Experiences with

Abiraterone

He was prescribed a Lupron injection along with 1000 mg of Abiraterone. However, he is experiencing significant vomiting with Abiraterone. Has anyone else had a similar experience? Any tips to manage this?

Am I correct that when a patient becomes resistant to either enzalutamide or abiraterone, or has to stop due to arrhythmia one cannot be substitued for the other? Other than docetaxel (chemo) are there other commonly used treatments after enzalutamide or abiraterone resistance?

74 yrs old, initial PSA 16. Biopsy Gleason 4+3 with mets to presacral lymph nodes as per PSMA scan. 45 radiation treatments ended Dec. 2 started Eligard Oct 8. December 23rd PSA 0.16, T <10. Urologist wants to add abi+ prednisone to Eligard for total of 24 months. Currently only minor SE with Eligard

The study, published on Nature, found that a combination of talazoparib and enzalutamide (TALA + ENZA) may be more effective than other PARP inhibitor combinations, such as olaparib plus abiraterone acetate and niraparib plus abiraterone acetate.

Combining nodularin-R with abiraterone resulted in synergistic inhibition of resistant cancer cells both in vitro and in vivo, indicating that nodularin-R might help overcome abiraterone resistance in CRPC.

I have been taking Zytiga with 5mg prednisone for 6years now I have had side effects of high blood pressure now I have low Potassium level of 2.7 .has anyone else had this issue. My kidney doctor said double the dose of potassium from 10meq to 20 each day and check level in on week. Oncologist said double

Truqap (capivasertib), an AKT inhibitor, combined with abiraterone and androgen deprivation therapy (ADT) has shown promise in treating men with a specific subtype of prostate cancer called PTEN-deficient metastatic hormone-sensitive prostate cancer (mHSPC).

He was On Abiraterone and Prednisone for exactly 3 years. Dr at City of Hope recommended adding Provenge and continuing Abi and Pres. Any success stories using Provenge with or after Abiraterone? His PSA is 0.029.

After PSA started to raise, the MO added Abiraterone 1000 mg. a day with 10 mg prednisolone to his treatment regimen with Zoladex (once every 3 month) and Zoledronic acid (once every month).

My husband has been on Abiraterone/prednisone for 10 months and Lupron for 12 months and recently has had an increase in his bilirubin 2.5. His MO has stopped the abiraterone temporarily and has ordered a sonogram of his liver/gallbladder and weekly monitoring of bloodwork.

In addition, olaparib offers decreased hypertension when superimposed on ADT + abiraterone acetate + prednisone for mCRPC treatment after prior androgen deprivation from mHSPC therapy.

I was on Lupron and Abiraterone + Pred for 2 years. I completed both in early June, so I am now 5+months post-ADT. My T is only now starting to return (was 32 last week). However, my cortisol levels are still very low.

He was on 3 month lupron shot + Abiraterone . Does this means that Abiraterone failed . what are the next steps ahead ? Thank you all for your kind suggestions and reply .

Commenced abiraterone 1000 mg & prednisone 10mg . Also zoladex implants every 3 months in Feb 2018. Pas down to 0.01 after 3 months. In 2022 I reduced dosage of abiraterone & prednisone by half due to the excessive cost of abiraterone (was self funding) and also strong fatigue side effects.

In our experience, enzalutamide is less effective if patients were previously treated with abiraterone AND they have high level of ctDNA. On the contrary, patients receiving docetaxel after abiraterone have similar outcomes regardless of their starting ctDNA level.

I’ve read some posts here that some guys may have been on abiraterone ten years I’m not trying to blow up the servers.

My MO is changing my off of Abiraterone to Xtandi and wants to add Talzenna to my regime. Reading the FDA report on this 'new med' is scary and wondering if anyone in the community has used it and what side effects it gave them. Thank you for your response.

How long does it take abi to start reducing PSA? I started 4 weeks ago and PSA is still rising.

This combination therapy is being compared to the use of abiraterone acetate and prednisone alone in patients with specific genetic mutations related to DNA repair.

At 24 months, OS was 66% for APA+ADT, compared to 55% for enzalutamide+ADT and 59% for abiraterone+ADT.