PC drug with least side effects

[Stevegr]

After 2 years on ADT I must go to a stronger medicine. I am castrate resistant with one small met by the pelvis. Doc suggests Xthandi but I would appreciate any suggestions on anything easier. The SE scare the hell out of me

[Tall_Allen]

Instead of worrying about which side effects you might experience, why not try it and see?

[Stevegr in reply to Tall_Allen]

I will as I showed very little SE from ADT & Bicalutamide. Thanks

[MrG68]

Ever wondered why some people get cold sores outbreaks(aka herpes simplex) and other people who have the virus don't? No? Well let me tell you, cold sore sufferers try EVERYTHING and usually it doesn't work.It's because your body is totally different. It reacts differently from everyone else. What works for one person doesn't mean it will work the same way for another.

There's no way that you can predict the side effects of an aspirin for an N=1 until one day your head hurts enough and you take the plunge.

The way I see it, yes,side effects can be horrific at times. But you should also think about the side effects of not doing anything.

[Derf4223 in reply to MrG68]

Love it "the side effects of not doing anything."

[j-o-h-n in reply to MrG68]

Doctors finally found out the cause of a patient with herpes of the eyes.....

Johnny Lee - "Looking For Love in All the Wrong Places". Country Road TV•3.7M views · 3:00. Go to channel ...

Good Luck, Good Health and Good Humor.

j-o-h-n

[Mgtd in reply to j-o-h-n]

John that has to be an all time classic. Thanks for the smile and chuckle.

[God_Loves_Me]

Xthandi or nubeqa

[RyderLake2]

Hello,

I am not sure why the side effects of Xtandi (enzalutamide) "scare the hell out of you" when you haven't even tried the drug. Anecdotally, I took Xtandi for nearly six years before it started to fail. The side effects, for me, were minimal. Some fatigue, a little peripheral neuropathy which on reflection might have been a side effect of back surgery. Nothing serious and nothing I couldn't handle.

[Apisdorsata]

My experience is that Xtandi has the worst side effects of the testosterone blockers. Bicalutamide the least. Xtandi crosses the blood-brain barrier and it did a very unpleasnt job on my brain. I just laid around all day. Did not feel like doing anything, Slept a lot.

I just went off abiraterone + prednisone after a six month regimen. It kept my PSA undetectable. The side effects were much more bearable than any other program I've been on.

Likely the more aggressive programs such as leuprolide + abiraterone are more effective but unfortunately greater treatment efficacy seems to go hand in hand with greater side effects. At least for me. When I have to go back on treatment I hope to take only abiraterone /prednisone again. But if the PSA goes back up too soon and/or the PSMA scan shows any new lesions I'll probably ask for leuprolide + abiraterone. I will be discussing this with Dr. Sartor in June when I see him next.

[anonymoose2]

Good for you asking questions. Not a dam thing wrong in taking that approach.

Hope your searching gives you satisfaction and understanding.

[Justfor_]

Ρύθμισε την δόση του φαρμάκου στην ελάχιστη απαιτούμενη (min effective dosage)

[Jpburns in reply to Justfor_]

It’s all Greek to me. But Google translate says: “Adjust the dose of the medicine to the minimum required.”

[Justfor_ in reply to Jpburns]

Ancient Greek Hippocrates is still pertinent: "First, do no harm".

[j-o-h-n in reply to Justfor_]

Second:

"Get a naive cousin George as an investor/ partner in your Greek Diner".....Yiasou

Good Luck, Good Health and Good Humor.

j-o-h-n

[Justfor_ in reply to j-o-h-n]

Naive in the sense of medical treatments, or general mental status, John?

[j-o-h-n in reply to Justfor_]

In dealing with relatives/fellow Greeks........... Remember when two Greeks meet, you get three Generals....

p.s. Name of diner: Spyros and George's Gyro Gyro House... (Me Yia!)

Good Luck, Good Health and Good Humor.

j-o-h-n

[j-o-h-n in reply to Jpburns]

And without an accent...

Good Luck, Good Health and Good Humor.

j-o-h-n

[Jimbo47]

Hey Man. I appreciate that you have the balls to express your feelings. Almost everything about our attempts to slay this beast is scary. Don't be intimidated by the hard assed comments that some people will offer you.

[profsailor]

I did very well on apalutamide plus Lupron for two years.

[Doctorsceptic]

like one report below I had horrendous side effects from enzalutamide. The worst were on the brain. Headaches which ended with me in the unit on morphine PLUS severe hypertension (probable PRES) PLUS high blood triglycerides weight gain and cognitive blunting.

Make sure you are fully counselled on all the side effects and their frequency and what to do if you get any.

Also ask what the effect of the drug is on “all cause deaths” in a 79 yr old. My reading is bugger all.