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Expectations
I have undergone 45 radiation treatments and am on my last month of Eligard. PSA is undetectable and my T is barely existent. No mets detected on prior pet scans. My Urologist and Oncologist are giving me congrats. I understand this is probably a temporary remission (g 4+3 - stage 2/3) but I wonder
I have undergone 45 radiation treatments and am on my last month of Eligard. PSA is undetectable and my T is barely existent. No mets detected on prior pet scans. My Urologist and Oncologist are giving me congrats. I understand this is probably a temporary remission (g 4+3 - stage 2/3) but I wonder
Eadgbe
in
Advanced Prostate Cancer
3 months ago
Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
5 months ago
PSA vs Testosterone at high T levels - Linear Model
This is a plot of PSA versus Testosterone in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?v=wafNZV-Hkqk The green point is from Safraidi (2022): https://oamjms.eu/index.php/mjms/article/view/9388 Note the
This is a plot of PSA versus Testosterone in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?v=wafNZV-Hkqk The green point is from Safraidi (2022): https://oamjms.eu/index.php/mjms/article/view/9388 Note the
janebob99
in
Advanced Prostate Cancer
5 months ago
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Rising ALP and declining PSA
Hello. I am on Xtandi as last ditch effort after Zytiga and Pluvicto eventually failed. After starting I have declining PSA but dramatically rising ALP. Any thoughts on what this means? Thanks all.
Hello. I am on Xtandi as last ditch effort after Zytiga and Pluvicto eventually failed. After starting I have declining PSA but dramatically rising ALP. Any thoughts on what this means? Thanks all.
jersy
in
Advanced Prostate Cancer
3 months ago
PSMA Scan to be scheduled - thank you Tall Allen
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
Geno2853
in
Advanced Prostate Cancer
5 months ago
ADT IS DONE. NEXT?
Lupron and Zytiga will have completed 2 years of each in June. I've read some continue Lupron for 3 years or longer. How do you know how long to take? Monitor testosterone and PSA how often? 2 or 3 months?
Lupron and Zytiga will have completed 2 years of each in June. I've read some continue Lupron for 3 years or longer. How do you know how long to take? Monitor testosterone and PSA how often? 2 or 3 months?
rfgh20
in
Advanced Prostate Cancer
3 months ago
Had Davinci RP w/ LNR 8 Reoccurrence in Bed, PSA Rising 0.77 CANNOT Do Radiation active Crohn Disease / Colitis, What about Cryotherapy?
Please Help Me Out, What Can I Do? After resolving incontinence after RP w/ PLNR (8) on 03/14/2033 Had Davinci Radical Prostatectomy with Lymph Node Removal on 03/14/2023 Only 8 Lymph Nodes Removed, according to operating urologist surgeon that is what he saw to remove I brought onto my team
Please Help Me Out, What Can I Do? After resolving incontinence after RP w/ PLNR (8) on 03/14/2033 Had Davinci Radical Prostatectomy with Lymph Node Removal on 03/14/2023 Only 8 Lymph Nodes Removed, according to operating urologist surgeon that is what he saw to remove I brought onto my team
Shorehousejam
in
Advanced Prostate Cancer
3 months ago
Anyone on Nubeqa mono therapy with prostate in place?
wondering if there is anyone on this protocol while still having their prostate in place. What are the side effects and PSA profile? Thank you.
wondering if there is anyone on this protocol while still having their prostate in place. What are the side effects and PSA profile? Thank you.
Steel67
in
Advanced Prostate Cancer
3 months ago
Help to do BAT treatment for my dad. Located in Norway.
Hello everyone! Writing on behalf of my father who is 67 yo and has prostate cancer. We are based in Norway. Prostatectomy done in March -17. Treated with Bicalutamide and Zoladex injection until rise in PSA 18 months ago. Increasing PSA from 6-12 on chemotherapy through last summer. September he was
Hello everyone! Writing on behalf of my father who is 67 yo and has prostate cancer. We are based in Norway. Prostatectomy done in March -17. Treated with Bicalutamide and Zoladex injection until rise in PSA 18 months ago. Increasing PSA from 6-12 on chemotherapy through last summer. September he was
VonKantarellen
in
Advanced Prostate Cancer
5 months ago
Does this mark the beginning of castration resistance?
Hi all, I have been quietly reading all of your posts and comments in the background since my dad's diagnosis with Stage IV adenocarcinoma (Gleason 9 (4+5)) with distal bone metastases in September 2022. My dad's PSA at diagnosis was 150. He is 64. Since May 2023, dad has been on monthly Degarelix
Hi all, I have been quietly reading all of your posts and comments in the background since my dad's diagnosis with Stage IV adenocarcinoma (Gleason 9 (4+5)) with distal bone metastases in September 2022. My dad's PSA at diagnosis was 150. He is 64. Since May 2023, dad has been on monthly Degarelix
Agh-2022
in
Advanced Prostate Cancer
3 months ago
Diet for ADT
(Duplicate post from Advanced Prostate Cancer). What diet should I be following while on ADT for the next two years? Guidelines from handout sheets are contradictary and unclear. I have been on Orgovyx for almost three months, starting on February 27, 2024. My PSA has dropped from 9.2 to 1.2 to 0.9
(Duplicate post from Advanced Prostate Cancer). What diet should I be following while on ADT for the next two years? Guidelines from handout sheets are contradictary and unclear. I have been on Orgovyx for almost three months, starting on February 27, 2024. My PSA has dropped from 9.2 to 1.2 to 0.9
Worked_the_World
in
Prostate Cancer Network
3 months ago
Diet for duration of ADT?
