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Barry
Hi, Diagnosed with advanced prostate cancer stage 4 gleeson score 4+4, having six monthly degarelix injections, had bad side effects on second injection upset stomach diorea feeling very drained, wondering if 3 monthly injections would be better less chemical in system?
Hi, Diagnosed with advanced prostate cancer stage 4 gleeson score 4+4, having six monthly degarelix injections, had bad side effects on second injection upset stomach diorea feeling very drained, wondering if 3 monthly injections would be better less chemical in system?
littlemount
in
Advanced Prostate Cancer
6 months ago
PSA Bounce After Radiation Therapy
I am trying to understand PSA bounce or change in PSA levels after RT and have found two studies useful. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465291/ https://www.nature.com/articles/s41391-021-00387-4 Some analysts distinguish between PSA bounce and biological recurrence, and see a possibility
I am trying to understand PSA bounce or change in PSA levels after RT and have found two studies useful. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465291/ https://www.nature.com/articles/s41391-021-00387-4 Some analysts distinguish between PSA bounce and biological recurrence, and see a possibility
kainasar
in
Advanced Prostate Cancer
4 months ago
My experience with Docetaxel
I know everyone doesn’t respond the same but here is my experience and what I went through with 10 rounds of chemo. Before I started I had already been on Lupron for five years, I had radiation to multiple bone Mets, took zytiga/xtandi, had Provenge and did a clinical trial. October 26 2023 I started
I know everyone doesn’t respond the same but here is my experience and what I went through with 10 rounds of chemo. Before I started I had already been on Lupron for five years, I had radiation to multiple bone Mets, took zytiga/xtandi, had Provenge and did a clinical trial. October 26 2023 I started
Oct18
in
Advanced Prostate Cancer
3 months ago
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What comes after, what comes next?
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
lgutman
in
Advanced Prostate Cancer
3 months ago
Phase 1 trial shows promising results for fractionated dose of 225Ac-J591 in PCa treatment
The fractionated dosing achieved promising results with 95% of patients experiencing any PSA decline and 71% achieving a PSA50 response. In contrast, the multiple cycles cohort saw 72% of patients with any PSA decline and 28% achieving a PSA50 response...fractionate good! https://www.urotoday.com/conference-highlights
The fractionated dosing achieved promising results with 95% of patients experiencing any PSA decline and 71% achieving a PSA50 response. In contrast, the multiple cycles cohort saw 72% of patients with any PSA decline and 28% achieving a PSA50 response...fractionate good! https://www.urotoday.com/conference-highlights
Maxone73
in
Advanced Prostate Cancer
3 months ago
177Lu-PSMA-617: Trial shows it's more effective than changing ARPIs
"Patients who enrolled in the trial were assigned to either a change in ARPI, for example from abiraterone to enzalutamide or vice versa, or 177Lu-PSMA-617, a prostate-specific antigen (PSMA)-targeted radioligand therapy. This analysis found that treatment with 177Lu-PSMA-617 prolonged radiographic progression-free
"Patients who enrolled in the trial were assigned to either a change in ARPI, for example from abiraterone to enzalutamide or vice versa, or 177Lu-PSMA-617, a prostate-specific antigen (PSMA)-targeted radioligand therapy. This analysis found that treatment with 177Lu-PSMA-617 prolonged radiographic progression-free
Maxone73
in
Advanced Prostate Cancer
3 months ago
Am I becoming castrate resistant on orgovix?
I moved again and hopefully this will be the last time. So, I have had to put together a new Medical team and meet my new MO this Tuesday. My bio is pretty up to date. I'm stage 4 and have some lymph node mets and some bone mets. It's been over a year since my last scan which showed improvement from
I moved again and hopefully this will be the last time. So, I have had to put together a new Medical team and meet my new MO this Tuesday. My bio is pretty up to date. I'm stage 4 and have some lymph node mets and some bone mets. It's been over a year since my last scan which showed improvement from
Startech
in
Advanced Prostate Cancer
4 months ago
radiation treatment delayed
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
thansen535
in
Advanced Prostate Cancer
3 months ago
radiation treatment delayed
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
thansen535
in
Advanced Prostate Cancer
3 months ago
Advice - Surgery or Radiation?
