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a new platform for ADC development….no sorry, it’s DAC this time! not PCa related but hopefully soon
”Orum has granted Vertex rights to conduct research using its TPD² approach to developing degrader-antibody conjugates (DACs), next-generation versions of antibody-drug conjugates (ADCs) which use antibodies to precisely deliver small molecule targeted protein degrader payloads to cancer cells and other
”Orum has granted Vertex rights to conduct research using its TPD² approach to developing degrader-antibody conjugates (DACs), next-generation versions of antibody-drug conjugates (ADCs) which use antibodies to precisely deliver small molecule targeted protein degrader payloads to cancer cells and other
Maxone73
in
Advanced Prostate Cancer
3 months ago
Advice
I did a post a few weeks ago ,regarding commencing anticoagulants on a regular basis,previously had a PIP arrangement.Well my GP got clearance from a Cardiologist at the local hospital ,so I was good to go.I already had a supply of Apixaban ,previously prescribed by another GP,so I didn't need another
I did a post a few weeks ago ,regarding commencing anticoagulants on a regular basis,previously had a PIP arrangement.Well my GP got clearance from a Cardiologist at the local hospital ,so I was good to go.I already had a supply of Apixaban ,previously prescribed by another GP,so I didn't need another
highbury44
in
Atrial Fibrillation Support
3 months ago
preventing clots what are the chances?
Someone recently posted that cardios found a clot before a procedure, even though they were on anticoagulants ... someone else posted that anticoagulants are only 75% safe in preventing clots due to AF ... which was a bit of a surprise I found studies comparing Edoxaban with Warfarin where it seems
Someone recently posted that cardios found a clot before a procedure, even though they were on anticoagulants ... someone else posted that anticoagulants are only 75% safe in preventing clots due to AF ... which was a bit of a surprise I found studies comparing Edoxaban with Warfarin where it seems
108cat
in
Atrial Fibrillation Support
3 months ago
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CBD Gummy Bears
Has anyone used the CBD Gummy Bears 10mg for sleep, mild pain relief etc. I am trying to find out any interactions with medication. They seem to be ok with Flecainide but cannot find anything to do with Apixaban. Found a slight caution with warfarin but not anything to do with the newer anticoagulants
Has anyone used the CBD Gummy Bears 10mg for sleep, mild pain relief etc. I am trying to find out any interactions with medication. They seem to be ok with Flecainide but cannot find anything to do with Apixaban. Found a slight caution with warfarin but not anything to do with the newer anticoagulants
Frances123
in
Atrial Fibrillation Support
3 months ago
Recently diagnosed
I was diagnosed about a month ago. I was hospitalized with bilateral PEs. I have been on eliquis since but my pulmonologist is putting me on warfarin which I read is what I should have been on. At my follow up with him yesterday, he said I was triple positive. I know I still need another round of testing
I was diagnosed about a month ago. I was hospitalized with bilateral PEs. I have been on eliquis since but my pulmonologist is putting me on warfarin which I read is what I should have been on. At my follow up with him yesterday, he said I was triple positive. I know I still need another round of testing
Vmarti
in
Hughes Syndrome APS Forum
3 months ago
Taking extra Hydrea on weekends
Hi all, Hope everybody is keeping as well as possible and you can enjoy the summer days, even with the strange weather this year :) Personally, I have been enjoying the cooler temperatures as I can get out 😊 I have ET and PV and have been on Hydrea for 7 months now (interferon didn't work). Initially
Hi all, Hope everybody is keeping as well as possible and you can enjoy the summer days, even with the strange weather this year :) Personally, I have been enjoying the cooler temperatures as I can get out 😊 I have ET and PV and have been on Hydrea for 7 months now (interferon didn't work). Initially
JustKeepSw1mming
in
MPN Voice
3 months ago
PV , Rux, and Cardiovascular issues
Hi, I am undergoing tests on my heart and have been diagnosed with pulmonary hypertension. The tests are not yet complete so I shall continue on 20 mg Rux and aspirin until they are. My haemotologist thinks it has not been caused by the Rux but maybe PV.I would like to hear from anybody else who has
Hi, I am undergoing tests on my heart and have been diagnosed with pulmonary hypertension. The tests are not yet complete so I shall continue on 20 mg Rux and aspirin until they are. My haemotologist thinks it has not been caused by the Rux but maybe PV.I would like to hear from anybody else who has
JP1952
in
MPN Voice
3 months ago
clopidogrel
hello, I’m on clopidogrel and aspirin third week post my op (I have aneurysm secured by stent)and as I was warned I’m bruising a lot but also have severe pain inside my arms ,at times. It might sound a bit weird, but it’s like my bones rotted inside. Is anyone heard something similar?
