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ANAVEX®2-73 (Blarcamesine) AVATAR Phase 3 Trial met Primary and Secondary Efficacy Endpoints - Rett syndrome
Primary and all secondary efficacy and safety endpoints met for the treatment of adult patients with Rett syndrome, with consistent improvements in RSBQ AUC (p = 0.037), ADAMS (p = 0.010) and CGI-I (p = 0.037) response Efficacy endpoints demonstrated statistically significant and clinically meaningful
Primary and all secondary efficacy and safety endpoints met for the treatment of adult patients with Rett syndrome, with consistent improvements in RSBQ AUC (p = 0.037), ADAMS (p = 0.010) and CGI-I (p = 0.037) response Efficacy endpoints demonstrated statistically significant and clinically meaningful
Hidden
in
Cure Parkinson's
2 years ago
Doctors who know Hughes and its comorbidity
Hi Especially to Kelly in West Texas I am in NJ with APS and all those usual add ons like Lupus but -I also have Hemophilia B and Porphyria. I had Dr.Erkan confirm the APS And had to have 3 surgeries last year at HSS for a fracture. I recently read you traveled to London to meet Dr. Hughes and also
Hi Especially to Kelly in West Texas I am in NJ with APS and all those usual add ons like Lupus but -I also have Hemophilia B and Porphyria. I had Dr.Erkan confirm the APS And had to have 3 surgeries last year at HSS for a fracture. I recently read you traveled to London to meet Dr. Hughes and also
BeachHaven123
in
Hughes Syndrome APS Forum
2 years ago
Pulmonary vein isolation
Hello. Has anyone here gone through radio frequency ablation for pulmonary veins isolation? I know they have to pierce the atrial wall to get to the veins and I am curious if it's painful? I have gone through two ablations which were much simpler, never left the right atrium and I was mildly sedated
Hello. Has anyone here gone through radio frequency ablation for pulmonary veins isolation? I know they have to pierce the atrial wall to get to the veins and I am curious if it's painful? I have gone through two ablations which were much simpler, never left the right atrium and I was mildly sedated
Sakhay
in
AF Association
2 years ago
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CONSTIPATION
Does anyone use MILK OF MAGNESIA daily for constipation to keep the transit going in the bowel A consultant recommended it at hospital. also has anyone tried MIRALAX.
Does anyone use MILK OF MAGNESIA daily for constipation to keep the transit going in the bowel A consultant recommended it at hospital. also has anyone tried MIRALAX.
Maggue66
in
IBS Network
2 years ago
Living with congenital Hypothyroidism
My name is Amanda this is my experience. I was born with Hypothyroidism, it has been with me all my life. I recently discovered that cow's milk suppresses levothyroxine/synthroid if you are from USA, from working correctly so I changed to lacto free or oat milk. I am now on 150mg of levothyroxine.
My name is Amanda this is my experience. I was born with Hypothyroidism, it has been with me all my life. I recently discovered that cow's milk suppresses levothyroxine/synthroid if you are from USA, from working correctly so I changed to lacto free or oat milk. I am now on 150mg of levothyroxine.
