?

Magnesium best taken in the afternoon or evening, but must be four hours away from levothyroxine

betterbones.com/bone-nutrit...

medicalnewstoday.com/articl...

livescience.com/61866-magne...

sciencedaily.com/releases/2...

Vitamin K2 mk7

betterbones.com/bone-nutrit...

healthline.com/nutrition/vi...

Importance of vitamin D for fighting Covid

moxafrica.org/post/the-vita...

[SlowDragon Administrator in reply to vinnieboy]

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid) may be beneficial.

This can help keep all B vitamins in balance and will help improve B12 levels too

Difference between folate and folic acid

chriskresser.com/folate-vs-...

Many Hashimoto’s patients have MTHFR gene variation and can have trouble processing folic acid.

thyroidpharmacist.com/artic...

B vitamins best taken after breakfast

Igennus Super B is good quality and cheap vitamin B complex. Contains folate. Full dose is two tablets per day. Many/most people may only need one tablet per day. Certainly only start on one per day (or even half tablet per day for first couple of weeks)

Or Thorne Basic B or jarrow B-right are other options that contain folate, but both are large capsules

If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before any blood tests, as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

Low B12 symptoms

b12deficiency.info/signs-an...

With such low B12 result taking a B12 supplement and a B Complex (to balance all the B vitamins) initially for first 2-4 months, then once your serum B12 is over 500 (or Active B12 level has reached 70), stop the B12 and just carry on with the B Complex.

B12 sublingual lozenges

cytoplan.co.uk/vitamins/vit...

[vinnieboy in reply to SlowDragon]

Wow that's great.

Many thanks for all the information and the links, I will have a good read of them this evening.

Thank you also for the advice about the supplements. I will purchase them and take as you have suggested.

Best wishes to you.

[humanbean]

Triglycerides 2.17 mmol/L Range 0 - 2

Gamma-GT 56 IU/L Range 0 - 42

Alanine transferase 44 IU/L Range 10 - 35

Your high triglycerides and high GGT are most commonly caused by either a high carbohydrate and/or high sugar diet, or drinking too much alcohol (or both), and this may lead to liver disease. You might be developing one or more of the following :

NAFLD - en.wikipedia.org/wiki/Non-a...

Fatty liver disease - en.wikipedia.org/wiki/Fatty...

Alcoholic fatty liver disease - en.wikipedia.org/wiki/Alcoh...

Ideally your triglycerides should be under 1 and your GGT should probably be around mid-range or under.

Your high ALT is also suggesting that you are possibly in the process of getting a fatty liver or liver disease and reducing sugar and alcohol should help.

Personal anecdote... My own ALT is usually around mid-range. But a couple of years ago I got addicted to ice cream for a while. Next time I had a liver function test done my ALT was over the range and my triglycerides had shot up and were also over the range. I cut the ice cream down dramatically and re-tested a few months later and both ALT and triglycerides had improved back to being almost normal for me.

[vinnieboy in reply to humanbean]

Many thanks for your reply.

I was hoping the high results were connected to being hypothyroid, but I must admit I do enjoy too much wine and chocolate, so I will have to cut both right down and hope it brings the levels down.

Best wishes.

[humanbean in reply to vinnieboy]

Regarding your cholesterol, you might find the picture on this tweet of interest :

twitter.com/lowcarbGP/statu...

[vinnieboy in reply to humanbean]

Thank you.