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177Lu-PSMA-617: Trial shows it's more effective than changing ARPIs
"Patients who enrolled in the trial were assigned to either a change in ARPI, for example from abiraterone to enzalutamide or vice versa, or 177Lu-PSMA-617, a prostate-specific antigen (PSMA)-targeted radioligand therapy. This analysis found that treatment with 177Lu-PSMA-617 prolonged radiographic progression-free
"Patients who enrolled in the trial were assigned to either a change in ARPI, for example from abiraterone to enzalutamide or vice versa, or 177Lu-PSMA-617, a prostate-specific antigen (PSMA)-targeted radioligand therapy. This analysis found that treatment with 177Lu-PSMA-617 prolonged radiographic progression-free
Maxone73
in
Advanced Prostate Cancer
5 months ago
mastectomy now tamoxifen
I’m 48 and just had a double mastectomy almost 4 weeks ago. My bc tumor was 1.2 cm and ER/PR positive and HER 2 negative with an onco type score of 21 and nymph nodes were negative. I was hoping I was done with treatment, but was told I need to take tamoxifen. I read a lot of horrible stories about
I’m 48 and just had a double mastectomy almost 4 weeks ago. My bc tumor was 1.2 cm and ER/PR positive and HER 2 negative with an onco type score of 21 and nymph nodes were negative. I was hoping I was done with treatment, but was told I need to take tamoxifen. I read a lot of horrible stories about
Lulu427
in
SHARE Breast Cancer Support
5 months ago
Is this decision right for me
I had a PSMA pet scan on 7/16/2024. The result shows a single tumor in my left lung measuring 8mm. My MO wants me to have the tumor radiated and monitor the PSA and its doubling time. A little background, I'm just short of 83 years old. I had prostatectomy in 2009, PSA undetectable until 2017. I had
I had a PSMA pet scan on 7/16/2024. The result shows a single tumor in my left lung measuring 8mm. My MO wants me to have the tumor radiated and monitor the PSA and its doubling time. A little background, I'm just short of 83 years old. I had prostatectomy in 2009, PSA undetectable until 2017. I had
old64horn
in
Advanced Prostate Cancer
2 months ago
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radiation treatment delayed
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
thansen535
in
Advanced Prostate Cancer
5 months ago
radiation treatment delayed
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
thansen535
in
Advanced Prostate Cancer
5 months ago
Advice - Surgery or Radiation?
Hi all, apologies for the long post, hoping to give as much info as possible. Background: Diagnosis: Unfavorable int-risk prostate cancer (T2a, Gleason 4+3, PSA 5.2) (I spoke to a surgeon today who said it was T3a so now I am confused) Age: 59 PSA 5.2 (H) 01/31/2024 PSA 4.4 (H) 11/06/2023 PSA
Hi all, apologies for the long post, hoping to give as much info as possible. Background: Diagnosis: Unfavorable int-risk prostate cancer (T2a, Gleason 4+3, PSA 5.2) (I spoke to a surgeon today who said it was T3a so now I am confused) Age: 59 PSA 5.2 (H) 01/31/2024 PSA 4.4 (H) 11/06/2023 PSA
Blue1320
in
Prostate Cancer Network
5 months ago
Blood
Well after tests on low red cells turned out to be a polyp which was removed and a large tumour in the bowel which was positive I am 3 weeks into recovery from bowel resection just waiting for preventative chemotherapy all is good first post in a while due to surgery etc
