Experiences with

Abiraterone

" [2] "A Case of -Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest" [1] "By inhibiting CYP17, abiraterone can induce a state of mineralocorticoid excess, which is associated with profound hypokalemia.

A couple of months ago, I posted a note regarding my blood pressure increase after taking abiraterone for three years and my attempts to lower my BP: https://healthunlocked.com/advanced-prostate-cancer/posts/147513264/abiraterone-prednisone-eplerenone-and-blood-pressure This note is an update that reports

I have been on abiraterone for about a year and a half along with Lupron. I’m currently seeing a cardiologist because the last two weeks I’ve developed heart palpitations/arrhythmia.

I've read abiraterone does cause fatigue, Does he just have to learn to live with this? His prognosis is terminal and after Abiraterone doctors have said he'll just be moved to clinical trials. Any advice on dealing with the exhaustion?

But doesn't it seem to make sense to use one with long-term abiraterone treatment?

I saw some people commenting concerning Dr Luke Nordquist was adding darolutamide to abiraterone in his practice . Does anyone know about this

ESMO 2021: Abiraterone Acetate Plus Prednisolone With or Without Enzalutamide Added to ADT Compared to ADT Alone for Men With High-Risk Non-Metastatic Prostate Cancer: Combined Analysis From Two Comparisons in the STAMPEDE Platform

"Further, the risk of hospitalization for heart failure was greater in abiraterone acetate (HR 2.88 ...)." https://www.urotoday.com/conference-highlights/aua-2021-program/aua-2021-prostate-cancer/131969-aua-2021-comparison-of-the-cardiotoxicity-of-abiraterone-and-enzalutamide-in-metastatic-castration-resistant-prostate-cancer-using-real-world-data.html

I know I can get generic abiraterone from India which can be affordable. Only problem is my dad already has had abiraterone many years ago and I would like to add enzalutamide to radium 223 which has been proven safe and more effective.

I am also taking abiraterone. I tend to think the residual ADT in my system will continue to be effective for a month, especially when I’m also on abiraterone acetate (Zytiga).

As such, abiraterone metabolism creates its own competitor, in a manner of speaking... [by producing] 3-keto-5-beta abira abiraterone [which] ends up as an androgen agonist, thus potentially mitigating the antitumor potency.

M1, five bone lesions, mCRPC with PSA now doubling each month (currently at 1.7), after failure of abiraterone.

I was placed of abiraterone and ADT 6 months ago. I am an avid exerciser so I have not experienced any fatigue but I think I was noticing mild weakness. I decided to start weight lifting. My question is: Do I expect to get stronger or just slow the deterioration.

Grumpy, 78 and frail, has been on 5 mg of prednisone while taking half dose of abiraterone along with full dose of darolutamide. He starts Taxotere 3/1 so the doc stopped abiraterone and darolutamide for two weeks before Taxotere.

Status: I've been on only 250mg of Abiraterone daily, prednisone 5mg and stopped Lupron Depot injects last June 2021. August 2019 PSA 14.393... Dec 2019 PSA 1.100 ... Aug 2021 PSA 0.126 ... Dec 2021 PSA 0.156 and this years PSA Feb 24th 0.300 .. So Dec '2021 till Feb 2022 my PSA doubled.

Does any know or have experience with using a generic form of zytiga (Abiraterone)? Is there a medical difference between the drugs or concern the generic may not be as effective?

Second recommendation is 6-9 months of ADT with intensification, probably abiraterone again, but possibly abieraterone + app;utamide. I previously had 18 months of abiraterone with EBRT after unsuccessful RALP and it yielded 18 months of PSA <0.5.

Anyone need Abiraterone... Have an extra voil... Pls direct message me

I understand that it is not safe to stop prednisone abruptly but is it safe to stop abiraterone abruptly? Dad is suffering severe side effects and doesn't wish to continue. Many thanks!

Lupron and abiraterone + prednisone. PSA staying low and MRI shows cervical neck tumor hasn’t grown and maybe shrank. Even with not-much-fun ADT side effects, I feel blessed.