Experiences with

Androgen deprivation therapy (ADT)

Have any of you taken literature on the PATCH trial to your main cancer doctor (whether urologist, RO, or MO) and convinced the doctor to switch you from ADT to estrogen patches (for those already on ADT), or start you on estrogen patches instead of ADT (for those about to start ADT)?

Freedom (in English), libertà (in Italian), libertas (in Latin)...this trial will try to prove if apalutamide + intermittent ADT is non inferior to apalutamide + continuous ADT....

Many new posters here ask for advice for advanced mHSPC cases regarding ADT vs RT. This is a fairly recent video presentation that reviews several trials and lays out scenarios. Starting with delayed ADT (ie wait until RT-treated PCA comes back), through RT & ADT.

W 2025.04 zacząłem radioterapię na lożę i węzły chłonne i zatrzyki z Leuperliny tj ADT. Po radioterapii i zastrzyku PSA spadłodo poziomów nieoznaczalnych tj PSA 0.004.Od roku przyjmuję ADT A mój lekarz chcę żebym był na ADT jeszcze dwa lata! Myślę czy nie zacząć BAT nawet bez jego zgody.

Is there ways to keep PSA levels low during ADT break? Besides injections like trimix is there anything that combats ed especially when on ADT.?

+ ADT.

From prior posts you might have gleaned I am struggling with the ADT decision. To solidify my final decision I had the Artera Prostate Test (https://artera.ai/for-patients) and I tested negative. This means I am unlikely to benefit from ADT.

Anyone else on ADT experiencing very thin and fragile skin that tears like paper? Is it the ADT or just old age (I’m 74) or both? Any suggestions to make it better? Thanks.

Far and away, the #1 complaints across all Pc forums is ADT, but the chance of biochemical FREE survival at 36 mos is already 80% -ish +/- depending on Gleason risk without ADT and ADT turns that 80% into 90% - ish but at what I fear to be an extreme impact on quality of life.

At 24 months, OS was 66% for APA+ADT, compared to 55% for enzalutamide+ADT and 59% for abiraterone+ADT.

) and 52 to receive enzalutamide plus ADT and SBRT.

Finally, BPA should be performed for the entire duration of the ADT as the risk of fracture has been shown to increase with increasing duration of ADT. A new DEXA should be performed at the end of ADT to evaluate whether to continue treatment with BPA.

Too late for me as I'm just coming up to my 20th month of ADT!

So, if one's PSA has been low for a fair bit and one's T is low, what is the point of staying on ADT and continuing to expose oneself to the many potentially negative side effects of ADT and reduced QOL ??? Thanks for your input !

But now I'm wondering (1) if it's a SE of ADT, and (2) if it might improve now that I'm off ADT. Doubling down on the Collagen powder, Genacol, Turmeric. Hopefully, it will improve post-ADT. Any advice would be welcome.

A friend of mine had treatment for oligo metastatic disease and has been placed on ADT treatment for 2 years afterwards before he started a ADT pause. (Supported by his medical team) He has been off the ADT for a little over a year now and his PSA has steadily increased to around 4,0.

Hi , New to this forum, 64 YO Gleason 9 . no mets . Did 28 Radiation treatments completed Nov 24, Been on Eliguard since sept 2024. I'm on a 2 year sentence...... Question, How do I know what the best Drug is for this? I'm thinking of switching to Orovyx and have discussed this with the NP who

Interesting study on the importance of post-ADT testosterone recovery for long-term health. I’m curious if this suggests that 18 months of ADT rather than 24 is equally effective for my node-positive 4+3 disease.

In 2019 I used tE2 for ADT and Zytiga to mop up any remaining biosynthesis. T held undetectable and so did PSA. I'm thinking of adding it to pBAT. Thoughts?

My husband is on ADT and Orgovyx and Flomax and Cyalis. His glucose which was 90-100 range rose to 130 this month even though he’s lost weight and eats healthy. I know ADT can do that. Any suggestions appreciated to combat rising glucose while on the meds.