Experiences with

Androgen deprivation therapy (ADT)

Hi everyone, I think my ADT holiday I s getting short.I had SBRT on spot found in the iliac bone and than 18 months of ADT( no Zytiga yet).stopped ADT and only almost 4 months my PSA is rising ( 0.038) from <0.006 on May.The problem is that the Testosterone is less than 50. Castration resistance?

My take here is: patients receiving darolutamide and ADT had a 46% reduction in the risk of disease progression or death compared to those on ADT alone (hazard ratio [HR] 0.54).

Has anyone been recommended / experienced some kind of ADT break with bone mets? Thank you.

I have been on ADT vacation for 10 months now.(stage 4 with starting PSA 2250 in 2019). 2019 started on ADT and PSA has been undetectable 4 months after I started and is still. Testosterone less than 40(undetectable) and still is.

The first scan was performed in Sept 2020, after a year of ADT and zytiga, the second in September 2022, after basically a year off of ADT ( my bcr forced me to restart ADT in July 2022).

I have been reading about Testosterone recovery after ADT, and trying to get some information about the likelihood of never recovering my T at age 77 after 2 years of ADT. Is there anybody out there in their mid 70's who have completed their ADT and recovered their T?

For mHSPC, ADT + docetaxel + darolutamide demonstrates less cardiotoxicity than ADT + decetaxel + abiraterone acetate + prednisone due to a lower risk of hypertension and arrhythmias from decreased mineralocorticoid excess.

My pre-ADT testosterone was 620. Now, after four months of ADT (and radiation), it's 9. My ADT prison sentence ends September 31 (Orgovyxx). A couple guys at my gym have offered to hook me up starting in November to get my T back up quickly.

I would prefer SBRT but without ADT as I had polio at 1 years old. My muscle mass is very weak in my left leg, do worried 4-6 mo of ADT would cause too much damage. Heard outcomes are good for SBRT without ADT. Any advice? Wife is pushing surgery, but I am not sure. Thanks

I read here some do enzalutamide alone without ADT or bicalutamide alone and have low psa numbers even with their testasterone being very high Whereas for those on ADT and ARSi both they say the testosterone numbers should be low and lower the better. Can someone throw some light on this 😊

I'm on Orgovyx and Nubeqa, and we all know these ADT drugs reduce muscle mass and lead to muscle loss. Besides frequent resistance training, has anyone supplemented with creatine powder? Any benefit or side effects or counter-reactions?

Both Stanford and UCSF want to do 2 sessions of HDRB without ADT (They feel with my pathology and low decipher ADT would not provide much benefit) Uses CT and US for planing Stanford US alone Where would go for a 2nd opinion for the Biopsy? Thanks

First ADT (hormone therapy) holiday since Dec22 ADT started 5Dec 2022 Leg weakness Started lifting weights etc Abiraterone started Aug 2023 + noticeable cognitive impairment

If it's 2 out of 100 and ADT increases the risk to 3 it's very different (and minor) then if it's 20 out of 100 and ADT increases it to 30. Anyone know the stats for this?

PSA 3 months post SBRT and while still on ADT was 0.09. PSA 6 months post SBRT, 1 month post ADT was 0.19. PSA today, 9 months, 1 week post SBRT, 4 months post ADT 0.59.

Summary Paragraph: The study examines testosterone recovery (TR) in prostate cancer patients undergoing androgen deprivation therapy (ADT) in conjunction with radiotherapy, as assessed across multiple randomized trials by the MARCAP Consortium.

If your doctor suggests ADT for you and you're not metastatic, PLEASE think long and hard before agreeing to it.

I've had my two years on ADT, and now I'm 6 months into my "vacation" (iADT) PSA has hit 2.0, and the plan is to restart ADT when it hits 5.0. Assuming there are no complications, I'm okay with that plan.

Dad has been on orgovyx ADT since 3 weeks. Since 3-4 days he complains of not getting proper sleep like earlier. Does ADT cause this ?

I don’t recall any such after-effects from my previous ADT injections; whether Lupron or Eligard. Maybe my goofy old brain just forgot! Was my experience yesterday unusual? Sorry to bother y’all with such a trivial question 😉