Great PSA results and going back on cBAT

[KocoPr]

As you know from my recent BAT posts I had to stop due to Kidney Stones, gout and high uric acid at 5.6 along with a big spike in PSA from 1.4 to 6.36 in 30 day period while on High T.

I contribute it to not drinking enough water and a PSA spike causing high uric acid.

In any event this was fortuitous as ER non contrast scans showed enumerable Mets in abdomen including spine and iliac. 1 week later a PSMA scan showed Bone mets on L4 and iliac plus one new Lymph. It also revealed I have no more lymph mets above abdomen i.e., clavicle and media stinum.

I am HSPC and have been doing BAT for 15 months successfully before this uric acid episode.

I set my goal to go back on Orgo/Daro Oct 2-2024 till I reached PSA of 0.05 which after 3 1/2 months I finally reached that goal.

I also convinced my MO to start E2 patch at 0.025mg weekly to reduce ADT side effects which worked perfectly and kept my E2 levels right where I wanted them at 17-22 pg/dl without increasing my PSA! That was huge and made me very happy.

Next step is to stop E2 patch, clear daro for 6 days staying on Orgo and hen stop Orgo and start High T on Jan 20-2025.

I will modify my BAT to T-cypionate weekly at 300mg instead of 400mg bi monthly.

I will continue this for 5 weeks then on 6 & 7th week I will give cypionate a chance to drop my T before I transfer over to every other day of T-propionate for weeks 8 & 9.

Then I will give a day to clear T and start my 30 day Orgo/Daro cycle with E2 patch when my E2 level drops below 10pg/dl.

I will monitor quite often as this is a new regiment and so I can get a handle on my T, PSA, E2 levels.

I will also reserve the right to terminate High T at any time due to PSA levels I am not comfortable with (to be determined). I will also extend or shorten Daro/Orgo cycle if satisfied with PSA reduction levels.

Flexibility and monitoring is the key for me.

The idea is to stay hormone sensitive.

[Mascouche]

All 3 of your issues are uric related. What I do to lower the uric acid and prevent melt kidney stones is to start my day with a glass of water in which I put the juice of a whole lemon plus a large soup spoon of apple cider vinegar and another soup of olive oil. It doesn't just prevent kidney stones, it actually melted a 3mm stone that I had prior to starting this remedy. The 3mm stone which was previously shown on a scan was no longer present in subsequent scans.

Also, do not eat for an hour, preferably two hours, after drinking that concoction because it will momentarily dilute your stomach acid which is needed to be to properly digest your next meal.

[KocoPr in reply to Mascouche]

Yes i read one of you post about this and i have been doing similar except it was 20 minutes before meal and i didn’t see the olive oil in your previous post.

Anyways all is good now with a uric acid of 3.3

[Maxone73]

GREAT!!!!

[MateoBeach]

well wishing you the best with this re-trial KocoPr. You have it well thought out and makes sense to me. However you did have progression on that last cycle even with the Urate issues it might not be favorable for you anymore. CloseMonitoring will tell. If PSA take off again you could consider longer ADT and darolutamide cycles to return PSA to near castrate Levels. No one knows optimal cycling strategy. One month high T and one month castrate appear minimal to reset AR activity anf cMYC. BUT LONGER mojo” ql mo

Xhwc

[MateoBeach in reply to MateoBeach]

That did not complete. Meant that longer cycles Might be better for some to reset AR activity and cMYC levels in prep for next high T cycle. Paul

[KocoPr in reply to MateoBeach]

Did you mean prep for next ADT cycle?

From my understanding high T reduces cMYC and can change the ratios of AR monomers and dimers to more dimers which will reduce bad translation.

I am pretty sure thats why high T works.

[MateoBeach in reply to KocoPr]

Yes. But ARs get down-regulated as high T continues. That is one reson why a low T/castrate cycleis needed to reset for next high T cycle. That is the theory I am operating under anyway.

[KocoPr in reply to MateoBeach]

Thanks Paul,

I will monitor closely. I anticipate progression while on high T which tells me my beasty likes androgen, i just have to be ready to shut it down when it gets to my oh crap factor which i haven’t determined yet but im think once PSA hits 1.0 +- 0.2 i will shut T down.

When you say progression do you mean to the bones? Ya that was an eye opener and an inevitable step. MO said the ADT will definitely kill the two bone mets.

[Mrtroxely]

What was the cause of uric acidAnd what effects does high uric acid do

[KocoPr in reply to Mrtroxely]

The cause of uric acid i believe was a combo of high T and not drinking enough water.

From what i have read and understand is high uric acid causes inflammation and an acidic environment which is ideal for cancer, but also high tumor burden can also cause the high acidic environment causing high uric acid. Also a lot of dying cells can cause high uric acid. So you can see a correlation. There are plenty of papers on the subject. You can also pick up the book “drop acid” which is ok but i would get it at the library for free.