What diet should I be following while on ADT for the next two years? Guidelines from handout sheets are contradictary and unclear. I have been on Orgovyx for almost three months, starting on February 27, 2024. My PSA has dropped from 9.2 to 1.2 to 0.9. My Gleason Score is 9 in six cores and 6 in one
What diet should I be following while on ADT for the next two years? Guidelines from handout sheets are contradictary and unclear. I have been on Orgovyx for almost three months, starting on February 27, 2024. My PSA has dropped from 9.2 to 1.2 to 0.9. My Gleason Score is 9 in six cores and 6 in one
Worked_the_World
in
Advanced Prostate Cancer
3 months ago
Statin use and mortality risk in men on ADT.
New ADT study from Hong Kong (1). "A total of 4920 patients were included, consisting of 2578 statin users and 2342 non-users (mean age 76.1 ± 8.2 years). Over a mean follow-up period of 4.2 ± 3.3 years, it was observed that statin users had significantly lower risks of both PCa-related mortality
New ADT study from Hong Kong (1). "A total of 4920 patients were included, consisting of 2578 statin users and 2342 non-users (mean age 76.1 ± 8.2 years). Over a mean follow-up period of 4.2 ± 3.3 years, it was observed that statin users had significantly lower risks of both PCa-related mortality
pca2004
in
Fight Prostate Cancer
7 months ago
PSA doubled in last 30 days after 4 months stable since Provenge. What's next?
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
SViking
in
Advanced Prostate Cancer
5 months ago
Hysteroscopy - general anaesthetic?
hi I’m going to be having a Hysteroscopy in a few months. Have just come out of hospital after being admitted for 4 days due to a horrendous infection in one of my fallopian tubes. Whilst in hospital they discovered reoccurrence of cysts on both ovaries , I have a huge fibroid which is 10cm it used
hi I’m going to be having a Hysteroscopy in a few months. Have just come out of hospital after being admitted for 4 days due to a horrendous infection in one of my fallopian tubes. Whilst in hospital they discovered reoccurrence of cysts on both ovaries , I have a huge fibroid which is 10cm it used
Menopausal7
in
Menopause and Perimenopause Support
10 months ago
Clinical Trial PT 112 ?
I’m writing for my husband who is French (I’m English : we live in France ) He’s 65 and was diagnosed in March 2022 - already metastatic : PSA 36 (previous test 18months before was normal ) Mets in spine and pelvis also liver . Enantone 3 monthly injections and Zytiga to start with. PSA went down
I’m writing for my husband who is French (I’m English : we live in France ) He’s 65 and was diagnosed in March 2022 - already metastatic : PSA 36 (previous test 18months before was normal ) Mets in spine and pelvis also liver . Enantone 3 monthly injections and Zytiga to start with. PSA went down
Enilorac63
in
Advanced Prostate Cancer
5 months ago
Is it PSA recurrence or not...
My friend had a radical prostatectomy a year ago. Since then his monthly PSA results were stable, at 0.006 3 months ago his PSA went from 0.006 to 0.012, then the next month to 0.029. His MO wanted to see the third month's results in order to consider salvage radiation therapy. Luckily, third month's
My friend had a radical prostatectomy a year ago. Since then his monthly PSA results were stable, at 0.006 3 months ago his PSA went from 0.006 to 0.012, then the next month to 0.029. His MO wanted to see the third month's results in order to consider salvage radiation therapy. Luckily, third month's
traveller64
in
Advanced Prostate Cancer
5 months ago
Mortality Probability after first PSA rise vs non-castrate testosterone levels (low vs Normal)
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
janebob99
in
Advanced Prostate Cancer
5 months ago
First PSA after RARP
My dad had RARP on Jan 19,2024. Gleason 8(4+4) PSA 12, clean PSMA pet scan before surgery. Path report had no LN SVI or EPE but PNI and 50 percent prostate involvement. PSA today 6 weeks post surgery came out to .09. What should we do next? Age 73. Tall_Allen Please advice. Thanks a lot for your help
My dad had RARP on Jan 19,2024. Gleason 8(4+4) PSA 12, clean PSMA pet scan before surgery. Path report had no LN SVI or EPE but PNI and 50 percent prostate involvement. PSA today 6 weeks post surgery came out to .09. What should we do next? Age 73. Tall_Allen Please advice. Thanks a lot for your help
Pca2024
in
Advanced Prostate Cancer
5 months ago
PSA reduction after Estrogen Patch Therapy
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
janebob99
in
Advanced Prostate Cancer
5 months ago
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