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Advanced Prostate Cancer
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Chemo failed- Anyone with experience on Cabozantinib and Opdivo?

My father 78 years young diagnosed in 2014, Radical prostatectomy 2014, Radiation x18 treatment 2014-14, Lupron 2014-present. Tried bicludamide- to many side effects. With Lupron PSA undetectable 2015-December 2016. Jan 2017 PSA 0.09 and doubling time 1 month. Mayo Clinic scans Jan 2017 small “glowing” pelvic node. Scan 2017, August 2017 PSA 3.5 Mayo C-11 scan -many lymph node metastasis from pelvic to infraclavicular areas. Option to begin chemo or Xtandi. September 2017 Xtandi started. PSA continued to rise. After three months of trial he failed on Xtandi we went for a rescan at Mayo clinic. This scan showed lymph node progression. There was also questionable neuroendocrine prostate cancer disease. January 2018 PSA 14.5 and jevtana and carboplatin every 21 days. PSA begin to increase by 1 to 2 points every three weeks. Current PSA 21.8. CT scan done showing minimal progression of lymph node disease but metastasis to spine and pelvic bone. Total of four rounds of chemo done with Jevtana and carboplatin. Gardent 360 blood test and biopsy completed three weeks ago. We are now awaiting the results and stains of the biopsy. My father’s medical oncologist Based on his pathology reports and genetic mutations will decide if my father will go on with Keytruda or will qualify and get excepted to the trial use of Optiva and Cabozantinib. Anyone have any experience with these medications and prostate cancer resistant to all of the treatments thus far?

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Hi there,

Is this an immunotherapy trial? I think this is the one my dad's doc tried to enroll him in.

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Yes

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Ok. Yes. His oncologist has some good reviews from it from those in his trial. My dad has an autoimmune issue that would not make him a good candidate.

From what I was told there are a few side effects with skin rash being one of them.

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We are also Waiting for pathology report to figure it out but meanwhile I’m asking around to see if anyone has been in the trial or experienced these treatments. It’s so frightening just waiting with no treatment..

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Tell me about it. It's extremely hard waiting for approvals, test results, stopping drugs, etc.

I even find myself wanting to continue drugs that don't work, until we are on the next thing.

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That’s what we wanted to do but we had to stop chemo just in case he is able to get on the study

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Hope you get in and that it works. Can not give up , We can’t give up now.

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Ha ha ha.. what a saga... the next thing!!

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Unfortunately we were unable to get him on the trial because they stopped enrolling for prostate.

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Oh no. It filled fast here in Chicago as well. The one spot that would have been for my dad only became available because someone did not qualify and neither did my dad in his case.

On to Keytruda?

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Yes, I’m bummed!! So what is your father doing instead.

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We start Docataxel on Thursday. We're going with 60 mg, every four weeks.

I understand how you feel because I'm actually bummed about that.

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We're doing this as a requirement for a parp trial.

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We are still waiting for pathology results to see if he is MSI high. But this lull in waiting time is worrisome.

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Very much so. I have lost weight, smoking like a chimney, and lost hours of sleep.

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I don’t let me father worry- i worry about it! There’s nothing that can be done.. patience is everything. Wishing you the best, go out and enjoy the day as much as possible . Hugs to you!

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Hugs to you too. Keep your head up and many prayers.

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Daddy’s daughter, good to hear from you. I wish things had gone better. Must be disheartening and fearful. You have witnessed the treatments and the side effects of APC. It’s a cruel beast when it’s running amuck in us. I pray for your dad to get a break in the storm . God bless your Father and daddy’s daughter too. Keep yourself strong. Peace in your heart..

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Thank you 😊

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My experience with Keytruda is for my Lung Melanoma, and it's working. On Friday I asked my oncologist if it's helping with my (or others) PCa, he said the verdict is still out on that.

Good Luck and Good Health.

j-o-h-n Tuesday 04/10/2018 7:54 AM EDT

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I know that it may or may not help. We will have to try if that’s the only option left! Thank you John!

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John,

After looking at your pic I think the Keytruda had side effects

Gus

i3.mirror.co.uk/incoming/ar...

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THANKS Gus, that's why they call me BUBBLEWRAP.

Good Luck and Good Health.

j-o-h-n Friday (the thirteenth) 04/13/2018 8:10 PM EDT

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I had to say that was a pretty awful pic!! Lol

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DD,

In Jan 2017 when Mayo scan detected 1 glowing node why didn't they go after it

Gus

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His PSA was only 1.6 and they couldn’t determine if it was infection or metastatic “glow”. But After his PSA rose to 3.5 then the C– 11 PET show metastasis to lymph nodes from pelvic region up to supraclavicular.Their first recommendation at that time was chemo or Xtandi. My father had chosen to try the Xtandi route but failed. Rescan at the end of 2017 showed more affected nodes.

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DD,

was the scan done at Mayo...usually they do a needle biopsy to determine if the node is PCa

Gus

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They didn’t offer at that time

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Where is the trial

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City of hope

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Is there somewhere in USA where they do the gene testing ? It is not common here in South Africa and I know of someone who was tested in Belgium ?

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