News from white button mushrooms!

[Maxone73]

Do you remember the article I posted about the research on white button mushrooms slowing down PCa? (I must be careful because I keep writing white bottom!) .

Here are some more precise data about the quantity they used for their experiments:

They derived a single white button mushroom tablet from 6 g of fresh mushrooms. Patients in clinical trial consumed between 16 to 28 tables per day. “Imagine a basket from Costco (24 ounces),” Wang said. “Patient consumed one-quarter (6 ounces) or one-third (8 ounces) of a basket of those mushrooms each day.”

EDIT: derived from 6g of fresh mushrooms as in extracted from 6 grams of fresh mushrooms. But eat them COOKED if you want to avoid the extract and go for the mushrooms!

healio.com/news/hematology-...

[Cackalacky_cyclist]

color me confused; the explanation does not seem to coincide with the math. If one tablet is from 6g of mushrooms and each patient takes 16 to 28 tablets per day then that’s equivalent to 96g - 168g, or 4 to 7 Costco mushroom packets. Per day. Holy shitake Batman!

[Maxone73 in reply to Cackalacky_cyclist]

I think in grams, here where I live the common format for fresh white button mushrooms is 400-500 grams per pack, 1 tablet = 6 grams of mushrooms, so with one pack you do 2 to 4 days

[Cackalacky_cyclist in reply to Maxone73]

Ah, my dyslexia strikes again - I read "24g" instead of "24 ounces". So I have a little crow with my mushrooms, yum!

[petabyte in reply to Maxone73]

I wonder if they made the active ingredient more bioavailable with the processing. And if cooked would work (I guess not).

[Maxone73 in reply to petabyte]

They used boiling water to make the extract. If I remember in the original article I posted some time ago the procedure was explained

[petabyte in reply to Maxone73]

Then maybe cooking in butter might work 😉

[podsart]

soy what manufacturer and dose should we be taking? I saw some Amazon products that were sold out.

[Maxone73 in reply to podsart]

I will be eating them 3-4 times per week in big quantity, so I have not checked if there are any brands or not

[GardenReno in reply to Maxone73]

I buy my mushroom powders from bulk supplements in the USA. I take about 12-14g per day heated through with my millet for breakfast to help activate them. Even though I’m advanced stage 4 I reckon they help both gut and immune system as well as PSA

[KocoPr]

Max, something doesn’t sound right. I hunt and make mushroom medicine for myself. I have a dozen books on mushrooms and half are medicinal books and they all use extracts of mushrooms for medicinal qualities. Generally but not always the water extracts are the most beneficial for disease. For the WBM it uses a water extract for the PCa fighting ability.

The authors of your article do not understand that the trial used WBM extracts.

Here is the article from NIH on the trial which states extracts of WBM.

pmc.ncbi.nlm.nih.gov/articl...

White Button Mushroom (Agaricus bisporus) Disrupts Androgen Receptor Signaling in Human Prostate Cancer Cells and Patient-Derived Xenograft

By the way it is toxic to eat large quantities of uncooked WBM.

What you really want to do is drink the thoroughly boiled water of WBMs.

Here is a good website on making water extractions of mushrooms.

birchboys.com/pages/mushroo...

The Science of Mushroom Tincture Making

Part1: Hot Water Extraction.

[Maxone73 in reply to KocoPr]

Not following you. The tablets were made from the water extract, the people cited in the article are the same of the study you posted. When they say 6 grams of mushrooms they are saying that there is the same quantity of the active substance as in 6 grams of mushrooms, not that the tablets are made of raw dried mushrooms.

But you are right, this could be misunderstood.

I personally think I will find more enjoyable eating them (cooked, not raw) but that's my personal preference! 😜

[Don717 in reply to Maxone73]

...and on top of a nice steak! Steak. Man I haven't had a steak in....I can't remember.

[Maxone73 in reply to Don717]

😂😂😂

[KocoPr in reply to Maxone73]

It still isn’t water extracted when cooked and eaten but it certainly is better cooked in olive oil, butter, onion and garlic with paprika then finished in a heavy cream for sauce and toped with thyme. Of course on top of a big fat jiucy steak with smashed cauliflower. Oh and a nice red wine!

[Maxone73 in reply to KocoPr]

Dammit it was healthy till the heavy cream! OK also for the wine, an Amarone possibly (it costs relatively less here as it's a local product). But really, what could I add apart from garlic and pepper (and paprika)...parsley? I would love to create an even more "powerful" potion 😀

[JohnInTheMiddle]

Just for clarification, I understand that commonly sold white mushrooms in North America are the same mushroom as white button mushrooms, but just larger and more mature.

Couple of questions ...

1. Frying larger white mushrooms is okay in terms of the substance we're interested in?

2. Is this whole thing still relevant in terms of high volume metastatic PCa?

3. In terms of the volume of the substance we are interested in, practically speaking if one wants to just eat mushrooms and not buy an extract, what is the volume of mushrooms one should apparently on a daily or weekly basis?

Thanks Max,

John

[Maxone73 in reply to JohnInTheMiddle]

Hi!

"I think in grams, here where I live the common format for fresh white button mushrooms is 400-500 grams per pack, 1 tablet = 6 grams of mushrooms, so with one pack you do 2 to 4 days" Basically the main researcher said that while he still cannot suggest mushrooms as a treatment, adding them to your diet can only improve your immune system. Kokopr said it's not exactly the same to eat them cooked and getting the extract (which is obtained using boiling water). The scientific name of that kind of mushrooms is Agaricus bisporus.

They are talking about tumor growth, not prevention, so I suppose it would work for metastatic patients as well but not sure if they would have the same amount of efficacy.

Preclinically: "In murine models, WBM treatment significantly suppressed tumour growth with a reduction in both the number and function of MDSCs, which in turn promoted antitumour immune responses mediated by T cells and natural killer (NK) cells. In patients, after consumption of WBM tablets for 3 months, we observed a decline in circulating polymorphonuclear MDSCs (PMN-MDSCs), along with an increase in cytotoxic CD8+ T and NK cells. Furthermore, single immune cell profiling of peripheral blood from WBM-treated patients showed suppressed STAT3/IRF1 and TGFβ signalling in circulating PMN-MDSCs. Subclusters of PMN-MDSCs presented transcriptional profiles associated with responsiveness to fungi, neutrophil chemotaxis, leukocyte aggregation, and regulation of inflammatory response. Finally, in mouse models of PCa, we found that WBM consumption enhanced the anticancer activity of anti-PD-1 antibodies, indicating that WBM may be used as an adjuvant therapy with immune checkpoint inhibitors."

[JohnInTheMiddle]

So other than fried mushrooms are really delicious, we can't say that there they are a fantastic PCa adjunct therapy, at least yet. Couldn't hurt I guess.

[Maxone73 in reply to JohnInTheMiddle]

Your microbiome will thank you! But also the small clinical trial they ran is looking good!!

[petabyte]

I was wondering about the difference between white and brown mushrooms. Sounds like the same (and portobello).

chatgpt.com/share/67a88bd3-...