Betterme2022
in
Thyroid UK
2 years ago
Start Besremi Tomorrow
Tomorrow is the day I start Besremi. I was dx with PV 4/15 (tax day in US) in 2016. Since then I've only had phlebotomies and taken aspirin. I've had no major issues or challenges other than low ferritin which I believe contributed to some fatigue. Immediately upon dx, I began educating myself on treatment
Tomorrow is the day I start Besremi. I was dx with PV 4/15 (tax day in US) in 2016. Since then I've only had phlebotomies and taken aspirin. I've had no major issues or challenges other than low ferritin which I believe contributed to some fatigue. Immediately upon dx, I began educating myself on treatment
Elizka
in
MPN Voice
2 years ago
Vocal Cord Paralysis
Hello All, I had my first surgery in 2013 and my surgeon “nicked” my left vocal cord. It has been paralysed since. My voice was barely above a whisper for over a year and gradually got better. It’s still not the best but it’s better. For the last few years (probably at least 5) I have been back and
Hello All, I had my first surgery in 2013 and my surgeon “nicked” my left vocal cord. It has been paralysed since. My voice was barely above a whisper for over a year and gradually got better. It’s still not the best but it’s better. For the last few years (probably at least 5) I have been back and
Kaylee1211
in
Thyroid UK
2 years ago
an unwelcome running partner! 🧁
Week 6 run 2. Should be uneventful, right? Wrong. It was dark this evening. Damp, cold without a frost, and no friendly moon to light a silvery path. I set off keenly along the row of houses, each fiercely blazing with outdoor security lights. The damp chill in the air dispelled any lingering warmth
Week 6 run 2. Should be uneventful, right? Wrong. It was dark this evening. Damp, cold without a frost, and no friendly moon to light a silvery path. I set off keenly along the row of houses, each fiercely blazing with outdoor security lights. The damp chill in the air dispelled any lingering warmth
dreamrun
Graduate
in
Couch to 5K
2 years ago
Pain post-hysterectomy
Hello, I'm 13 weeks post-hysterectomy and endo excision, which I opted for as all else failed. I had endo and adenomyosis- long story! I seemed to be doing really well, and now today I was awake very early due to pain and crazy bloating. I can barely sit up or walk, it's horrible. I did try some stretches
Hello, I'm 13 weeks post-hysterectomy and endo excision, which I opted for as all else failed. I had endo and adenomyosis- long story! I seemed to be doing really well, and now today I was awake very early due to pain and crazy bloating. I can barely sit up or walk, it's horrible. I did try some stretches
Smiles-are-free
in
Endometriosis UK
2 years ago
Electroconvulsive Therapy Intervention for Parkinson’s Disease
Have not heard of this option before: Electroconvulsive Therapy Intervention for Parkinson’s Disease https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4655896/ CONCLUSION Our review of the literature supports the use of ECT as an effective treatment for alleviating refractory motor symptoms in people
Have not heard of this option before: Electroconvulsive Therapy Intervention for Parkinson’s Disease https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4655896/ CONCLUSION Our review of the literature supports the use of ECT as an effective treatment for alleviating refractory motor symptoms in people
Bolt_Upright
in
Cure Parkinson's
2 years ago
Oxazepam withdrawal and Tapering
The doctors are trying to taper me off benzodiazepine tablets and it is hell . I have been taking a low dose for twenty years and they have been very helpful in my debilitating anxiety, now they want me to take antidepressants instead . Starting withdrawal at the same time as starting a new drug is
The doctors are trying to taper me off benzodiazepine tablets and it is hell . I have been taking a low dose for twenty years and they have been very helpful in my debilitating anxiety, now they want me to take antidepressants instead . Starting withdrawal at the same time as starting a new drug is
Loughborough53
in
Anxiety Support
2 years ago
Undescended Testis
newbies! Hi. Am 31 of age with 1 undescended testicle at the left side of my groin. Early last yr I met a urologist for solution but the word he used "we'll make a try" so am afraid if it won't get worst after trial. I feels mild pain and it rise as unusual sometimes. Though I feel ok during intercus
newbies! Hi. Am 31 of age with 1 undescended testicle at the left side of my groin. Early last yr I met a urologist for solution but the word he used "we'll make a try" so am afraid if it won't get worst after trial. I feels mild pain and it rise as unusual sometimes. Though I feel ok during intercus
ET_dreams
in
Men's Health Forum
2 years ago
25 weeks pregnant. how to prepare for normal delivery?
Hi, how are you? Today i went to my gynecologist who will do my delivery. I am 25 weeks pregnant. Every thing is okay just baby is in breached position. We generally ask what should we expect i will do normal delivery or csection. He said be prepared for c section. But honestly i want normal delivery
Hi, how are you? Today i went to my gynecologist who will do my delivery. I am 25 weeks pregnant. Every thing is okay just baby is in breached position. We generally ask what should we expect i will do normal delivery or csection. He said be prepared for c section. But honestly i want normal delivery
Hiramunir78
in
Fertility Network UK
2 years ago
Is Rectal and Vaginal pain normal for endo?
