melatonin

[Nowhereman9]

hello. I would not recommend high dose melatonin for us who are on ADT and abiraterone. Impairs dexterity and cognitive ability.

[6357axbz]

I never had a problem. What do you consider high dose?

[Nowhereman9 in reply to 6357axbz]

100 mg to 140 mg /day

[Gl448 in reply to Nowhereman9]

That’s an insanely high dose.

Why were you trying so much?

[dhccpa in reply to Gl448]

It's widely recommended in alternative med forums for cancer. I'm just answering your question, not justifying it.

[Nowhereman9]

trying to kill the cancer

[Nowhereman9]

What is the benefit that you are shooting for?

[GSDF]

I take 120mg a day, no issues

[Gl448 in reply to GSDF]

What is the measurable benefit your getting?

[GSDF in reply to Gl448]

It doesn't matter bro... I didn't suggest anyone should take melatonin as I do or anything else that I do. I was just responding to OPs post.

I respect everyone's right to choose their own path...But to address your question, I've only read reports that high dose melatonin may possibly stall progression of metastasis... I'm not saying that's true. But my research on dosage and chatting with others who take much higher doses than I, satisfied me that what I'm taking likely won't affect me negatively, so I decided to try it.

I'll also add that I'm getting the deepest, most restful sleep I've ever known. Lower doses didn't give me that. And having been plagued with a severe insomnia condition my whole life, and now the ADT intensifying that condition, gives me reason alone that I'll maintain the melatonin 🙂✌️

[Gl448 in reply to GSDF]

Gotcha bruh...you answered my question.

[London441 in reply to GSDF]

Taking 120 mg of Melatonin a day, based on ‘research on dosage and chatting with others’…intriguing.

Actually I think pondering that dose each night should work well enough for me. Sweet dreams!

[dhccpa in reply to GSDF]

Great explanation.

[lcfcpolo]

Just to put some perspective on these amounts. In the UK melatonin is prescription only and usually for a limited time period. My GP after a long conversation, acknowledged that I can take it and prescribed 2mg per night. There are a shed load of possible side effects. Just putting this here so that any new members on this forum are aware to be cautious and check drug interactions and side effects at these massive doses being discussed. Good luck everyone and sleep well.

[Bodyp in reply to lcfcpolo]

Hi, I also take a small dose of 5mg but not regularly, as informed not of benefit if taken too often.

[Big_Mcc in reply to lcfcpolo]

Same here. I had to fight to get it. 2mg max and not even every day. I save mine up and take 4 or 6mg so I can at least have a few nights of decent sleep.

[lcfcpolo in reply to Big_Mcc]

Interesting. I've never saved up a few days. I might give this a go. Cheers.

[Tall_Allen]

People often misinterpret stuff they read on the internet and take supplements that may cause a great deal of harm and no benefit. Thanks for alerting patients that it may be dangerous to tinker with biochemistry.

[Nowhereman9]

The main researcher of melatonin indicated to up the dose till you had GI symptoms and there is lab evidence of its effect on pCA to cause apoptosis along with other benefits. The thing that we all must be wary of is the negative impact that the ADT and abiraterone have on our cognitive reserve because of the lack of testosterone. I am a proponent of firing as many canons at this curse as long as the liver, brain, and kidneys can handle the stress. In two years I hope to go on an ADT vacation and that my PSA stays at ZERO.

[Gl448 in reply to Nowhereman9]

Lab evidence is not a good reason to take massive doses of any OTC supplements along the lines of what the OP reported.

I only skimmed this PubMed article, but if I read it right, it does show significant increase in overall survival time for people with poor prognosis (Gleason 8-10 with metastases) for those given melatonin versus those not. But it also says much wider clinical study should be conducted.

The dosage given in the study was 3mg 30 minutes prior to bedtime.

ncbi.nlm.nih.gov/pmc/articl...

My only issue, for what it’s worth, with the idea of shooting as many cannons at the cancer as you can, is the expense relative to the benefit, and having no idea what’s actually helping you or not. Or worse harming you, like I suspect 100 mg of melatonin per day would do. I know you’re not suggesting that, and wish you nothing but the best in your fight against this fucking cancer.

[Bigmls7890 in reply to Gl448]

60 mg daily fine

[Gl448 in reply to Bigmls7890]

Glad you think it's okay. I wouldn't go so high without medical supervision. Other than subjective feelings of better sleep, there's no way of knowing what benefits you're getting, or what damage you're doing...

Most of us with serious disease will die sooner than later, and as long as something's not going to expedite your demise, I can't criticize its use, so more power and hopefully better health to those doing high doses.

[Hidden]

I do 10mg per night, to regulate the circadian rhythm of my pancreas. Not cancer.

(Per my Endocrinologist)

[Nowhereman9]

interesting as melatonin with the pineal gland

[Arel8]

Thanks- I need it basically to sleep. What do you consider high dose and where is this published.

[ARIES29]

I cut my 20mg tablet in half every other day & have good nights sleep & nap on the next day, so for me 10mg day is plenty.

[SierraSix]

I take a timed release 300 mcg

[Gl448 in reply to SierraSix]

So that's the equivalent to 0,3mg, or 1/10th the normally suggested dose..but yours is timed release. Interesting.

