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Androgen deprivation therapy (ADT)
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ADT "vacation" terminology questions
I see a lot of posters here who say they do
ADT
"vacations." Are there any circumstances when NCCN SoC indicate cessation or interruption of
ADT
and abi? The term "vacation" implies an inevitable return to
ADT
. Do you wait for rising PSA or a fixed time to go by?
I see a lot of posters here who say they do
ADT
"vacations." Are there any circumstances when NCCN SoC indicate cessation or interruption of
ADT
and abi? The term "vacation" implies an inevitable return to
ADT
. Do you wait for rising PSA or a fixed time to go by?
Derf4223
in
Advanced Prostate Cancer
22 days ago
Thoughts on ADT with sRT?
Temporary
ADT
can lead to permanent testosterone loss in up to 30% of men. So when we compare sRT-only patients to sRT+temporary
ADT
, what we're really looking at is a mixed cohort, a part of which are effectively being treated with sRT+permanent
ADT
.
Temporary
ADT
can lead to permanent testosterone loss in up to 30% of men. So when we compare sRT-only patients to sRT+temporary
ADT
, what we're really looking at is a mixed cohort, a part of which are effectively being treated with sRT+permanent
ADT
.
ElRanchoDePoisonIvy
in
Advanced Prostate Cancer
19 days ago
Xtandi (enzalutamide) +ADT slows metastases in recurrent men
We recently saw that
ADT
+Erleada (apalutamide) slows progression compared to
ADT
alone.
We recently saw that
ADT
+Erleada (apalutamide) slows progression compared to
ADT
alone.
Tall_Allen
in
Advanced Prostate Cancer
1 month ago
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However, he wants do the SRT w/o
ADT
. His rationale is that if we do
ADT
concurrently, there's no way to tell if the SRT was working. Plus, he says that if the SRT fails, then I'll be in the same boat with
ADT
anyway, so why not wait?
However, he wants do the SRT w/o
ADT
. His rationale is that if we do
ADT
concurrently, there's no way to tell if the SRT was working. Plus, he says that if the SRT fails, then I'll be in the same boat with
ADT
anyway, so why not wait?
ElRanchoDePoisonIvy
in
Advanced Prostate Cancer
2 months ago
Confused about doublet therapy vs triplet therapy for prostate cancer
However, the clinical trial articles i've read regarding triple therapy, they don't compare
ADT
+ AR verse (doublet)
ADT
+ AR + chemo (triplet), they only compared
ADT
+ Chemo verse
ADT
+ AR + chemo.
However, the clinical trial articles i've read regarding triple therapy, they don't compare
ADT
+ AR verse (doublet)
ADT
+ AR + chemo (triplet), they only compared
ADT
+ Chemo verse
ADT
+ AR + chemo.
Jdhanoa
in
Advanced Prostate Cancer
2 months ago
Pluvicto after long time androgen deprivation therapy
[i]Continuous long-term
ADT
significantly reduces the visibility of castration-sensitive PC on PSMA PET/CT. If the objective is visualization of the maximum possible extent of disease, we recommend referring patients for PSMA PET/CT before starting
ADT
.
[i]Continuous long-term
ADT
significantly reduces the visibility of castration-sensitive PC on PSMA PET/CT. If the objective is visualization of the maximum possible extent of disease, we recommend referring patients for PSMA PET/CT before starting
ADT
.
MyDad76
in
Advanced Prostate Cancer
21 days ago
ASCO 2023 Poster: Androgen-deprivation therapy and risk of dementia in patients with prostate cancer:Clinical outcomes from real-world data.
Conclusion: This is the largest real-world study describing the association between
ADT
and the risk of dementia, including over 600 thousand prostate cancer patients. The risk of dementia was significantly higher in patients on
ADT
, with a 60% increased risk.
Conclusion: This is the largest real-world study describing the association between
ADT
and the risk of dementia, including over 600 thousand prostate cancer patients. The risk of dementia was significantly higher in patients on
ADT
, with a 60% increased risk.
rsgdmd
in
Advanced Prostate Cancer
3 days ago
ADT and Testosterone Recovery
https://www.urotoday.com/video-lectures/asco-gu-2023/video/mediaitem/3299-testosterone-recovery-in-patients-with-prostate-cancer-treated-with-radiotherapy-plus-
adt
-tanya-dorff.html I am 5 months into 24 months of
ADT
(Lupron) coupled with Radiation therapy.
https://www.urotoday.com/video-lectures/asco-gu-2023/video/mediaitem/3299-testosterone-recovery-in-patients-with-prostate-cancer-treated-with-radiotherapy-plus-
adt
-tanya-dorff.html I am 5 months into 24 months of
ADT
(Lupron) coupled with Radiation therapy.
OldVTGuy
in
Prostate Cancer Network
2 months ago
Vacation time again
We decided to follow the original plan of intermittent
ADT
and I’m starting another
ADT
vacation. This round of
ADT
had started with minimal SE’s but in the last month or so it’s gotten worse. My energy level has noticeably decreased and the hot flashes have noticeably increased.
We decided to follow the original plan of intermittent
ADT
and I’m starting another
ADT
vacation. This round of
ADT
had started with minimal SE’s but in the last month or so it’s gotten worse. My energy level has noticeably decreased and the hot flashes have noticeably increased.
fireandice123
in
Advanced Prostate Cancer
1 month ago
Follow up at Duke !!
