OS versus Testosterone Nadir - 4

[janebob99]

This plot shows the Overall Survival Probability after RT and ADT, for Advance Prostate Cancer men, comparing different levels of testosterone nadir (< 10 ng/dL, 10-20, and 20-50,

The best outcomes are significantly associated with a lower testosterone nadir ( < 10 ng/dL).

At 11 years, the OS probability = 95% for T-nadir <10 ng/dL, compared to only 70% for T-nadir = 10-20 ng/dL. That's a significant difference !

This may be well-known to many of you, but it was new to me.

The prior definition of castration being < 50 ng/dL probably needs to redefined to < 20 or < 10 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).

Ref: (2024) bjui-journals.onlinelibrary...