I have endo and I've recently been put on the pill as a tri-cycle. This is my first period since and I'm now taking the pill again after the break. Recently I've been experiencing what I can only describe as a dull ache and twinge in my rectum and in my vagina. At the least it's uncomfortable and at
I have endo and I've recently been put on the pill as a tri-cycle. This is my first period since and I'm now taking the pill again after the break. Recently I've been experiencing what I can only describe as a dull ache and twinge in my rectum and in my vagina. At the least it's uncomfortable and at
EternalSunshine87
in
Endometriosis UK
2 years ago
School Residential Trip
My son is 9 and has always suffered from an overactive bladder. He has to really rush to the toilet when he needs to go. At school he's allowed to leave class without asking whenever he needs to and he wears padded under pants which help if he doesn't quite make it in time, but they won't contain a
My son is 9 and has always suffered from an overactive bladder. He has to really rush to the toilet when he needs to go. At school he's allowed to leave class without asking whenever he needs to and he wears padded under pants which help if he doesn't quite make it in time, but they won't contain a
Quink
in
ERIC
2 years ago
Loose bowels
Hello Lovely people Does anyone else suffer from having to run to the toilet after you’ve eaten something? Mine is getting beyond a joke now I ve even started to take loperamide to stop it . It comes on sometimes without reason . I eat a healthy diet …no meat dairy or gluten Could it be my meds ? Rituximab
Hello Lovely people Does anyone else suffer from having to run to the toilet after you’ve eaten something? Mine is getting beyond a joke now I ve even started to take loperamide to stop it . It comes on sometimes without reason . I eat a healthy diet …no meat dairy or gluten Could it be my meds ? Rituximab
Fifi2
in
NRAS
2 years ago
Pneumonia Recovery Issue
I just recovered from viral pneumonia after being diagnosed on 11-11-2022. Is it common, after all this time to have good and bad days (meaning feeling well then the next day feeling like a truck hit me) and also my breathing hasn't quite returned to normal either. It's not real bad, but it is noticeable
I just recovered from viral pneumonia after being diagnosed on 11-11-2022. Is it common, after all this time to have good and bad days (meaning feeling well then the next day feeling like a truck hit me) and also my breathing hasn't quite returned to normal either. It's not real bad, but it is noticeable
slram
in
Lung Conditions Community Forum
2 years ago
Paediatric appointment coming up
Hi My 4 year old son has his first paediatric appointment coming up and I’m wondering what I should ask. He has been on movicol over a year, in the summer we disimpacted then did maintenance dose but continued to get wee and poo accidents including at school. Recently we actually reduced his dose and
Hi My 4 year old son has his first paediatric appointment coming up and I’m wondering what I should ask. He has been on movicol over a year, in the summer we disimpacted then did maintenance dose but continued to get wee and poo accidents including at school. Recently we actually reduced his dose and
Hannah1589
in
ERIC
2 years ago
Desmopressin stopped working
Hi there, this is my first time posting, and I'm hoping others in similar situations can share advice. My 11 year old son still wets the bed. He's been using desmopressin and an alarm since October. Initially things got better (waking up sooner when the alarm sounded, and fewer wet nights) to the point
Hi there, this is my first time posting, and I'm hoping others in similar situations can share advice. My 11 year old son still wets the bed. He's been using desmopressin and an alarm since October. Initially things got better (waking up sooner when the alarm sounded, and fewer wet nights) to the point
CherryRose13
in
ERIC
2 years ago
Slow colon transit time - fiber diet - soluble or insoluble - inputs please
Morning hope you are all well - as you may gather from my previous post I have IBS-C with despepsia , however during a recent consultation the Gastro guy it was suggested I should review my fiber intake as he thinks I may have slow transit of the colon. This could well be the case given the way my constipation
Morning hope you are all well - as you may gather from my previous post I have IBS-C with despepsia , however during a recent consultation the Gastro guy it was suggested I should review my fiber intake as he thinks I may have slow transit of the colon. This could well be the case given the way my constipation
guitarman49
in
IBS Network
2 years ago
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