hello, I’m on clopidogrel and aspirin third week post my op (I have aneurysm secured by stent)and as I was warned I’m bruising a lot but also have severe pain inside my arms ,at times. It might sound a bit weird, but it’s like my bones rotted inside. Is anyone heard something similar?
Hidden
in
MPN Voice
3 months ago
APS and leaky gut
Hello all, I am writing regarding my daughter who has APS. She has been taking rather large doses of Coumadin for about 20 years now. She eats a very healthy mostly vegetation and mostly organic diet. She has recently had a blood test that revealed a severe sensitivity to very many types of food.
Hello all, I am writing regarding my daughter who has APS. She has been taking rather large doses of Coumadin for about 20 years now. She eats a very healthy mostly vegetation and mostly organic diet. She has recently had a blood test that revealed a severe sensitivity to very many types of food.
monticello
in
Hughes Syndrome APS Forum
3 months ago
Foot ulcer
hi, i have a ulcer on my left foot, i had it for the last 20 months, i had a vascular app, it wasn’t vascular and recently i had a dermatology app at hospital, they said is a venous ulcer due to fact that i’m staying too much on my leg. I changed recently the painkillers prescription due to having too
hi, i have a ulcer on my left foot, i had it for the last 20 months, i had a vascular app, it wasn’t vascular and recently i had a dermatology app at hospital, they said is a venous ulcer due to fact that i’m staying too much on my leg. I changed recently the painkillers prescription due to having too
pufuletz
in
Pain Concern
3 months ago
Stopping Rivaroxaban
The community cardiac team has changed me from rivaroxaban to edoxaban as the abdominal pain was so bad. I can't get new prescription until later in the week but I stopped the rivaroxaban already, didn't take it yesterday. How long does it take for pain to settle after discontinuing ? Just wondered
The community cardiac team has changed me from rivaroxaban to edoxaban as the abdominal pain was so bad. I can't get new prescription until later in the week but I stopped the rivaroxaban already, didn't take it yesterday. How long does it take for pain to settle after discontinuing ? Just wondered
Exhiker
in
Atrial Fibrillation Support
3 months ago
foot swelling
Hi All On 10mg Pred all ok except that the soles of my feet feel swollen now I am also taking Amlodipine and Clopidogrel so got an appointment with GP on Friday (28th) and am wondering the following I have been on Amlodipine for about 10yrs been on pred for about 5 months been on Clopi for about 4weeks
Hi All On 10mg Pred all ok except that the soles of my feet feel swollen now I am also taking Amlodipine and Clopidogrel so got an appointment with GP on Friday (28th) and am wondering the following I have been on Amlodipine for about 10yrs been on pred for about 5 months been on Clopi for about 4weeks
Northernarcher
in
PMRGCAuk
3 months ago
GCA (2018)to FMD(2024) Yikes!