Hi all, apologies for the long post, hoping to give as much info as possible. Background: Diagnosis: Unfavorable int-risk prostate cancer (T2a, Gleason 4+3, PSA 5.2) (I spoke to a surgeon today who said it was T3a so now I am confused) Age: 59 PSA 5.2 (H) 01/31/2024 PSA 4.4 (H) 11/06/2023 PSA
Hi all, apologies for the long post, hoping to give as much info as possible. Background: Diagnosis: Unfavorable int-risk prostate cancer (T2a, Gleason 4+3, PSA 5.2) (I spoke to a surgeon today who said it was T3a so now I am confused) Age: 59 PSA 5.2 (H) 01/31/2024 PSA 4.4 (H) 11/06/2023 PSA
Blue1320
in
Prostate Cancer Network
3 months ago
Prostate cancer treatment and sexual mutilation
Well well. In the midst of the club no one wants to be a part of and just wanted to add my input. It seems that the treatment of prostate cancer often glazes over the fact that you will be sexually impacted severely. Depending on treatment outcome that could be a 0 to 7. Seems like the topic isn’t really
Well well. In the midst of the club no one wants to be a part of and just wanted to add my input. It seems that the treatment of prostate cancer often glazes over the fact that you will be sexually impacted severely. Depending on treatment outcome that could be a 0 to 7. Seems like the topic isn’t really
Yokohama2023
in
Advanced Prostate Cancer
6 months ago
UPDATE
UPDATE Hi folks, I havnt been very active recently - mostly because things were going slowly, but well with my PCA. Ive just had my latest bloodwork which confirms a PCA increase with a doubling time of about 6 months. This is all very standard and to be expected - I am 4.3 years out from PSA of 1000
UPDATE Hi folks, I havnt been very active recently - mostly because things were going slowly, but well with my PCA. Ive just had my latest bloodwork which confirms a PCA increase with a doubling time of about 6 months. This is all very standard and to be expected - I am 4.3 years out from PSA of 1000
Stoneartist
in
Advanced Prostate Cancer
4 months ago
Xofigo anyone?
So my PSA is rising after Chemo, Lupron and NUBEQA (Darolutamide). It rose from 0.04 in June 2023 to 0.84 at the end on April 2024 with latest time of doubling about 5 weeks, 2.3 years after diagnosis. I don't have organ on lymph node metastasis yet. My oncologists team suggests Xofigo/Ra-223 as a next
So my PSA is rising after Chemo, Lupron and NUBEQA (Darolutamide). It rose from 0.04 in June 2023 to 0.84 at the end on April 2024 with latest time of doubling about 5 weeks, 2.3 years after diagnosis. I don't have organ on lymph node metastasis yet. My oncologists team suggests Xofigo/Ra-223 as a next
Oldie68
in
Advanced Prostate Cancer
3 months ago
News about phase 1 trial for mCRPC: BMS-986365
Plenty of hopefully good news at ASCO 2024 on the 25th of Jan "First disclosure of clinical outcomes from Phase 1 trial with BMS-986365 (CC-94676), the company’s first androgen receptor ligand-directed degrader in solid tumors from its targeted protein degradation platform, in metastatic castration-resistant
Plenty of hopefully good news at ASCO 2024 on the 25th of Jan "First disclosure of clinical outcomes from Phase 1 trial with BMS-986365 (CC-94676), the company’s first androgen receptor ligand-directed degrader in solid tumors from its targeted protein degradation platform, in metastatic castration-resistant
Maxone73
in
Advanced Prostate Cancer
6 months ago
Almost 3 years on ADT + Erleada