Well after tests on low red cells turned out to be a polyp which was removed and a large tumour in the bowel which was positive I am 3 weeks into recovery from bowel resection just waiting for preventative chemotherapy all is good first post in a while due to surgery etc
ChillyAsh34
in
MPN Voice
5 months ago
Clinical trial news
Has anyone been 'volunteered ' for this new trial from Astra Zanaca? Saruparib (AZD5305) vs Placebo in Men with Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents - EvoPAR-PR01 This is looking at whether adding a new drug on top of taking an Androgen Receptor
Has anyone been 'volunteered ' for this new trial from Astra Zanaca? Saruparib (AZD5305) vs Placebo in Men with Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents - EvoPAR-PR01 This is looking at whether adding a new drug on top of taking an Androgen Receptor
Max24
in
Advanced Prostate Cancer
5 months ago
Hay fever medicines
I continue to have badly blocked ears and a runny nose for several weeks. I’ve only managed to see paramedics rather than a GP about it. I haven’t used any nasal sprays (other than saline) but would like to try anti-allergy medication such as antihistamine. Yet I’ve read that “A few common stimulating
I continue to have badly blocked ears and a runny nose for several weeks. I’ve only managed to see paramedics rather than a GP about it. I haven’t used any nasal sprays (other than saline) but would like to try anti-allergy medication such as antihistamine. Yet I’ve read that “A few common stimulating
Samazeuilh2
in
Atrial Fibrillation Support
5 months ago
CRISPR news: protein arginine methyltransferase 7 as a novel essential gene in prostate cancer metastasis (in vitro)
Now, tell me how to deal with it! https://pubmed.ncbi.nlm.nih.gov/38432581/
Now, tell me how to deal with it! https://pubmed.ncbi.nlm.nih.gov/38432581/
Maxone73
in
Advanced Prostate Cancer
5 months ago
CAR-T: new phase 1 trial will soon start to enroll
P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC) Promising preclinical tests, but it's a phase 1 trial https://clinicaltrials.gov/study/NCT04249947
P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC) Promising preclinical tests, but it's a phase 1 trial https://clinicaltrials.gov/study/NCT04249947
Maxone73
in
Advanced Prostate Cancer
5 months ago
Surgery or radiation, looking for some advices
Hi everyone, I’m looking for some advices for my father. He was recently diagnosed with prostate cancer. He probably already had it for a long time. Quite high PSA (way over 20), and spread to multiple lymph nodes. The surgeon said surgery is still doable, followed by radiation. Radiation oncologist
Hi everyone, I’m looking for some advices for my father. He was recently diagnosed with prostate cancer. He probably already had it for a long time. Quite high PSA (way over 20), and spread to multiple lymph nodes. The surgeon said surgery is still doable, followed by radiation. Radiation oncologist
Healing1826
in
Advanced Prostate Cancer
5 months ago
Free Download - Prostate Cancer Comic Book about stage IV
Our wonderful community member James Burns has created a full-length comic book about his experiences with stage IV prostate cancer. Get your free download here: https://malecare.org/prostate-cancer-comic-book
Our wonderful community member James Burns has created a full-length comic book about his experiences with stage IV prostate cancer. Get your free download here: https://malecare.org/prostate-cancer-comic-book
Darryl
Partner
in
Advanced Prostate Cancer
5 months ago
Xofigo anyone?
