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CAR T-Cell Therapy Demonstrates Promising Results for mCRPC
A total of 14 patients were treated between August 2019 and July 2022. The median patient age was 62 in dose level 1 (DL1), 70 for dose level 2 (DL2), and 69 for dose level 3 (DL3). The baseline prostate-specific antigen (PSA) ranged from 16.5 ng/mL to 235.3 ng/mL. Primary end points were safety and
A total of 14 patients were treated between August 2019 and July 2022. The median patient age was 62 in dose level 1 (DL1), 70 for dose level 2 (DL2), and 69 for dose level 3 (DL3). The baseline prostate-specific antigen (PSA) ranged from 16.5 ng/mL to 235.3 ng/mL. Primary end points were safety and
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
Xeloda neck pain
On first week xeloda and I get severe neck and face pain once a day..I take a klonpin and tylenol and relieved in half hour..I don't know if anyone else has it.ROX
On first week xeloda and I get severe neck and face pain once a day..I take a klonpin and tylenol and relieved in half hour..I don't know if anyone else has it.ROX
Mcangel11
in
SHARE Metastatic Breast Cancer
3 months ago
My own PSA values over time: 70% drop in just 3 months on Dutasteride and no ADT
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
janebob99
in
Prostate Cancer Network
7 months ago
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surgery
well it’s been a while since I posted my fellow warriors Started having hip issues a couple of months ago. Did a Ct and MRI as well as X-rays. Found that the ball was gone off my left hip , then on closer inspection found that the right hip the cancer had eaten all the way thru the upper femur ?
well it’s been a while since I posted my fellow warriors Started having hip issues a couple of months ago. Did a Ct and MRI as well as X-rays. Found that the ball was gone off my left hip , then on closer inspection found that the right hip the cancer had eaten all the way thru the upper femur ?
larry_dammit
in
Advanced Prostate Cancer
3 months ago
Doubling Times and PSA acceleration - Part II
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
janebob99
in
Prostate Cancer Network
7 months ago
Wondering what to do
Hello I have not posted for a while but I wondered if any had any thoughts to help me with my dilemma. I have had 18 rounds of chemo and rucaparib all of which have been successful for a while. I also had surgery in 2020 when I was diagnosed. My last lot of single carbo chemo have me a stable few months
Hello I have not posted for a while but I wondered if any had any thoughts to help me with my dilemma. I have had 18 rounds of chemo and rucaparib all of which have been successful for a while. I also had surgery in 2020 when I was diagnosed. My last lot of single carbo chemo have me a stable few months
BadgerBright
in
My Ovacome
3 months ago
PSA levels will increase over time, depending on the level of testosterone - Part I
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
janebob99
in
Prostate Cancer Network
7 months ago
Shirley
I MBC that had spread to bones now found two small spots on lungs. I was taking ansezole for estrogen blocker and venezico .I am ER statuses positive , HER2 negative. They say I have mutation on my cancer an wants me take a treatment PIQKAY and Fulvestrant. I am very nervous taking these. ANYONE
I MBC that had spread to bones now found two small spots on lungs. I was taking ansezole for estrogen blocker and venezico .I am ER statuses positive , HER2 negative. They say I have mutation on my cancer an wants me take a treatment PIQKAY and Fulvestrant. I am very nervous taking these. ANYONE
Moonfry
in
SHARE Metastatic Breast Cancer
3 months ago
Baseline PSMA-Pet scan?
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
duxlubber
in
Advanced Prostate Cancer
7 months ago
Are you in London? Next Information Day 13/3
Hello all, If you have had a diagnosis or are supporting someone with lung cancer you might be interested in joining our next Information Day. This will be held from 9.45 - 15.30 in London at the AFC Wimbledon club SW17 0NR. The day will have updates on targeted therapies, surgery and other treatments
Hello all, If you have had a diagnosis or are supporting someone with lung cancer you might be interested in joining our next Information Day. This will be held from 9.45 - 15.30 in London at the AFC Wimbledon club SW17 0NR. The day will have updates on targeted therapies, surgery and other treatments
LorraineD
Roy Castle
in
The Roy Castle Lung Cancer Foundation
7 months ago
Help! Anyone here try zytiga holidays. Like one week off a month. Or weekends off?
