I am a 74 year old retired Pediatrician who knew nothing about prostate cancer prior to my diagnosis 17 years ago. Have soft tissue mets(lungs) and with a rising PSA after 7 years on ADT, I am about to start a new chapter. It has been and continues to be an interesting journey. These forums have been a great help.
Will post my data for those interested:
Bob Lederer: Diagnosed November 1996, age 56, bPSA 11.6, Gleason 6(3+3), T2a, Gland size 75gm, EBRT 2500Rads, Lupron x1, 98 I-125 seeds implanted in Seattle (Seattle Prostate Institute) by John Sylvester in April 98. Partin table prediction: 55% chance outside capsule.
Impotence after 2 years but responded well to Viagra. PSAs fell and had expected bump at 18 mos. All below 0.1 until 7 years out. June 2008, (11 years out) rising in a linear progression but accelerated doubling time from 12 months to 7 months. Currently 2.91.
August 1, 2008-Focal Cryoablation at the University of Colorado Urologic Cancer Center. Preop PSA was 4.2. Prostate size 18 gms on color Doppler.
PSAs rose post op so Bone Scan and CT ordered. Scan neg but CT showed Left Lower Lobe lesion in lung. CT/PET scan showed activity in lungs and thyroid. Hemithyroidectomy March 2009, benign tumor. April 15 scheduled lung biopsy. Found extensive small mets on pleura of left lung. Biopsy revealed PCA in mets with cells appearing very similar to original cellular description from 12 years earlier. PSA was 11.8 at time of biopsy.
ADT begun with Lupron on April 26. 2009.
Early 2014 PSA’s 0.3 until August=0.35. Sept0.45
Definite trend up.
Repeat PET scan, April 2014. No activity noted
Follow up Bone density in April, 2011 also normal
T =10. Baseline bone density normal and Vit D normal..
Current therapy is Lupron every 4 mos. Zometa every 6 months (IV infusion)
Taking multivitamins and a Vitamin D supplement daily.
Hot flashes present but tolerable till 2014.
Added Estradiol patch 0.225 mg weekly, April 2013 to control hot flashes. (Avoid sleep disturbance)
PSA rises are very slow. Currently 1.1 and doubling time is about 12 months so no change in therapy yet, though will discuss a new drug next month.
The photo is me celebrating Movember with my two youngest grandchildren. Their mustaches beat mine!