I am almost 3 years on ADT I was diagnosed as stage 4 with a bone biopsy on a lesion.My MO started me with monthly firmagon injections and zytiga in 2021 july then switched to lupron and Erleada after a few months since I had a reaction to Abi after a couple of months .Erleada also gave me rash in
I am almost 3 years on ADT I was diagnosed as stage 4 with a bone biopsy on a lesion.My MO started me with monthly firmagon injections and zytiga in 2021 july then switched to lupron and Erleada after a few months since I had a reaction to Abi after a couple of months .Erleada also gave me rash in
mynacho
in
Advanced Prostate Cancer
3 months ago
Brachyboost and PSA progression free survival question
We just received our appointment summary from the radiation oncologist and there is a comment in it that is confusing me. It’s not how I remember the conversation, so I am wondering if someone can clarify ( Tall_Allen ?). ”We can proceed with EBRT followed by LDR brachytherapy boost and minimum 6 months
We just received our appointment summary from the radiation oncologist and there is a comment in it that is confusing me. It’s not how I remember the conversation, so I am wondering if someone can clarify ( Tall_Allen ?). ”We can proceed with EBRT followed by LDR brachytherapy boost and minimum 6 months
EvFC
in
Advanced Prostate Cancer
3 months ago
Pet Scan Below, Does Non Avid PSMA Liver Lesions mean possible Neuroendocrine Cancer
EXAM: PET-CT SKULL BASE TO MID-THIGH CLINICAL HISTORY: Metastatic prostate cancer, rising PSA TECHNIQUE: PET/CT skull base to thigh-subsequent treatment strategy F18 PYL dose: 10.00 millicuries Injection site: L AC Time of injection: 17:00 Time of emission scan: 18:06 Oral Contrast
EXAM: PET-CT SKULL BASE TO MID-THIGH CLINICAL HISTORY: Metastatic prostate cancer, rising PSA TECHNIQUE: PET/CT skull base to thigh-subsequent treatment strategy F18 PYL dose: 10.00 millicuries Injection site: L AC Time of injection: 17:00 Time of emission scan: 18:06 Oral Contrast
Shorehousejam
in
Advanced Prostate Cancer
3 months ago
PSA test
my husband had a PSA done and it raised from 0,5 to 0,7. He finished proton radiation las year January, the PSA went down to 0,5. is this normal, or should he take any action? He will be 81 years old this coming September, would it be okay to let it go. Has anybody have this experience? Thank you for
my husband had a PSA done and it raised from 0,5 to 0,7. He finished proton radiation las year January, the PSA went down to 0,5. is this normal, or should he take any action? He will be 81 years old this coming September, would it be okay to let it go. Has anybody have this experience? Thank you for
Grommi
in
Advanced Prostate Cancer
3 months ago
Should go into the OMAHA2a ODM-208 (MK-5684-004): phase 3 trial?
I had my 3 monthly OC visit last week. Blood test is showing 0.3 up from 0.15 six weeks ago. MO is suggesting that I should go into the ODM-208 (MK-5684): phase 3 trial if PSA rises above 1.0. PSA of 1.0 or above is a entry requirement for the trial, presumable to be sure that my current treatment
I had my 3 monthly OC visit last week. Blood test is showing 0.3 up from 0.15 six weeks ago. MO is suggesting that I should go into the ODM-208 (MK-5684): phase 3 trial if PSA rises above 1.0. PSA of 1.0 or above is a entry requirement for the trial, presumable to be sure that my current treatment
LakeT
in
Advanced Prostate Cancer
3 months ago
Had Pet Scan, PSA rising 0.77 Found Liver Metastases, Am I a dead man? What can I do?
Going for MRI and Biopsy What can I do?
Going for MRI and Biopsy What can I do?
Shorehousejam
in
Advanced Prostate Cancer
3 months ago
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