Very promising: PIP Polyspecific Integrin-Binding Peptide, a novel and very flexible platform

[Maxone73]

Basically, they have developed a technology that can simultaneously bind to different "proteins" expressed by cancers. This means a wider specificity. One cancer mutation could express for example KRAS 12C and another KRAS 12D (just an example using terms and mutation I know!) and the chemo drug would bind to both variants.

biospace.com/article/releas...

[6357axbz]

I haven’t read the article but I have a question. Most of us here are old men. Does “very promising” mean in our lifetime?

[Maxone73 in reply to 6357axbz]

Speed is increasing now that in silico techniques are used extensively but I doubt before 5-7 years unless you are enrolled in a clinical trial. But there are many other interesting molecules that are already in phase 2 or 3, which means on the market in few years.

[GreenStreet in reply to Maxone73]

Yes we need to try and stick around long enough for something to turn up!

[lokibear0803 in reply to Maxone73]

First thing - your continued posts around these emerging technologies are mucho appreciated. Thank you!

Second thing - if-when you get a chance, could you extract a list of those molecules/technologies/etc that you believe have a window of “a few years” for us?

As if you’re not doing a ton-load for us already. This could be a heavy lift, so only if you’re willing, Max.

Many thanks regardless.

[Maxone73 in reply to lokibear0803]

I have a google doc called “hopes and dreams” where I have started to write down and check trials when I was diagnosed. I have kept it updated, also because it brought me good luck (I chose ARASENS and I got it without having to fight with my MO) and from time to time I check all the trials in my list to see their current status. Maybe I could try to do what you have asked on my next update?

[lokibear0803 in reply to Maxone73]

Anything at all that you’re willing to do would be awesome. Pls feel no urgency on this - I could probably resurrect my own spreadsheet on this same idea (it’s by now ancient), but I’m lazy 😎 and I think you’re more diligent 🧐

If it’s simpler, perhaps just a list of the promising treatments w/o worrying too much about related trials.

FWIW, some time ago, my approach was to construct URLs that execute on-demand searches for each particular therapy, and look at the ct.gov results every now and then. So this gave me an updated list of all trials for a given drug/etc. I should probably get back to doing that…

[j-o-h-n]

Pip Pip Hooray!

Good Luck, Good Health and Good Humor.

j-o-h-n

[Maxone73]

”While TwoStep is the company targeting tumor-associated integrins using PIP, other companies are interested in the potential of targeting tumor-associated integrins. Novartis for example, has a Phase I clinical trial testing a radioligand therapy for patients with advanced or metastatic tumors that express two integrins. Pfizer also has a drug for solid tumors in testing that also targets an integrin—one of the same ones that PIP targets.”

Update!

[Maxone73]

If I got it right one of their researchers won a Nobel in 2022

journals.aai.org/jimmunol/a...

cell.com/cell-chemical-biol...