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Androgen deprivation therapy (ADT)
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PSA rising, rapidly
Well, it looks like my honeymoons of
ADT
are over. I was (and still am) on a tripple therapy along the lines of the ARASENS trial (Docetaxel, Lupron and NUBEQA) for about 2 years. My PSA started rising six months ago, at first slowly, but now very rapidly.
Well, it looks like my honeymoons of
ADT
are over. I was (and still am) on a tripple therapy along the lines of the ARASENS trial (Docetaxel, Lupron and NUBEQA) for about 2 years. My PSA started rising six months ago, at first slowly, but now very rapidly.
Oldie68
in
Advanced Prostate Cancer
4 months ago
EBRT - Is it the right thing and what to expect?
After DX in November 2018 with Stage IV and Gleason of 5+4 and 4+5, and 5 years of
ADT
of Lupron (then Orgovyx), prednisone 5mg, and Zytiga 250mg with low fat breakfast, my PSA stayed stable at 0.4 or 0.5. At end of 2013, PSA started rising to latest value of 0.84.
After DX in November 2018 with Stage IV and Gleason of 5+4 and 4+5, and 5 years of
ADT
of Lupron (then Orgovyx), prednisone 5mg, and Zytiga 250mg with low fat breakfast, my PSA stayed stable at 0.4 or 0.5. At end of 2013, PSA started rising to latest value of 0.84.
JazzMan42
in
Advanced Prostate Cancer
2 months ago
Agonists vs. antagonists (the latter not to be confused with a character in a novel!)
I know many of you on this site are beyond
ADT
, but for those who are still holding on in that space, I'd like to share my experience with the newer antagonists drugs, degarelix ( U.S. brand, Firmagon) and relugolix (U.S. brand, Orgovyx).
I know many of you on this site are beyond
ADT
, but for those who are still holding on in that space, I'd like to share my experience with the newer antagonists drugs, degarelix ( U.S. brand, Firmagon) and relugolix (U.S. brand, Orgovyx).
bluesnjazz
in
Advanced Prostate Cancer
4 months ago
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Bladder dysfunction
in 2014, diagnosed Gleason 9, had Prostate surgery, cancer metastasized to pelvic region, did
ADT
, followed by 72 Proton blasts ( 37 to cavity-35 to pelvic) Two years ago, stricture surgery ( 80% urethra blockage- all good), had stricture surgery 3 weeks ago ( 25% blockage), but bladder stopped operating
in 2014, diagnosed Gleason 9, had Prostate surgery, cancer metastasized to pelvic region, did
ADT
, followed by 72 Proton blasts ( 37 to cavity-35 to pelvic) Two years ago, stricture surgery ( 80% urethra blockage- all good), had stricture surgery 3 weeks ago ( 25% blockage), but bladder stopped operating
Tkwham
in
Advanced Prostate Cancer
7 months ago
HDR boost Brachytherapy + IMRT
All RO’s I’ve met with want to wait 2-3 months for the
ADT
to do its thing and shrink the primary tumor and lymph nodes before they that radiation start treatment. One RO I met with wants to treat with just IMRT. Another I met with wants to use HDR Brachy boost + IMRT.
All RO’s I’ve met with want to wait 2-3 months for the
ADT
to do its thing and shrink the primary tumor and lymph nodes before they that radiation start treatment. One RO I met with wants to treat with just IMRT. Another I met with wants to use HDR Brachy boost + IMRT.
Cenerus
in
Advanced Prostate Cancer
2 months ago
Full circle with this disease
Diagnosed 2017 PSA 105 started
ADT
, 6 rounds Docetaxel and radiation PSA drops to undetectable. Castrate resistant 2022 started Abiraterone and prednisone this failed after 3 months. Start Xgeva and Xofigo 2023. PSA back at 105 November 2023.