[SierraSix in reply to Gl448]

lifeextension.com/vitamins-...

[bakun8]

My ND suggested up to 50 mg./day. 5 mg>10 mg>20 mg = no sleep. Now @ 40 mg. I get drowsy. Side effects mention warfarin interferences, bp alterations, & bph^. I'll be watching...

[markrichardson]

Doris Loh is an advocate of Melatonin as part of an antiviral regime, she says what is stimulant or sedative is highly individualised, something to bare in mind. Dicksons chemist in Glasgow usually prescribe 30mg for anti cancer properties. Different brands potency varies and it seems that Pharmaceutical preparations are more potent then OTC even at the same advertised dosage. It can cause depression as one of the side effects.

[FlyJ]

I take 60mg of liposomal melatonin at night. Only SE is more vivid dreams. No day time drowsiness.

[dhccpa in reply to FlyJ]

I have also had some humdinger dreams, although only here and there.

[Mascouche]

From what I've read, people should not take melatonin ongoingly because after a while your body will stop producing it on its own because the pills are providing it.

What is supposedly safer is to take the L-Tryptophan amino acid instead. It is a precursor to melatonin so it helps your body produce more melatonin. So you get the better sleep but without the risk of your melatonin glands eventually shutting down.

[dhccpa]

I haven't had any issues after 2 months.

[MC130J]

AS an FYI not a suggestion- I am taking Melatonin with Ivermectin (6mg) under the care of a Functional medicine NP. I started with 10 mg then increased 10mg weekly to a max mg 60 mg. No issues, maintaining a PSA .1. Good Luck

[NecessarilySo]

I take 3 mg but not daily. I was chatting with AI on my computer and learned that melatonin tends to increase one's circadium rythm, i.e. sensitivity to sunlight or lack thereof, while vitamin D3 tends to increase absorption of sunlight and hence bodily creation of D3. I had been taking 5000 units of D3, and it might have led to insomnia, which led me to melatonin. AI seemed to be saying that they are conflicting.

From AI:

Vitamin D is an essential nutrient that plays a crucial role in the immune system, muscle health, and cell growth 1. Some studies suggest that adequate vitamin D levels could reduce the risk or severity of prostate cancer 1. However, the evidence is still inconclusive. The potential for vitamin D to disrupt cancer growth is well-documented, but the role of vitamin D supplementation in treating prostate cancer remains controversial 1.

A 2017 study found lower vitamin D levels in people with prostate cancer. The study also found that prostate cancer was more severe in people with the lowest vitamin D levels and found a correlation between low vitamin D and higher levels of inflammation in people with prostate cancer 1. This points to a potential role of vitamin D in preventing or slowing cancer growth but does not show that supplementation improves prostate cancer outcomes.

A 2013 study suggests that vitamin D3 supplementation may benefit patients with early stage, low-risk prostate cancer on active surveillance 1. However, people who require treatment should not use vitamin D as a replacement for standard treatments for prostate cancer 1.

In conclusion, while some studies suggest that adequate vitamin D levels could reduce the risk or severity of prostate cancer, the evidence is still inconclusive. Vitamin D should not replace standard treatments for prostate cancer 1.

____________________________________________________________________________________

Melatonin is a hormone that regulates sleep and wakefulness 1. Some studies suggest that melatonin may have an inhibitory effect on prostate cancer 2. A 2021 study found that melatonin has an inhibitory effect on human prostate cancer 2. Another study from 2014 found that men with higher levels of melatonin in their urine had a 75% decreased risk of advanced prostate cancer compared to men with lower melatonin levels 3. However, the evidence is still inconclusive, and more research is needed to determine the effectiveness of melatonin in treating prostate cancer 214.

In conclusion, while some studies suggest that melatonin may have an inhibitory effect on prostate cancer, the evidence is still inconclusive. Melatonin should not replace standard treatments for prostate cancer 214.

[j-o-h-n]

Now let me think if I can write something funny about Melatonin -big yawn-------excuse me zzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzz

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 10/12/2023 4:27 PM DST

[MateoBeach]

. . . unless you want extra help in controlling the progression of your prostate cancer:

(Note: I take 20mg at bedtime)

ncbi.nlm.nih.gov/pmc/articl...

ABSTRACT: Melatonin is an endogenous indoleamine that has been shown to inhibit tumor growth in laboratory models of prostate cancer. Prostate cancer risk has additionally been associated with exogenous factors that interfere with normal pineal secretory activity, including aging, poor sleep, and artificial light at night. Therefore, we aim to expand on the important epidemiological evidence, and to review how melatonin can impede prostate cancer. More specifically, we describe the currently known mechanisms of melatonin-mediated oncostasis in prostate cancer, including those that relate to the indolamine’s ability to modulate metabolic activity, cell cycle progression and proliferation, androgen signaling, angiogenesis, metastasis, immunity and oxidative cell status, apoptosis, genomic stability, neuroendocrine differentiation, and the circadian rhythm. The outlined evidence underscores the need for clinical trials to determine the efficacy of supplemental, adjunct, and adjuvant melatonin therapy for the prevention and treatment of prostate cancer.

[slpdvmmd]

Do you have a reference for this problem???