Hello good people. I was diagnosed in Feb, 2018 with GCA and am happy to report that I'm in remission. Last month I had arterial scans done and they came back-much to my delight- with no signs on active inflammation or aneurisms. There was, however, what they term an incidental finding by the name FMD
Hello good people. I was diagnosed in Feb, 2018 with GCA and am happy to report that I'm in remission. Last month I had arterial scans done and they came back-much to my delight- with no signs on active inflammation or aneurisms. There was, however, what they term an incidental finding by the name FMD
Blurry62
in
PMRGCAuk
3 months ago
Rituximab Infusions
My Rheumatologist advised to stop the adalimumab injections because of my hair loss and has recommended a six monthly Rituximab infusion. Has anyone experienced this treatment - for better, or, worse?
My Rheumatologist advised to stop the adalimumab injections because of my hair loss and has recommended a six monthly Rituximab infusion. Has anyone experienced this treatment - for better, or, worse?
Nannalyn
in
NRAS
3 months ago
Meds vs Ablation
Hello all, I’m weighing the decision of meds vs ablation for my Afib. I am currently doing fine on meds, Xarelto and 50mg Flecainide 2x daily that my cardiologist prescribed. However, I am waiting on a referral to an electrophysiologist. While waiting, I am trying to learn and gather as much info
Hello all, I’m weighing the decision of meds vs ablation for my Afib. I am currently doing fine on meds, Xarelto and 50mg Flecainide 2x daily that my cardiologist prescribed. However, I am waiting on a referral to an electrophysiologist. While waiting, I am trying to learn and gather as much info
Metalmani
in
Atrial Fibrillation Support
4 months ago
High platelets due to ET or MF is anyone on anticoagulants such as Clexane or Heparin?
If you are on anticoagulants what platelet numbers do you have? Are any of you also on hydroxycarbamide too?
If you are on anticoagulants what platelet numbers do you have? Are any of you also on hydroxycarbamide too?
jointpain
in
MPN Voice
4 months ago
Sore knee and pain gels
I know on Apixaban I can’t take an anti inflammatory or even the gels. I’ve got a painful knee. I asked in Boots about this stuff. Pharmacist said he couldn’t say. Anyone here heard of it, used it, know it’s ok with Apixaban? 😀
I know on Apixaban I can’t take an anti inflammatory or even the gels. I’ve got a painful knee. I asked in Boots about this stuff. Pharmacist said he couldn’t say. Anyone here heard of it, used it, know it’s ok with Apixaban? 😀
LordGabriel
in
Atrial Fibrillation Support
4 months ago
Amlodipine
Hi everyone, Just been prescribed Amlodipine for high blood pressure to join one or two other drugs post Open Heart op 3 years a go. Trying to find out if it worsens RLS which I have suffered badly for years......since "quality sleep" is advised for high BP (which of course I never get) I do not want
Hi everyone, Just been prescribed Amlodipine for high blood pressure to join one or two other drugs post Open Heart op 3 years a go. Trying to find out if it worsens RLS which I have suffered badly for years......since "quality sleep" is advised for high BP (which of course I never get) I do not want
funnyfennel
in
Restless Legs Syndrome
4 months ago
Why is my RO changing from Degerelix to Lupron after a month?
my husband started ADT treatment and RO informed him that after a month he will switch to Lupron. Is there a reason why he is doing this? As Lupron I read causes depression, anxiety. And if hopefully Degerelix works why change it? Can we request he not ? TIA.
my husband started ADT treatment and RO informed him that after a month he will switch to Lupron. Is there a reason why he is doing this? As Lupron I read causes depression, anxiety. And if hopefully Degerelix works why change it? Can we request he not ? TIA.
SherryKahn
in
Advanced Prostate Cancer
4 months ago
Red Cell Distribution Width
Hi…my blood tests have been showing ‘normal’ fr Crp Esr …everything except a consistently high Red cell distribution width above 18 I have been diagnosed with GCA but could this mean more likely Vasculitis am worried
Hi…my blood tests have been showing ‘normal’ fr Crp Esr …everything except a consistently high Red cell distribution width above 18 I have been diagnosed with GCA but could this mean more likely Vasculitis am worried
Havanahula
in
PMRGCAuk
4 months ago
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