Help! Anyone here try zytiga holidays for 2-7 days every so often? Also, any recommended medications recommended to stop these hot flashes. I only take the 250mg because I get the same affect. With 1000 mg I have heart problems.Thanks4673
Help! Anyone here try zytiga holidays for 2-7 days every so often? Also, any recommended medications recommended to stop these hot flashes. I only take the 250mg because I get the same affect. With 1000 mg I have heart problems.Thanks4673
Gdheals
in
Advanced Prostate Cancer
7 months ago
Bowel preparation before surgery
Hi everyone! 💛 Just been on pre op assessment and nurse said I don’t need to do bowel preparation at home. I will have hysterectomy with bowel resection and Endo excision. Has anyone had bowel preparation at hospital just before the operation? I am quite concerned what is going on 🤷♀️
Hi everyone! 💛 Just been on pre op assessment and nurse said I don’t need to do bowel preparation at home. I will have hysterectomy with bowel resection and Endo excision. Has anyone had bowel preparation at hospital just before the operation? I am quite concerned what is going on 🤷♀️
Endolemon
in
Endometriosis UK
7 months ago
Newly diagnosed with HCC
I am a 78 year old retired educator who has battled GIST CANCER for 20 years. To my surprise, An HCC tumor was found in my liver in between two GIST tumors. in my June 5 MRI. The GIST tumors were shrinking out of site thanks to be taking Gleevec, a targeted therapy drug. My surgeon could not safely resect
I am a 78 year old retired educator who has battled GIST CANCER for 20 years. To my surprise, An HCC tumor was found in my liver in between two GIST tumors. in my June 5 MRI. The GIST tumors were shrinking out of site thanks to be taking Gleevec, a targeted therapy drug. My surgeon could not safely resect
Dachshund45
in
Blue Faery Liver Cancer
3 months ago
A Secondary Primary Malignancy hit me
The doctors tell us that you don't die from CLL; you die with CLL. What they don't tell you very often is that even though it isn't the CLL that gets you, it could very well be a secondary primary malignancy caused by the CLL that does it. Bennevisplace wrote on this a few months ago; i.e. the fact
The doctors tell us that you don't die from CLL; you die with CLL. What they don't tell you very often is that even though it isn't the CLL that gets you, it could very well be a secondary primary malignancy caused by the CLL that does it. Bennevisplace wrote on this a few months ago; i.e. the fact
hhk50
in
CLL Support
3 months ago
Tomorrow is finally the day of my MRI after waiting 3 1/2 months since the ultrasound and CT scan couldn't be sure of a mass or not.
After having to postpone my original MRI appt last month due to the death of my mother, I am finally getting it done tomorrow. Those who haven't read my previous posts, a fibroid and possible ovarian mass were found on an incidental CT scan back in March where I was diagnosed with diverticulitis after
After having to postpone my original MRI appt last month due to the death of my mother, I am finally getting it done tomorrow. Those who haven't read my previous posts, a fibroid and possible ovarian mass were found on an incidental CT scan back in March where I was diagnosed with diverticulitis after
starrynight5626
in
My Ovacome
3 months ago
AI and prostate cancer, early days, but interesting
https://www.medindia.net/news/ai-reveals-subtypes-in-prostate-cancer-enhancing-treatment-215102-1.htm Apparently AI has helped analyze PCa from micro and macro evolutionary perspective and identified two sub types. "Our research demonstrates that prostate tumors evolve along multiple pathways, leading
https://www.medindia.net/news/ai-reveals-subtypes-in-prostate-cancer-enhancing-treatment-215102-1.htm Apparently AI has helped analyze PCa from micro and macro evolutionary perspective and identified two sub types. "Our research demonstrates that prostate tumors evolve along multiple pathways, leading
FRTHBST
in
Prostate Cancer Network
7 months ago
Non metastasis castrate resistant
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
Sailameme
in
Advanced Prostate Cancer
7 months ago
MY pBAT Stats From June to March 8 months
Hi All, Just thought I would give an update on my pBAT (Testosterone propianate BAT) for the last 8 months. I do T propianate injections every other day while on High T for 2 weeks then slam the door with Darolutamide for 2 weeks and then one week to clear the Daro. Rinse and repeat. I also take intermittent
Hi All, Just thought I would give an update on my pBAT (Testosterone propianate BAT) for the last 8 months. I do T propianate injections every other day while on High T for 2 weeks then slam the door with Darolutamide for 2 weeks and then one week to clear the Daro. Rinse and repeat. I also take intermittent
KocoPr
in
Fight Prostate Cancer
7 months ago
Guided bacteria, 100% effective in preclinical trials
well, I am citing... "With a 100% remission rate and no meaningful side effects in all the subjects of the company's preclinical trials, this technology is conceived to address all solid tumors, representing 90% of cancer and 89% of deaths." Even 50% of that result in humans would be amazing! https
well, I am citing... "With a 100% remission rate and no meaningful side effects in all the subjects of the company's preclinical trials, this technology is conceived to address all solid tumors, representing 90% of cancer and 89% of deaths." Even 50% of that result in humans would be amazing! https
Maxone73
in
Advanced Prostate Cancer
3 months ago
Very promising: PIP Polyspecific Integrin-Binding Peptide, a novel and very flexible platform
Basically, they have developed a technology that can simultaneously bind to different "proteins" expressed by cancers. This means a wider specificity. One cancer mutation could express for example KRAS 12C and another KRAS 12D (just an example using terms and mutation I know!) and the chemo drug would
Basically, they have developed a technology that can simultaneously bind to different "proteins" expressed by cancers. This means a wider specificity. One cancer mutation could express for example KRAS 12C and another KRAS 12D (just an example using terms and mutation I know!) and the chemo drug would
Maxone73
in
Advanced Prostate Cancer
3 months ago
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