Experiences with

Androgen deprivation therapy (ADT)

But now I'm wondering (1) if it's a SE of ADT, and (2) if it might improve now that I'm off ADT. Doubling down on the Collagen powder, Genacol, Turmeric. Hopefully, it will improve post-ADT. Any advice would be welcome.

At 24 months, OS was 66% for APA+ADT, compared to 55% for enzalutamide+ADT and 59% for abiraterone+ADT.

Finally, BPA should be performed for the entire duration of the ADT as the risk of fracture has been shown to increase with increasing duration of ADT. A new DEXA should be performed at the end of ADT to evaluate whether to continue treatment with BPA.

The ARANOTE trial was a randomized, double-blind, placebo-controlled study that evaluated the safety and efficacy of darolutamide plus ADT compared to placebo plus ADT in patients with mHSPC. https://prostatewarriors.com/2024/11/22/fda-accepts-darolutamide-plus-adt-snda-for-mhspc-treatment/

Extracapsular extension puts me in high risk category, so radiation treatment and ADT prescribed, with 1st gen Lupron clone. ADT starts early 2024, and radiation treatment performed June-July 2024 (20 sessions). ADT drops PSA to 0.018. 5. Onco prescribes 1.5 years of ADT.

What I'm unsure of is how how long before the psma scan do I have to take the ADT. Is it 1 week, 2 weeks, or 3 weeks? In other words, how long does it take for psma expression to peak after after starting ADT?

https://prostatewarriors.com/2025/01/06/phase-2-adaptive-adt-and-docetaxel-trial-for-mcspc/

A treatment paradox has recently come to light in prostate cancer: Blocking testosterone production halts tumor growth in early disease, while elevating the hormone can delay disease progression in patients whose disease has advanced. The inability to understand how different levels of the same hormone

Hi everyone, I think my ADT holiday I s getting short.I had SBRT on spot found in the iliac bone and than 18 months of ADT( no Zytiga yet).stopped ADT and only almost 4 months my PSA is rising ( 0.038) from <0.006 on May.The problem is that the Testosterone is less than 50. Castration resistance?

Has anyone been recommended / experienced some kind of ADT break with bone mets? Thank you.

My take here is: patients receiving darolutamide and ADT had a 46% reduction in the risk of disease progression or death compared to those on ADT alone (hazard ratio [HR] 0.54).

RP in 3/20, 9/44 postive lymph nodes post surgery PSA 1.7 PSMA done 5/20 one lymph node in Paraaortic showed up Radiation to whole pelvic bed with a boost to Paraaortic lymph node ADT 3 years, Appalutamide for 2 years (last ADT shot March of 2023) 14 months undetectable after stopped ADT 9/24

For mHSPC, ADT + docetaxel + darolutamide demonstrates less cardiotoxicity than ADT + decetaxel + abiraterone acetate + prednisone due to a lower risk of hypertension and arrhythmias from decreased mineralocorticoid excess.

I have been reading about Testosterone recovery after ADT, and trying to get some information about the likelihood of never recovering my T at age 77 after 2 years of ADT. Is there anybody out there in their mid 70's who have completed their ADT and recovered their T?

I read here some do enzalutamide alone without ADT or bicalutamide alone and have low psa numbers even with their testasterone being very high Whereas for those on ADT and ARSi both they say the testosterone numbers should be low and lower the better. Can someone throw some light on this 😊

I have been on ADT vacation for 10 months now.(stage 4 with starting PSA 2250 in 2019). 2019 started on ADT and PSA has been undetectable 4 months after I started and is still. Testosterone less than 40(undetectable) and still is.

I would prefer SBRT but without ADT as I had polio at 1 years old. My muscle mass is very weak in my left leg, do worried 4-6 mo of ADT would cause too much damage. Heard outcomes are good for SBRT without ADT. Any advice? Wife is pushing surgery, but I am not sure. Thanks

Both Stanford and UCSF want to do 2 sessions of HDRB without ADT (They feel with my pathology and low decipher ADT would not provide much benefit) Uses CT and US for planing Stanford US alone Where would go for a 2nd opinion for the Biopsy? Thanks

My uro says they shoot for 20 T with ADT.

I was prescribed a treatment of low dose brachytherapy, external radiation, and ADT.