Hi to All,
My wife has now received her emailed results from Blue Horizon. I have her permission to post them here- in the hope that some experienced members may be able to help interpret?
Below are both the results and text summary from Blue Horizon. Many thanks in advance for any help with this.
CRP H 5.90 <5.0 mg/L
Ferritin 29.8 20 - 150 ug/L
TSH H 6.15 0.27 - 4.20 mIU/L
T4 Total 79.1 64.5 - 142.0 nmol/L
Free T4 12.80 12 - 22 pmol/L
Free T3 4.46 3.1 - 6.8 pmol/L
Anti-Thyroidperoxidase abs H 206.0 <34 kIU/L
Anti-Thyroglobulin Abs H 422 <115 kU/L
Vitamin D (25 OH) L 37 Deficient <25 nmol/L
Insufficient 25 - 50 Consider reducing dose >175
Vitamin B12 260 Deficient <140 pmol/L
Insufficient 140 - 250 Consider reducing dose >725
Serum Folate L 5.47 8.83 - 60.8 nmol/L
The Thyroid Stimulating Hormone (TSH) is elevated. If you are already taking a form of thyroxine, it is possible that that your dose is too low or that you have forgotten to take it on occasion. It may be that an increase in dose is in order - if adjusted it would be sensible to repeat thyroid function (TFT) testing in around 2 months’ time. If you are not taking thyroxine, and this is the first time TSH has been noted to be high, it is possible that 'non-thyroidal illness' or other medication effects are the cause of the elevation. It may be that hypothyroidism (underactive thyroid gland) is about to develop. In these scenarios, it would be advisable to repeat thyroid function tests in 3 months’ time. I would suggest undertaking this repeat test sooner if symptoms develop. The positive thyroid antibody result, however, increases the possibility of your having or ultimately developing autoimmune thyroid disease, such as Hashimoto's thyroiditis or Grave's disease.
A high CRP (C reactive protein) is associated with inflammation (as seen for example with arthritis or infection) from some cause. It is not an exact test, and is nonspecific. Although the rise in your case is marginal, an elevated CRP is not a normal finding and its presence should lead to further investigation to establish the cause. If you are unwell with symptoms suggesting infection or inflammation, please see your usual doctor soon. If you have no symptoms, it would be sensible to repeat this test in around 4-6 weeks’ time as it may just be a temporary rise, and if persistently elevated it would be sensible to discuss this finding with your doctor.
The folate (folic acid) level is low. Folate is one of the B group of vitamins found in green vegetables in particular. The body's reserves of folate, unlike vitamin B12, are low and only sufficient for about four months. Causes of deficiency include reduced intake from the diet or from poor absorption through the gut; increased demand for folate (eg pregnancy) and side effects of some medication (eg methotrexate). Symptoms include fatigue, mild sensation changes and depression. Prolonged lack of folate results in megaloblastic anaemia (in which the red blood cells are characteristically large). Supplementation would be advisable - I advise you to discuss this result with your usual doctor.
There is Vitamin D insufficiency. Vitamin D is manufactured in our skin as a direct result of sunlight exposure. One potential complication of prolonged Vitamin D lack is osteomalacia, a disease which causes severe structural deformities to the skeleton. Lower level Vitamin D deficiency can lead to a number of non-specific symptoms, including possibly chronic fatigue (experts have for many years noted an association between sufferers of chronic fatigue syndrome or myalgic encephalitis (CFS or ME) and low blood levels of Vitamin D). It has been estimated that between 50-70% of people living in the northern Europe (where daylight length reduces your chances of receiving adequate sunlight in the winter) are deficient in this vitamin by March each year. Symptoms of vitamin D deficiency include chronic pain, weak bones, frequent infections (recent research has detected an association between vitamin D deficiency and severe pneumonia), depression and fatigue. Supplementation may be beneficial, I suggest you discuss this finding with your usual doctor.
The Vitamin B12 level is borderline insufficient. Although within laboratory guidelines, some experts believe levels of 400-500 are desirable and that levels below this may lead to symptoms. Low Vitamin B12 levels can lead to Pernicious Anaemia (PA), a state of deficiency of the red blood cells in which there is reduced quality and number. Characteristically, the red blood cells are enlarged in this state (if the deficiency is severe and longstanding). Vitamin B12 is commonly found in many foods, particularly meats. Deficiency can develop if intake of the vitamin is reduced or if absorption from the gut is impaired. Poor absorption owing to a deficiency of Intrinsic Factor (IF) is the underlying reason for PA. Vitamin B12 deficiency in the longer run can lead to nervous system disorders - with sensation changes, loss of power or co-ordination, gut disorders and (rarely) dementia or mental illness. Lower level deficiency has been associated with a range of symptoms such as fatigue, memory impairment, irritability, depression and personality changes.
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