He confirmed that PSMA PET is now SOC and would have been indicated prior to
ADT
. Also referenced the STAMPEDE info and affirmed that zytiga in addition to
ADT
is recommended. We were only started on
ADT
one year ago.
He confirmed that PSMA PET is now SOC and would have been indicated prior to
ADT
. Also referenced the STAMPEDE info and affirmed that zytiga in addition to
ADT
is recommended. We were only started on
ADT
one year ago.
warrior22
in
Advanced Prostate Cancer
2 months ago
Does a biopsy of a recurrent LN will help in anything ?
Hi all, short version of my Bio: RP in 2019 followed by 33 sessions SBRT with short term
ADT
(6 mo). Reccurence in 2021, SRT to one LN in 2022, 5 sessions with short term
ADT
(6 mo). As soon the
ADT
stopped the PSA started rising, it´s 0.53 now.
Hi all, short version of my Bio: RP in 2019 followed by 33 sessions SBRT with short term
ADT
(6 mo). Reccurence in 2021, SRT to one LN in 2022, 5 sessions with short term
ADT
(6 mo). As soon the
ADT
stopped the PSA started rising, it´s 0.53 now.
CarlosBrasil
in
Advanced Prostate Cancer
2 months ago
Testosterone Recovery in Patients With Prostate Cancer Treated With Radiotherapy Plus ADT
[i]
With six months of androgen deprivation therapy (
), 75% of men recovered normal testosterone levels, but the median time to recovery was 18 months. With 18 months of
ADT
, only a quarter of men recovered to normal levels, and the average time was five years. [/i]Dr.
[i]
With six months of androgen deprivation therapy (
), 75% of men recovered normal testosterone levels, but the median time to recovery was 18 months. With 18 months of
ADT
, only a quarter of men recovered to normal levels, and the average time was five years. [/i]Dr.
SierraSix
in
Advanced Prostate Cancer
2 months ago
Intermittent ADT
It's a difficult decision. Here are things to consider: https://www.prostatecancer.news/2023/04/intermittent-adt.html
It's a difficult decision. Here are things to consider: https://www.prostatecancer.news/2023/04/intermittent-adt.html
Tall_Allen
in
Advanced Prostate Cancer
1 month ago
Amar Kishan, MD, on Optimal Sequencing of ADT With RT in Nonmetastatic Prostate Cancer
The patients were treated with RT and short-term neoadjuvant/concurrent
ADT
(n=6,325) or concurrent/adjuvant
ADT
(n=1,084), and outcomes were examined by RT field size.
The patients were treated with RT and short-term neoadjuvant/concurrent
ADT
(n=6,325) or concurrent/adjuvant
ADT
(n=1,084), and outcomes were examined by RT field size.
Yearofthecow
in
Prostate Cancer Network
3 months ago
adt & radiation
Hey everyone, just discovered this site. Great info and support. I had RP in August of 2022. First psa test was 0.1, month later psa 0.8 month later psa 0.22 Psa remained at 0.22 for next 3 months.My urologist who did RP said it could be "reactive lymph nodes". A CT scan and bone scan revealed nothing
Hey everyone, just discovered this site. Great info and support. I had RP in August of 2022. First psa test was 0.1, month later psa 0.8 month later psa 0.22 Psa remained at 0.22 for next 3 months.My urologist who did RP said it could be "reactive lymph nodes". A CT scan and bone scan revealed nothing
Gunner412
in
Advanced Prostate Cancer
2 months ago
Xtandi (enzalutamide) alone is superior to ADT alone at preventing metastases in "high-risk" recurrent men
performed significantly better than
ADT
alone (+ placebo).
performed significantly better than
ADT
alone (+ placebo).
Tall_Allen
in
Advanced Prostate Cancer
3 months ago
ADT and ED Meds?
I am wondering if anyone on
ADT
is taking an ED med and what effects, if any, it has had? Is it less than ideal to throw this on the pile with
ADT
+ ARSi?
I am wondering if anyone on
ADT
is taking an ED med and what effects, if any, it has had? Is it less than ideal to throw this on the pile with
ADT
+ ARSi?
FinnO
in
Advanced Prostate Cancer
4 months ago
ADT Recommendations
I'm probably looking at starting salvage radiation soon with 4-6 months of
ADT
. The doc suggests starting with Casodex and then two sequential Lupron shots. Is there a better way to do
ADT
for that period?
I'm probably looking at starting salvage radiation soon with 4-6 months of
ADT
. The doc suggests starting with Casodex and then two sequential Lupron shots. Is there a better way to do
ADT
for that period?
ElRanchoDePoisonIvy
in
Advanced Prostate Cancer
2 months ago
ADT and paroxysmal afib
Are there risks having
ADT
with respect to paroxysmal afib
Are there risks having
ADT
with respect to paroxysmal afib
pd63
in
Advanced Prostate Cancer
2 months ago
Worrying study on long-term ADT (esp Enza)
Is this NED affect of long-term
ADT
common knowledge? If so, is it particular to Enza? 2. Has anyone ever just stopped
ADT
and, if so, what was the impact on their PSA? 3. Does anyone have any alternatives to Enza (I was already coming off it because of the horrible, exhausting SEs)?
Is this NED affect of long-term
ADT
common knowledge? If so, is it particular to Enza? 2. Has anyone ever just stopped
ADT
and, if so, what was the impact on their PSA? 3. Does anyone have any alternatives to Enza (I was already coming off it because of the horrible, exhausting SEs)?
CrocodileShoes
in
Advanced Prostate Cancer
2 months ago
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