Diagnosed 2017 PSA 105 started
ADT
, 6 rounds Docetaxel and radiation PSA drops to undetectable. Castrate resistant 2022 started Abiraterone and prednisone this failed after 3 months. Start Xgeva and Xofigo 2023. PSA back at 105 November 2023.
Islandboy2021
in
Advanced Prostate Cancer
4 months ago
It's Back!
Did 39 treatments off radiation and have been mostly on
ADT
for the duration except during COVID I took a break of 18 months or so. Went metastatic about 3 1/2 to 4 years ago and started Xtandi.
Did 39 treatments off radiation and have been mostly on
ADT
for the duration except during COVID I took a break of 18 months or so. Went metastatic about 3 1/2 to 4 years ago and started Xtandi.
Tjc1
in
Advanced Prostate Cancer
4 months ago
I am livid, confused , worried and scared as hell that my ORGOVYX -ADT symptoms are mine for life.
what is the difference of being on
-Orgovyx for life and having the exact same symptoms off the drug but caused by the low testosterone you acquired off the drug and by taking the drug.
what is the difference of being on
-Orgovyx for life and having the exact same symptoms off the drug but caused by the low testosterone you acquired off the drug and by taking the drug.
JWS13
in
Advanced Prostate Cancer
8 months ago
Time to PSA Nadir is related to progression-free-survival
Cohort:
ADT
monotherapy (No RP or RT), all metastatic patients, median 74 y.o., GS = 8-10, N=419. A cubic spline curve fit matched the data points very well, with a high correlation coefficient, R^2 = 0.944, and a low p = 0.040.
Cohort:
ADT
monotherapy (No RP or RT), all metastatic patients, median 74 y.o., GS = 8-10, N=419. A cubic spline curve fit matched the data points very well, with a high correlation coefficient, R^2 = 0.944, and a low p = 0.040.
janebob99
in
Advanced Prostate Cancer
2 months ago
Thoughts on Denosumab in my case
On monthly
ADT
injections, radiation starting soon. ——————- T score interpretation according to the National Osteoporosis Foundation: T-score at or above -1.0 Normal T-score between -1.0 and -2.5 osteopenia T-score at or below -2.5 osteoporosis REGION: L-spine (L1-4): BMD (g/cm2): 1.139 g/cm2
On monthly
ADT
injections, radiation starting soon. ——————- T score interpretation according to the National Osteoporosis Foundation: T-score at or above -1.0 Normal T-score between -1.0 and -2.5 osteopenia T-score at or below -2.5 osteoporosis REGION: L-spine (L1-4): BMD (g/cm2): 1.139 g/cm2
Hope49823
in
Advanced Prostate Cancer
3 months ago
ADT 's effect on body fat and muscle mass from Life on ADT blog by Richard Wassersug
ADT’s impact on Muscle and Fat October 23, 2023 Standard
ADT
with either LHRH agonist or antagonist drugs (like Lupron or Firmagon, respectively) cause a loss of lean muscle mass and weight gained as fat. Those are among the most common side effects of
ADT
.
ADT’s impact on Muscle and Fat October 23, 2023 Standard
ADT
with either LHRH agonist or antagonist drugs (like Lupron or Firmagon, respectively) cause a loss of lean muscle mass and weight gained as fat. Those are among the most common side effects of
ADT
.
Scout4answers
in
Advanced Prostate Cancer
7 months ago
New Developments in My Husband's PCA Journey
If we can stall or delay progression with the hopes of my husband having a durable remission or even the potential to take a break from
ADT
, then we deemed it worth it.
If we can stall or delay progression with the hopes of my husband having a durable remission or even the potential to take a break from
ADT
, then we deemed it worth it.
103532
in
Advanced Prostate Cancer
5 months ago
Update
Tomorrow I’ll receive my next 3-month Lupron shot, which will finalize my 24-month
ADT
after prostate bed and whole pelvic radiation.
Tomorrow I’ll receive my next 3-month Lupron shot, which will finalize my 24-month
ADT
after prostate bed and whole pelvic radiation.
