My father 78 years young diagnosed in 2014, Radical prostatectomy 2014, Radiation x18 treatment 2014-14, Lupron 2014-present. Tried bicludamide- to many side effects. With Lupron PSA undetectable 2015-December 2016. Jan 2017 PSA 0.09 and doubling time 1 month. Mayo Clinic scans Jan 2017 small “glowing” pelvic node. Scan 2017, August 2017 PSA 3.5 Mayo C-11 scan -many lymph node metastasis from pelvic to infraclavicular areas. Option to begin chemo or Xtandi. September 2017 Xtandi started. PSA continued to rise. After three months of trial he failed on Xtandi we went for a rescan at Mayo clinic. This scan showed lymph node progression. There was also questionable neuroendocrine prostate cancer disease. January 2018 PSA 14.5 and jevtana and carboplatin every 21 days. PSA begin to increase by 1 to 2 points every three weeks. Current PSA 21.8. CT scan done showing minimal progression of lymph node disease but metastasis to spine and pelvic bone. Total of four rounds of chemo done with Jevtana and carboplatin. Gardent 360 blood test and biopsy completed three weeks ago. We are now awaiting the results and stains of the biopsy. My father’s medical oncologist Based on his pathology reports and genetic mutations will decide if my father will go on with Keytruda or will qualify and get excepted to the trial use of Optiva and Cabozantinib. Anyone have any experience with these medications and prostate cancer resistant to all of the treatments thus far?