Fibromyalgia Action UK
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Mix of meds

Hi all,

i am taking 25mg of amitriptyline each night and during the day dihydrocodine, naproxen and methacarbamol when needed.

I have been getting bad leg pains and restless legs at night again and was given pramipexole for this which i only tried once.

Is anyone else on this sort of combo of meds or know if its safe to take pramipexole and amitriptyline?

I used to use a website that showed interactions between meds but cant remember what it was called!



5 Replies

hi, holly, there is a site called where you can list your meds and see if there are any contraindications,

hope this is of use



Hi Holly,

The best thing you can do is pop into a local branch of Boots, and ask at Pharmacy for a medication check up.

It's free, but you need to take a list of your meds with you.

The pharmacist will check that your prescription is safe for you, and will contact your GP if there is a problem. I have always used this service, and it's excellent!

I think other pharmacies do the same, but I'm not sure which ones.

Moffy x


Hi Holly,I used to take Amitriptyline and Gabapentine they really help with painful,restless legs.I no longer take the Amitriptyline as I'm on Tramadol for pain and they don't mix.


Ive heard from a few people they take gabapentin and amitriptyline, my go took me ofd gabapentin to start amitrptyline as he said i couldnt take the 2 but i think i need to ask about this as it seems many people do



Is the Ami helping? I ask because research does not really support its use for Fibro longterm as it can end up either with effectiveness wearing off and/or with side effects becoming problematic.

Pramipexole is actually a recommended treatment for Fibro, but the dose needed for this is typically higher than that used for RLS, and initial side effects can be very difficult.


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