Ameliej Any doctor that reduces dose of 150mcg Levo to just 25mcg Levo in one go is a sadist, not only that he hasn't got a clue about treating hypothyroidism and should be in a different job which doesn't involve people's health.
If I'm understanding correctly your doses at the time of the results -
Working from Aug 2015 with
TSH 1.21 (0.2 - 4.2)
Free T4 19.2 (12 - 22)
Free T3 4.1 (3.1 - 6.8)
Taking 175mcg levothyroxine
then on the strength of those results dose changed to 75mcg Levo plus 10mcg T3 - well the T3 was needed but that was a massive reduction in Levo, it should be done gradually not by 100mcg. On this dose you then have these results:
Free T4 20.5
Free T3 5.2
and your Levo was then increased to 100mcg plus 10mcg T3 because you still had symptoms and that increase produced these results:
Free T4 22.7
Free T3 4.6
so endo reduced your dose to 50mcg Levo only due to suppressed TSH and because he wanted you to start again with dose. I think that clearly showed he didn't know what he was doing. Your TSH was higher than in November, so less suppressed, and your FT3 lower than November, so you probably had the same, if not more, symptoms.
So this massive reduction then produced these results:
Free T4 13.8
Free T3 4.1
which clearly shows you were very hypothyroid so your endo gave you a massive increase to 150mcg levothyroxine and 10mcg T3 which then produced these results:
Free T4 18.2
Free T3 5.0 and the high TSH prompted an increase in Levo to 175mcg plus 10mcg T3 to give:
TSH 1.80 (0.2 - 4.2)
Free T4 15.7 (12 - 22)
Free T3 4.3 (3.1 - 6.8)
Yes, it reduced your TSH but your free Ts are a lot worse so he reduced your Levo again to 150mcg and removed T3 taken away "because endo didn't trust it". Was this a different endo? You had clearly shown a need for T3 so it should never have been removed. So this dose produced:
Sep 17 TSH 0.03 (0.2 - 4.2)
Free T4 20.9 (12 - 22)
Free T3 4.1 (3.1 - 6.8)
so now you have your Levo reduced to 25mcg due to suppressed TSH, which is actually higher than in Nov 2015 when TSH was <0.02 And now your measly 25mcg Levo has produced:
Oct 17 TSH 5.8 (0.2 - 4.2)
Free T4 13.9 (12 - 22)
Free T3 4.0 (3.1 - 6.8)
So what has now been said about your over range TSH and your low in range free Ts? What is your endo going to do now he has plunged you back into a hypo state again.
This endo is playing at pretending to know how to treat hypothyroidism, he will be a diabetes specialist who doesn't know much at all about thyroid disease. Run away as fast as you can. And if your GP has seen these results and hasn't intervened then run away from your GP too.
When TSH is suppressed as long as your FT3 is in range you can't be overmedicated. See thyroiduk.org.uk/tuk/about_... > Treatment Options:
According to the BMA's booklet, "Understanding Thyroid Disorders", many people do not feel
well unless their levels are at the bottom of the TSH range or below and at the top of the FT4 range or a little above.
The booklet is written by Dr Anthony Toft, past president of the British Thyroid Association and leading endocrinologist. It's published by the British Medical Association for patients. Avalable on Amazon and from pharmacies for £4.95 and might be worth buying to highlight the appropriate part and show your doctor. However, I don't know if this is in the current edition as it has been reprinted a few times.
Dr Toft states in Pulse Magazine, "The appropriate dose of levothyroxine is that which restores euthyroidism and serum TSH to the lower part of the reference range - 0.2-0.5mU/l.
In this case, free thyroxine is likely to be in the upper part of its reference range or even slightly elevated – 18-22pmol/l. Most patients will feel well in that circumstance.
But some need a higher dose of levothyroxine to suppress serum TSH and then the serum-free T4 concentration will be elevated at around 24-28pmol/l.
This 'exogenous subclinical hyperthyroidism' is not dangerous as long as serum T3 is unequivocally normal – that is, serum total around T3 1.7nmol/l (reference range 1.0-2.2nmol/l)."
You can obtain a copy of the article by emailing email@example.com print it and highlight question 6 to show your doctor.
So now you need to ask for an immediate increase in your Levo, it needs to be done gradually (as should decreases) so 25mcg now, retest in 6 weeks then another 25mcg increase, then repeat and repeat until FT4 and FT3 are at levels where you feel well and taking into account Dr Toft's comments if necessary.