So my PSA is rising after Chemo, Lupron and NUBEQA (Darolutamide). It rose from 0.04 in June 2023 to 0.84 at the end on April 2024 with latest time of doubling about 5 weeks, 2.3 years after diagnosis. I don't have organ on lymph node metastasis yet. My oncologists team suggests Xofigo/Ra-223 as a next
So my PSA is rising after Chemo, Lupron and NUBEQA (Darolutamide). It rose from 0.04 in June 2023 to 0.84 at the end on April 2024 with latest time of doubling about 5 weeks, 2.3 years after diagnosis. I don't have organ on lymph node metastasis yet. My oncologists team suggests Xofigo/Ra-223 as a next
Oldie68
in
Advanced Prostate Cancer
5 months ago
PSA down with Enzalutamide 160 and Wysolone 5 mg
My father has had a relapse of long controlled PSA in 2022 and his PSA levels went upto 10.58; abieraterone didn't work ; he was also put on Docetaxal, he could tolerate one dose of it only and was stopped on this...he is on Enzalutamide 160 along with Wysolone 5 mg for the last 4 months...with his
My father has had a relapse of long controlled PSA in 2022 and his PSA levels went upto 10.58; abieraterone didn't work ; he was also put on Docetaxal, he could tolerate one dose of it only and was stopped on this...he is on Enzalutamide 160 along with Wysolone 5 mg for the last 4 months...with his
Ij2023
in
Advanced Prostate Cancer
5 months ago
Prolia shots
After 4+ years of Actonel is Prolia a good choice for continued treatment of osteoporosis? I will be asking my rheumatologist the same question next time I see her. I am due for another bone scan so she will most likely want to see that first but based on the first 2 tests I am going downhill bone-wise
After 4+ years of Actonel is Prolia a good choice for continued treatment of osteoporosis? I will be asking my rheumatologist the same question next time I see her. I am due for another bone scan so she will most likely want to see that first but based on the first 2 tests I am going downhill bone-wise
Alebeau
in
PMRGCAuk
5 months ago
What next? re maintenance for HGS recurrence
Would love to know if any ladies who has also been unsuccessful with Olaparib, what has been a successful maintenance for you? I’ve just got 2 cycles more of Carbo/Caelyx, min scan showed slight reduction not as good as hoped for. Only maintenance mentioned by oncologist is to go on Letrozole. I
Would love to know if any ladies who has also been unsuccessful with Olaparib, what has been a successful maintenance for you? I’ve just got 2 cycles more of Carbo/Caelyx, min scan showed slight reduction not as good as hoped for. Only maintenance mentioned by oncologist is to go on Letrozole. I
Towergirl
in
My Ovacome
5 months ago
Almost 3 years on ADT + Erleada
I am almost 3 years on ADT I was diagnosed as stage 4 with a bone biopsy on a lesion.My MO started me with monthly firmagon injections and zytiga in 2021 july then switched to lupron and Erleada after a few months since I had a reaction to Abi after a couple of months .Erleada also gave me rash in
I am almost 3 years on ADT I was diagnosed as stage 4 with a bone biopsy on a lesion.My MO started me with monthly firmagon injections and zytiga in 2021 july then switched to lupron and Erleada after a few months since I had a reaction to Abi after a couple of months .Erleada also gave me rash in
mynacho
in
Advanced Prostate Cancer
5 months ago
Brachyboost and PSA progression free survival question
We just received our appointment summary from the radiation oncologist and there is a comment in it that is confusing me. It’s not how I remember the conversation, so I am wondering if someone can clarify ( Tall_Allen ?). ”We can proceed with EBRT followed by LDR brachytherapy boost and minimum 6 months
We just received our appointment summary from the radiation oncologist and there is a comment in it that is confusing me. It’s not how I remember the conversation, so I am wondering if someone can clarify ( Tall_Allen ?). ”We can proceed with EBRT followed by LDR brachytherapy boost and minimum 6 months
EvFC
in
Advanced Prostate Cancer
5 months ago
Pet Scan Below, Does Non Avid PSMA Liver Lesions mean possible Neuroendocrine Cancer
EXAM: PET-CT SKULL BASE TO MID-THIGH CLINICAL HISTORY: Metastatic prostate cancer, rising PSA TECHNIQUE: PET/CT skull base to thigh-subsequent treatment strategy F18 PYL dose: 10.00 millicuries Injection site: L AC Time of injection: 17:00 Time of emission scan: 18:06 Oral Contrast
EXAM: PET-CT SKULL BASE TO MID-THIGH CLINICAL HISTORY: Metastatic prostate cancer, rising PSA TECHNIQUE: PET/CT skull base to thigh-subsequent treatment strategy F18 PYL dose: 10.00 millicuries Injection site: L AC Time of injection: 17:00 Time of emission scan: 18:06 Oral Contrast
Shorehousejam
in
Advanced Prostate Cancer
5 months ago
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