Nusch
in
Advanced Prostate Cancer
7 months ago
question for those who have stopped Lupron after many years of ADT
I have been on Lupron for 8 years with the short-term exception of a high/T clinical trial,( but even during the trial I stayed on Lupron). Anyway I’m undetectable and decided to stop Lupron. 3 months after not getting my shot my T is now a whopping 37. I am curious to hear from some of you who
I have been on Lupron for 8 years with the short-term exception of a high/T clinical trial,( but even during the trial I stayed on Lupron). Anyway I’m undetectable and decided to stop Lupron. 3 months after not getting my shot my T is now a whopping 37. I am curious to hear from some of you who
Chugach
in
Advanced Prostate Cancer
1 month ago
After bicalutimide and a high testosterone level is pre treatment T just guess work?
some input/advice/ thoughts as I make a decision on how far to push to the SOC for my high risk G9, given my oncologist is saying 15 months adjuvant (I am nervous of anything less than 18 months) is enough given my co morbidities, age at 73 , current low T at 0,6 (17) and PSA of 0.01 throughout the
ADT
some input/advice/ thoughts as I make a decision on how far to push to the SOC for my high risk G9, given my oncologist is saying 15 months adjuvant (I am nervous of anything less than 18 months) is enough given my co morbidities, age at 73 , current low T at 0,6 (17) and PSA of 0.01 throughout the
ADT
SimMartin
in
Prostate Cancer Network
5 months ago
How long does ADT affect mood swings and anger after stopping treatment ?
Hello, Usually ok but a few outbursts recently.. anger issues upset .. but generally easy going nice person. It’s almost been 2 months since last and final shot and had irrational incident. Anybody else experience challenges after therapy and was wonder when you reached a normal feeling. I generally
Hello, Usually ok but a few outbursts recently.. anger issues upset .. but generally easy going nice person. It’s almost been 2 months since last and final shot and had irrational incident. Anybody else experience challenges after therapy and was wonder when you reached a normal feeling. I generally
Yokohama2023
in
Prostate Cancer Network
1 month ago
xtandi plus talzenna
Has anyone else been down this treatment to add Talzenna to their
adt
treatments? I started only a few days ago. Side effects seem to be severe. Kidney pain, back pain, brain fog, fatigue. I stopped after only day three. Awaiting my MO to respond to the call for help.
Has anyone else been down this treatment to add Talzenna to their
adt
treatments? I started only a few days ago. Side effects seem to be severe. Kidney pain, back pain, brain fog, fatigue. I stopped after only day three. Awaiting my MO to respond to the call for help.
Apd66
in
Advanced Prostate Cancer
8 days ago
Thanks and hope to all
Brachytherapy prior with
ADT
for the last 7 months. Things seem to be going as smoothly as it sometimes does.
Brachytherapy prior with
ADT
for the last 7 months. Things seem to be going as smoothly as it sometimes does.
Yokohama2023
in
Advanced Prostate Cancer
5 months ago
ADT for a year?
Had intermediate grade PC no spread, had SBRT. Three months out my Psa is .03. Am on Lupron for the fourth month out of a projected 12 month stint. Do docs ever say, six or nine months is enough? Testosterone at 6 right now.
Had intermediate grade PC no spread, had SBRT. Three months out my Psa is .03. Am on Lupron for the fourth month out of a projected 12 month stint. Do docs ever say, six or nine months is enough? Testosterone at 6 right now.
Photographerhere
in
Prostate Cancer Network
8 months ago
Dizziness from Zytiga/prednisone?
my MO tried something out of the ordinary - let me have a 'vacation' from
ADT
for a short while, even though i am Castrate -resistant.
my MO tried something out of the ordinary - let me have a 'vacation' from
ADT
for a short while, even though i am Castrate -resistant.
Tonwantonga
in
Advanced Prostate Cancer
6 months ago
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