ADT & Pluvicto

[Shams_Vjean]

Is it common to continue ADT treatments, like Lupron or Eligard, while receiving Pluvicto therapy?

[Tall_Allen]

Not just common, it is required.

[Shams_Vjean in reply to Tall_Allen]

Thanks!

[Hidden in reply to Tall_Allen]

Just curious…I was under the impression that in order to get Pluvicto you had to have had chemo and ADT (Lupron) but not that you must currently be on Lupron ?…

[Tall_Allen in reply to Hidden]

Some kind of ADT. It is only approved for mCRPC so far.

[spolyu in reply to Tall_Allen]

After looking at my husband's profile, what Adt should we request since he has already been on Aberatone, Xtandi and Erleada over a year ago.

Thank you

[Tall_Allen in reply to spolyu]

ADT is androgen deprivation therapy, such as Lupron. Firmagon, Orgovyx, or orchiectomy.

[Hidden in reply to Tall_Allen]

Ok got it!..thanks

[Parscore in reply to Tall_Allen]

Well unfortunate for me, I was going in for my 4th Pluvicto and my oncologist wanted me to do a bone and CT scan so I did. The small tumor in my liver has significantly in large as have a couple of bone Mets. He did not want me to take any other meds with Pluvicto. Bad news for me. Any suggestions. The Pluvicto was working on some areas such as the lymph-nods I also have not had Chemo.

[God_Loves_Me]

yes also use xtandi or nubeqa as well that’s call triplet therapy. best treatment option

[RyderLake2]

Hello,

Absolutely! I am on Lutetium 177 and I am still taking Zoladex (goserelin). Since diagnosis in 2013, I have been receiving my every three month injections of Zoladex for nearly eleven years. In my experience that the ARPI drugs (like Xtandi and Zytiga) seem to come and go but the Lupron type drugs live forever (sigh).

[Shorehousejam in reply to RyderLake2]

Do you have any mutations? Seems Pluvicto works for guys with no Germline or Genome mutations

[RyderLake2 in reply to Shorehousejam]

Not that I am aware of.

[Shorehousejam in reply to RyderLake2]

There we go, Lu 177 is a progression disaster for people with mutations, seems odd no studies on that yet.

[SeosamhM in reply to Shorehousejam]

Agreed. Before people pile on you for simply being "negative" about Lu177, here is a 2018 (4 years before FDA approval of Pluvicto!) source for them (sorry, just the abstract - the paper isn't free):

pubmed.ncbi.nlm.nih.gov/29762244/

You echo my overall concern that the medical community has relied too much on initial treatment studies and doesn't have coordinated data collection while the new treatments are rolled out into the wider population.

[Shorehousejam in reply to SeosamhM]

True

[Steve77755]

absolutely. I continued Lupron through 12 cycles of LU-177/pluvicto

[j-o-h-n]

FOR THOSE WHO ARE INTERESTED IN PLUVICTO.

---------------------------------------------------------------------------------------------------

HIGHLIGHTS OF PRESCRIB

ING INFORMATION

These highlights do not include all the information needed to use

PLUVICTO safely and effectively. See full prescribing information for

PLUVICTO.

PLUVICTO® (lutetium Lu 177 vipivotide tetraxetan) injection, for

intravenous use

Initial U.S. Approval: 2022

----------------------------INDICATIONS AND USAGE-------------------------

PLUVICTO is a radioligand therapeutic agent indicated for the treatment of

adult patients with prostate-specific membrane antigen (PSMA)-positive

metastatic castration-resistant prostate cancer (mCRPC) who have been

treated with androgen receptor (AR) pathway inhibition and taxane-based

chemotherapy. (1)

---------------------------------------------------------------------------------------------------

Good Luck, Good Health and Good Humor.

j-o-h-n

[Shorehousejam in reply to j-o-h-n]

Did you do pluvicto?

[j-o-h-n]

No I did not.............and thought it may be helpful for others to view some info (I see it all over H.U. ((Good and Bad)) reviews)...

Good Luck, Good Health and Good Humor.

j-o-h-n

[Shorehousejam in reply to j-o-h-n]

Any research, studies and / or trials on people with Germline or Genomic mutations that had Lu-177 Pluvicto? I would really like to read that instead of all the hyper progression stories on group pages online with guys with mutations

[j-o-h-n in reply to Shorehousejam]

I'll write a few, right after I take care of my ex-wife........

Good Luck, Good Health and Good Humor.

j-o-h-n