I had: PSA 30, Gleason 10, PCa Stage 4 localized to pelvic region.
Treated with IMRT radiation + Eligard + Abiraterone. PSA undetectable.
Stopped Abiraterone due liver that hates it (liver is ok).
Will try Nubeqa, and may switch to Orgovyx after Eligard runs out in December.
While ADT starves the cancer, I am taking some food supplements to help with side effects. I tried to select "healthy" supplements that may fight prostate cancer as well.
I've included links to a paper on each. Any feedback welcome.
John actually my hospital advice is 80 grams protein and switch to plant based diet, 1/3 fruits, 1/3 veggies and 1/3 protein. Kind of hard to do constantly, if you want resveratrol eat red grapes
Resveratrol is rumoured to work well with Turmeric and ursolic acid, however my oncology pharmacist says the tumeric and resveratrol have a negative effect on aberaterone. Who knows, it's a minefield.
Taking food supplements may benefit you, depending on what and how much you take. Some can also be toxic at higher dosages. It’s often a guessing game .
Turkeytail and other mushrooms are purported to be helpful. I've started drinking Ryze coffee ryzesuperfoods.com/ in the morning. Mud/wtr coffee also contains these healthy mushrooms. mudwtr.com/
Rather than just throwing "Supplement" darts at the wall, I would talk to a good naturopath about your specific situation and let them make some recommendations just for you. I wish you the best.
I remember Cellophane............ It goes like this, Betty Davis speaking: "Peter, Peter why are you wearing those Cellophane shorts? I always knew you were crazing but now I can see your nuts".
(you guys must hate me..... but I just gotta or I won't be able to sleep tonight)
I know your post is a year old but I first heard about IP6 + Inositol Hexaphosphate today and when I did a search in the advance prostate cancer forum, your post was the only one mentioning this.
Since you are still active here, I guess I can safely assume that it did not cure you but I was wondering what was your experience with it. Have you found it to help you in any way?
***
I did ask Perplexity AI this question: What is the impact of ip6 inositol hexaphosphate on prostate cancer?
Here is its answer:
Based on the search results, inositol hexaphosphate (IP6) shows promising anti-cancer effects against prostate cancer in preclinical studies. Here are the key findings on the impact of IP6 on prostate cancer:
Inhibition of tumor growth and progression:
* IP6 inhibits growth of prostate cancer xenografts in animal models.
* It suppresses tumor growth and progression in the TRAMP (transgenic adenocarcinoma of mouse prostate) model.
*IP6 feeding reduces prostate tumor size and vascularity in mice.
Anti-angiogenic effects:
* IP6 treatment decreases tumor vascularity and angiogenesis.
Metabolic effects:
* IP6 interferes with glucose metabolism and membrane phospholipid synthesis in prostate tumors.
* It decreases expression of glucose transporter GLUT-4 and increases phospho-AMP-activated kinase levels.
Cell cycle and apoptotic effects:
* IP6 causes G1 cell cycle arrest and induces apoptosis in prostate cancer cells.
* It increases levels of pro-apoptotic proteins like PUMA, BIK/NBK, and NOXA.
* IP6 decreases levels of anti-apoptotic proteins MCL-1 and BCL-2.
Signaling pathway modulation:
* IP6 targets mitogenic and survival signaling pathways.
* It reduces phosphorylation of PI3K, PDK1, AKT, and GSK3α/β.
* IP6 decreases levels of ILK1 and cyclin D1.
Effects on cancer stem cells:
* IP6 shows potential to eradicate prostate cancer stem cell populations.
* It inhibits the formation of prostatospheres, indicating effects on cancer stem cell self-renewal.
Synergistic effects:
* IP6 enhances the killing of androgen-independent prostate cancer cells when combined with proteasome inhibitors.
Safety profile:
* IP6 is considered non-toxic when taken orally as a dietary supplement.
* Animal studies showed no adverse effects on body weight or food/water consumption.
These findings suggest that IP6 has multiple anti-cancer mechanisms and could be a promising candidate for prostate cancer prevention and treatment. However, it's important to note that most of these results come from preclinical studies, and further clinical research is needed to confirm its efficacy in humans.
*** End of AI answer
There are some articles about it but most of them are quite old:
Within a month of my last IMRT radiation treatment in Aug 2023, my PSA dropped to undetectable (from 26) and has remained there. In addition to dietary supplements, I get an Eligard injection every 90 days and daily Nubeqa.
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