Thyroid peroxidase antibodies 404.5 (<34)
Thyroglobulin antibodies 257.3 (<115)
Has anyone bothered to tell you that you have autoimmune thyroid disease aka Hashimoto's as confirmed by your high antibodies? This is where antibodies attack the thyroid and gradually destroy it. This will be one reason your results are jumping all over the place. Unfortunately, most doctors attach little or no importance to antibodies and don't understand what Hashi's does.
The antibody attacks cause fluctuations in symptoms and test results. When the antibodies attack, the dying cells dump a load of thyroid hormone into the blood and this can cause TSH to become suppressed and Free T4 and Free T3 to be very high or over range. These are called 'Hashi's flares' or 'swings'. You may get symptoms of being overmedicated (hyper type symptoms) to go along with these results that look as though you are overmedicated. Unless a doctor knows about Hashi's and these swings, then they panic and reduce or stop your thyroid meds.
The hyper swings are temporary, and eventually things go back to normal. Test results settle back down and hypo symptoms may return. Thyroid meds should then be adjusted again, increased until you are stable again.
Read, learn and educate yourself because you are going to have to help yourself here.
You can help reduce the antibodies by adopting a strict gluten free diet which has helped many members here. Gluten contains gliadin (a protein) which is thought to trigger autoimmune attacks so eliminating gluten can help reduce these attacks. You don't need to be gluten sensitive or have Coeliac disease for a gluten free diet to help.
Supplementing with selenium l-selenomethionine 200mcg daily can also help reduce the antibodies, as can keeping TSH suppressed.
Gluten/thyroid connection: chriskresser.com/the-gluten...
Hashi's and gut/absorption problems go hand in hand and very often the result is low nutrient levels.
Ferritin - Ferrous fumarate restarted Feb 2017 because of below range MCV iron infusion done May 2016
Oct 2017: 58
Jan 2017: 110.5 (15 - 150)
May 2016: 187
Jan 2016: 16 (15 - 150)
Nov 2015: 15 (15 - 150)
How much ferrous fumarate are you taking now? Are you being monitored by a haematologist?
For thyroid hormone to work (that's our own as well as replacement hormone) ferritin needs to be at least 70, preferably half way through range. You can help to raise and maintain your level by eating liver regularly, maximum 200g per week due to it's high Vit A content, and including lots of iron rich foods in your diet apjcn.nhri.org.tw/server/in...
Vit D - Vitamin D 3000iu started March 2015 but taking 800iu from 2013 Dec until then
Sept 2017: 65.3 (50 - 75 suboptimal)
Jan 2017: 70.5 (50 - 75 suboptimal)
Jan 2016: 72 (50 - 75 suboptimal)
Are you taking 3000iu daily now? Do you buy this yourself?
The Vit D Council recommends a level of 100-150nmol/L. You should really boost your level as it is still suboptimal. I would suggest that you take 5000iu daily for the next 3 months then retest, privately if necessary. If you haven't reached the recommended level then continue with 5000iu daily until you do, retesting after another 3 months. Once you've reached the recommended level then you'll need a maintenance dose and looking at your results it might be 3000iu daily, it's trial and error so it's recommended to retest once or twice a year to keep within the recommended range. You can do this with a private fingerprick blood spot test with City Assays vitamindtest.org.uk/
As you have Hashi's, for better absorption you should take an oral spray eg BetterYou which does a 3000iu dose so double that and take 6000iu daily until you reach the recommended level.
There are important cofactors needed when taking D3
D3 aids absorption of calcium from food and K2-MK7 directs the calcium to bones and teeth where it is needed and away from arteries and soft tissues where it can be deposited and cause problems.
D3 and K2 are fat soluble so should be taken with the fattiest meal of the day, D3 four hours away from thyroid meds.
Magnesium helps D3 to work and comes in different forms, check to see which would suit you best and as it's calming it's best taken in the evening, four hours away from thyroid meds
Check out the other cofactors too.
BetterYou do a combined D3/K2-MK-7 as well as D3 alone.
B12 injections started June 2017
In which case this is being looked after, but if you want any advice about B12 then the Pernicious Anaemia Society forum is the place to ask healthunlocked.com/pasoc
Folic acid prescribed Nov 2016
And it looks as though it is doing it's job. However, when supplementing B12 we need a good B Complex to balance ALL the B vitamins.
The absorption problems caused by Hashi's can be helped, check out SlowDragon's reply to this post which contains lots of information and links healthunlocked.com/thyroidu...