Researchers found that androgen receptor (AR) extrachromosomal DNA (EcDNA) is a key factor in treatment resistance for advanced prostate cancer. AR EcDNA leads to overexpression, disrupting traditional treatment responses, and presents new therapeutic targets for improved outcomes.
Extrachromosomal DNA (EcDNA) is DNA that exists outside the main chromosomal structure. It often forms circular loops, can carry genes, and plays a role in gene amplification and tumor progression.
Supraphysiological Androgens [SPA] Promote Tumor Suppressive Activity of the AR Through cMYC Repression and Recruitment of the DREAM Complex
Update on Prostate Cancer Vaccines from Previous Posts done over the last few years... and a new one...Warming Up the Cold: A New Hope for Immunotherapy in Prostate CancerUpdate on Prostate Cancer Vaccines from Previous Posts done 1 year agoCancer and Atherosclerosis targeting, A New Blood test to guide treatment, Targeting drug resistance in PCa
